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anti-Human HEY2 Anticorps:
anti-Mouse (Murine) HEY2 Anticorps:
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Zebrafish (Danio rerio) Polyclonal HEY2 Primary Antibody pour WB - ABIN1881411
Winkler, Elmasri, Klamt, Volff, Gessler: Characterization of hey bHLH genes in teleost fish. dans Development genes and evolution 2003
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Cow (Bovine) Polyclonal HEY2 Primary Antibody pour ELISA - ABIN4317227
Tang, Urs, Liaw: Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site. dans Circulation research 2008
The findings identify HEY2 as a novel component of the NKX2-5 (Montrer NKX2-5 Anticorps) cardiac transcriptional network.
HEY2 as a promising biomarker for unfavorable outcomes and a novel therapeutic target for the clinical management of HCC (Montrer FAM126A Anticorps)
Genetic variation of HEY2 is associated with Brugada syndrome through alteration of ion channel expression in the cardiac ventricular wall.
Individuals with HEY2 duplications should be screened for congenital heart defects.
HEY2 CC genotype may be a favorable prognostic marker for BrS, protectively acting to prevent ventricular fibrillation presumably by regulating the repolarization current.
Overexpression of HEY1 (Montrer HEY1 Anticorps) and HEY2 in esophageal squamous cell carcinoma (ESCC) is correlated to different indices of poor prognosis, and it is extrapolated that such overexpression is important in progression and development of ESCC tumorigenesis.
bone morphogenic proteins within the serum of cell culture medium are potent inducers of endothelial Hey1 (Montrer HEY1 Anticorps) and Hey2 gene expression within the first few hours after medium change
a new HRD1 (Montrer SYVN1 Anticorps)-associated membrane protein named HERP2 (Montrer HEY1 Anticorps), which is homologous to the previously identified HRD1 (Montrer SYVN1 Anticorps) partner HERP1. Despite sequence homology, HERP2 (Montrer HEY1 Anticorps) is constitutively expressed in cells, whereas HERP1 is highly induced by ER stress.
Data indicate that culture abrogated differential gene expression in part due to gradual loss of canonical Notch (Montrer NOTCH1 Anticorps) activity and HEY2 expression.
Common variants at SCN5A (Montrer SCN5A Anticorps)-SCN10A (Montrer SCN10A Anticorps) and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death
Data implied that Hey2 function is restricted to transient amplifying cells of the ameloblast cell lineage and that Hey1 (Montrer HEY1 Anticorps) plays a role in the composition of the subodontoblastic layer, in addition to ameloblast differentiation.
Hey proteins mechanistically repress target genes via histone deacetylase (Montrer HDAC1 Anticorps) recruitment and histone deacetylation.
Results suggest that bone morphogenetic protein signaling plays pivotal roles in retinal progenitor cell differentiation into late differentiating retinal cell types and in Muller glia maturation; these effects were mediated, at least in part, by Hey2
Hey1 (Montrer HEY1 Anticorps) and Hey2 in endothelial cells play important roles in vascular development.
findings indicate that Hey1 (Montrer HEY1 Anticorps) and Hey2 control the spatial and temporal pattern of auditory HC differentiation.
CHF1/Hey2 may contribute to Brugada syndrome.
Common variants at SCN5A (Montrer SCN5A Anticorps)-SCN10A (Montrer SCN10A Anticorps) and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.
Data indicate that Hairy and Enhancer of Split-related with YRPW motif (HEY)2 decreases skeletal mass and regulates bone remodeling in male mice.
Data indicate that Notch1 (Montrer NOTCH1 Anticorps) and Notch2 (Montrer NOTCH2 Anticorps) are expressed and localized in the nuclei of the label-retaining cells (LRCs), and the expression of Notch (Montrer NOTCH1 Anticorps)-inducible genes, Hes1 (Montrer HES1 Anticorps) and Hey2, was elevated in LRCs.
Survivor mice lacking the Hesr2 gene exhibit fibrosis in the aortic valve and ventricle in adulthood, thus suggesting that Hesr2 plays an important role in maintaining the homeostasis of the aortic valve and ventricle.
essential role for Hey2 upstream of Notch in hematopoietic stem cell formation
Forms a complex with Gata5 through the carboxyl region and can repress Gata5-mediated transcription.
The snrk (Montrer SNRK Anticorps)-1 gene acts downstream or parallel to notch (Montrer NOTCH1 Anticorps) and upstream of gridlock during artery-vein specification
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.
hairy/enhancer-of-split related with YRPW motif protein 2
, HES-related repressor protein 1
, HES-related repressor protein 2
, cardiovascular basic helix-loop-helix factor 1
, cardiovascular helix-loop-helix factor 1
, class B basic helix-loop-helix protein 32
, hairy and enhancer of split-related protein 2
, hairy-related transcription factor 2
, protein gridlock homolog
, Hairy-E(spl)-related with YRPW motif 2
, hairy and enhancer of split related 2
, protein gridlock