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Mammalian Monoclonal DLG4 Primary Antibody pour ISt, IHC - ABIN1304919
Higuchi, Macke, Lee, Miller, Xu, Ikeda, Ikeda: Genetic basis of age-dependent synaptic abnormalities in the retina. dans Mammalian genome : official journal of the International Mammalian Genome Society 2015
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Human Monoclonal DLG4 Primary Antibody pour BP, ChIP - ABIN4348100
Fogel, Akins, Krupp, Stagi, Stein, Biederer: SynCAMs organize synapses through heterophilic adhesion. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
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Human Polyclonal DLG4 Primary Antibody pour IP, WB - ABIN1742271
Li, Hu, Höfer, Wong, Cooper, Birnbaum, Hammer, Hofmann: DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory. dans The Journal of biological chemistry 2010
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Human Polyclonal DLG4 Primary Antibody pour IF (p), IHC (p) - ABIN725930
Zhao, Li, Wei, Savage, Zhou, Ma: Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring. dans Neurobiology of disease 2014
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Human Polyclonal DLG4 Primary Antibody pour ELISA, IHC - ABIN1585109
Wessel, Balakrishnan-Renuka, Henkel, Meyer, Meller, Brand-Saberi, Theiss: Long-term incubation with mifepristone (MLTI) increases the spine density in developing Purkinje cells: new insights into progesterone receptor mechanisms. dans Cellular and molecular life sciences : CMLS 2014
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Mouse (Murine) Polyclonal DLG4 Primary Antibody pour WB - ABIN152631
Reissner, Boyle, Ye, Carew: Aplysia synapse associated protein (APSAP): identification, characterization, and selective interactions with Shaker-type potassium channels. dans Journal of neurochemistry 2008
Mammalian Monoclonal DLG4 Primary Antibody pour ISt, IHC - ABIN1304920
Gonzalez-Lozano, Klemmer, Gebuis, Hassan, van Nierop, van Kesteren, Smit, Li: Dynamics of the mouse brain cortical synaptic proteome during postnatal brain development. dans Scientific reports 2016
Human Polyclonal DLG4 Primary Antibody pour IHC, IHC (p) - ABIN4348101
Fourie, Kim, Waldvogel, Wong, McGregor, Faull, Montgomery: Differential Changes in Postsynaptic Density Proteins in Postmortem Huntington's Disease and Parkinson's Disease Human Brains. dans Journal of neurodegenerative diseases 2015
The authors find that the tumor suppressor Discs large (Dlg) links the Par (Montrer AFG3L2 Anticorps) complex component atypical Protein Kinase C (Montrer PRKCZ Anticorps) (aPKC) to the essential spindle orientation factor GukHolder (GukH).
The structure of dlg1 reveals that the core of the dimer is formed by a distinctive six-helix assembly, involving all three conserved helices from each subunit (monomer). The homodimer interface is extended by the C-terminal tail of the L27 (Montrer RPL27A Anticorps) domain of Dlg1, which forms a two-stranded antiparallel beta-sheet. The structure reconciles and provides a structural context for a large body of available mutational data.
Strikingly the absence of any of DLG proteins at the presynaptic terminal disrupts the clustering and localization of the calcium channel DmCa1A subunit (Cacophony), decreases the action potential-evoked release probability and alters short-term plasticity.
Exon junction complex (EJC) activity is indispensable for Wg signaling by maintaining an appropriate level of Dsh (Montrer DVL2 Anticorps) protein for Wg ligand reception in Drosophila. Genetic and biochemical experiments demonstrate that Dlg1 protein acts independently from its role in cell polarity to protect Dsh (Montrer DVL2 Anticorps) protein from lysosomal degradation.
Banderuola (Bnd) is a novel regulator of asymmetric cell division (ACD (Montrer ACD Anticorps)). The data place Bnd at the top of the hierarchy of the factors involved in ACD (Montrer ACD Anticorps), suggesting that its main function is mediating localization and function of Dlg tumor suppressor.
The inactivation of cellular cortex polarization is the most likely target of dlg inactivation in mitosis.
Loss of scrib (Montrer SCRIB Anticorps), dlg and lgl had no effect on gonad formation, but Dlg and Scrib (Montrer SCRIB Anticorps) in the gonadal mesoderm acted critically in the somatic wrapping of the pole cells and the internal structure of the Drosophila embryonic gonads.
Gliotactin and Discs large are co-regulated to maintain epithelial integrity.
Hts (Montrer APCDD1 Anticorps) regulates Dlg targeting to the neuromuscular junction in muscle and the lateral membrane of epithelial cells.
Electron microscopy reveals that during metamorphosis the subsynaptic reticulum vacuolizes in the early stages of synapse dismantling, concomitant with diffuse localization of Dlg.
