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mitochondrial targeting of FPS may be widespread among eukaryotes
Farnesyl diphosphate synthase (FPPS) of the dipteran Drosophila melanogaster has been cloned and its catalytic properties have been assessed.
Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase
These results are consistent with the previously proposed hypothesis that the allosteric pocket of human FPPS, located near the active site, plays a feed-back regulatory role for this enzyme.
our study indicated that DR patients have higher VEGF levels than diabetic patients without retinopathy, and -2578A/C (rs699947) and +405C/G (rs2010963) may be important factors in determining serum VEGF levels.
Results suggest that polymorphisms of the FDPS gene may influence the bone response to drugs targeting the mevalonate pathway, like statins.
A co-crystal structure of human farnesyl pyrophosphate synthase in complex with a bisphosphonate and two molecules of inorganic phosphate.
The results identify new classes of FPPS inhibitors, diterpenoids and sesquiterpenoids, that bind to the IPP (Montrer IPP Kits ELISA) site and may be of interest as anticancer and antiinfective drug leads.
These observations suggest that an increase in the expression of endogenous FPPS could confer at least partial resistance to the pharmacological effect of N-BP drugs such as ZOL in vivo
LRP5 (Montrer LRP5 Kits ELISA) and FDPS loci age-specifically affect skeletal traits in healthy fertile women.
Data indicate compounds represent a new structural class of farnesyl pyrophosphate synthase (hFPPS) inhibitors and suggest a development of therapeutics.
The iPA-driven modulation of FDPS can cause an enhancement of post-translational prenylation essential for the biological activity of key proteins in NK signaling and effector functions, such as Ras.
Farnesyl pyrophosphate synthase (FPPS) may function as a potent regulator in myocardial remodelling. The FPPS-regulated signalling pathway is relevant to the pathological changes in cardiac hypertrophy and heart failure.
identified a single putative direct repeat 4 (DR4) LXR (Montrer NR1H3 Kits ELISA) response element in the FPS (Montrer FES Kits ELISA) promoter isolated from immortalized murine astrocyte P11 (Montrer S100A10 Kits ELISA)-5 cells
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
farnesyl pyrophosphate synthase
, farnesyl diphosphate synthase
, farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
, farnesyl pyrophosphate synthetase
, Farnesyl pyrophosphate synthetase
, (2E,6E)-farnesyl diphosphate synthase
, FPP synthase
, FPP synthetase
, farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase
, CR 39
, cholesterol-regulated 39 kDa protein
, farnesyl diphosphate synthetase
, testis-specific farnesyl pyrophosphate synthetase
, 6E)-farnesyl diphosphate synthase
, geranylgeranyl-diphosphate synthase