PSD95 was essential for Arc (Montrer NOL3 Anticorps) assembly into 1.5-MDa complexes and activity-dependent recruitment to excitatory synapses.
Results show the binding of PSD95 to GluN subunit 2A is modulated by CIN (Montrer PDXP Anticorps).
these data identify PSD95 nanoclusters as a basic structural unit, or building block, of excitatory synapses and their number characterizes synapse size and structural diversity
This study demonstrated that in Chronic social defeat stress leads to changes PSD-95 in hippocampus of young mice.
The authors present evidence that synGAP (Montrer SYNGAP1 Anticorps)-alpha1 regulates the composition of the postsynaptic density by restricting binding to the PDZ (Montrer INADL Anticorps) domains of PSD-95.
In Fmr1 (Montrer FMR1 Anticorps) KO neurons, Mdm2 (Montrer MDM2 Anticorps) is hyperphosphorylated, nuclear localized basally, and unaffected by MEF2 (Montrer MEF2C Anticorps) activation, which our data suggest due to an enhanced interaction with Eukaryotic Elongation Factor (Montrer TSFM Anticorps) 1alpha (EF1alpha), whose protein levels are elevated in Fmr1 (Montrer FMR1 Anticorps) KO. Expression of a dephosphomimetic of Mdm2 (Montrer MDM2 Anticorps) rescues PSD-95 ubiquitination, degradation and synapse elimination in Fmr1 (Montrer FMR1 Anticorps) KO neurons.
tested the effect of five targeted mouse mutations on the assembly of known PSD95 interactors, Kir2.3 (Montrer KCNJ4 Anticorps), Arc (Montrer NOL3 Anticorps), IQsec2/BRAG1 (Montrer IQSEC2 Anticorps) and Adam22 (Montrer ADAM22 Anticorps)
Therefore, our study suggests that CREB and PSD95 are novel substrates of PERK, so inhibition of PERK phosphorylation using GSK2656157 would be beneficial against memory impairment after TBI.
PSD95 and SYP (Montrer PTPN11 Anticorps) may originate from the different sites, but they are closely related to the formation and maturation of synapse.
Expression levels of brain derived neurotrophic factor, postsynaptic density 95, and p-cyclic-AMP response element binding protein levels were significantly elevated in the testosterone (T) group, but flutamide reduced the T-induced effects in these biomarkers to control levels.
DNA methylation (Montrer HELLS Anticorps) of DLG4 and of human hippocampus and prefrontal cortex in major depression is unchanged in comparison to healthy individuals.
results suggest that rare missense mutations in the candidate PSD (Montrer PSD Anticorps) genes may increase susceptibility to SZ and/or ASD (Montrer ARSD Anticorps). These findings may strengthen the theory that rare, non-synonymous variants confer substantial genetic risks for these disorders
in postsynaptic densities, PSD95 palmitoylation, conformation, and its interactions are dynamic when associated with AMPARs and more stable when associated with NMDARs
a dual role for PSD-95 in stabilizing synaptic NMDARs by binding directly to GluN2B (Montrer GRIN2B Anticorps) but also by promoting synaptic exclusion and degradation of the negative regulator STEP61.
the authors integrate molecular and imaging data from animal models and preterm infants, and find that microglial expression of DLG4 plays a role.
Phosphorylation at Y397 induced a significant increase in affinity for stargazing. The strategy presented here to generate site-specifically phosphorylated PDZ (Montrer INADL Anticorps) domains provides a detailed understanding of the role of phosphorylation in the regulation of PSD95 interactions.
This study demonstrated that a significant decrease in the protein level of PSD-95 in major depression disorder.
These results indicate that PKC (Montrer PRRT2 Anticorps) promotes synaptogenesis by activating PSD-95 phosphorylation directly through JNK1 (Montrer MAPK8 Anticorps) and calcium/calmodulin-dependent kinase (Montrer CAMK2 Anticorps) II and also by inducing expression of PSD-95 and synaptophysin (Montrer SYP Anticorps).
The differences in cortical NMDAR (Montrer GRIN1 Anticorps) expression and post-synaptic density protein 95 are present in psychiatric disorders and suicide completion and may contribute to different responses to ketamine.
Mutation C>T at the rs13331 in the PSD95 gene is strikingly associated with an increased risk of autism spectrum disorders.
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
, disc large
, discs large
, disk large
, lethal(1)benign wing imaginal disc neoplasm
, lethal(1)discs large
, lethal(2)discs large
, discs, large homolog 4
, postsynaptic density protein 95
, disks large homolog 4
, PSD-95 alpha 2b
, PSD-95 beta
, discs large homolog 4
, synapse-associated protein 90
, synapse-associated protein SAP90
, Tax interaction protein 15
, post-synaptic density protein 95