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Human Monoclonal ILK Primary Antibody pour FACS, IHC - ABIN1098122
Taylor, Qiao, Colon, Schlegel, Josifi, Chung: Integrin-linked kinase regulates phosphatase and tensin homologue activity to promote tumorigenesis in neuroblastoma cells. dans Surgery 2011
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Human Polyclonal ILK Primary Antibody pour DB - ABIN389872
Ma, Chen, Ma, Lai, Yang, Yeh, Hsueh, Chu, Lai, Chen: Preservation of human limbal epithelial progenitor cells on carbodiimide cross-linked amniotic membrane via integrin-linked kinase-mediated Wnt activation. dans Acta biomaterialia 2016
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Human Polyclonal ILK Primary Antibody pour IHC (p), WB - ABIN391993
Troussard, Mawji, Ong, Mui, St -Arnaud, Dedhar: Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. dans The Journal of biological chemistry 2003
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Human Polyclonal ILK Primary Antibody pour DB - ABIN650820
Srikanth, Das, Berns, Kim, Stupp, Kessler: Nanofiber-mediated inhibition of focal adhesion kinase sensitizes glioma stemlike cells to epidermal growth factor receptor inhibition. dans Neuro-oncology 2013
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Human Polyclonal ILK Primary Antibody pour ICC, IF - ABIN253069
Dejaeger, Böhm, Dirckx, Devriese, Nefyodova, Cardoen, St-Arnaud, Tournoy, Luyten, Maes: Integrin-Linked Kinase Regulates Bone Formation by Controlling Cytoskeletal Organization and Modulating BMP and Wnt Signaling in Osteoprogenitors. dans Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2017
Human Polyclonal ILK Primary Antibody pour ELISA, IHC - ABIN257019
Hannigan, Leung-Hagesteijn, Fitz-Gibbon, Coppolino, Radeva, Filmus, Bell, Dedhar: Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. dans Nature 1996
Human Polyclonal ILK Primary Antibody pour IHC (p), WB - ABIN391996
Marotta, Parhar, Owen, Dedhar, Salh: Characterisation of integrin-linked kinase signalling in sporadic human colon cancer. dans British journal of cancer 2003
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Human Polyclonal ILK Primary Antibody pour IHC, WB - ABIN223143
Hu, Sun, Xie, Huang, Jia, Yao, Ge: Rosuvastatin changes cytokine expressions in ischemic territory and preserves heart function after acute myocardial infarction in rats. dans Journal of cardiovascular pharmacology and therapeutics 2013
Targeted knockdown of the integrin focal adhesion complex components beta-integrin, PINCH (Montrer LIMS1 Anticorps), and integrin-linked kinase caused formation of multinucleate epidermal cells within the Drosophila larval epidermis.
PINCH (Montrer LIMS1 Anticorps) and ILK have an independent capacity to localize at muscle attachment sites in vivo.
ILK functions as an essential hub in the assembly of its partner proteins at sites of integrin adhesion.
Depletion of integrin-linked kinase (ILK) in the pancreatic epithelial cells results in glucose intolerance due to a loss of the intra-islet vasculature. In turn, blood vessels accumulate at the islet periphery.
these data demonstrate the importance of integrin-mediated cell-matrix interactions and ILK signaling in osteoprogenitors in the control of osteoblast functioning during juvenile bone mass acquisition and adult bone remodeling and homeostasis.
We conclude that ILK is critical for maintaining the collecting duct epithelium and renal function and is a key intermediate for periostin (Montrer POSTN Anticorps) activation of signaling pathways involved in cyst growth and fibrosis in PKD (Montrer PRKD1 Anticorps).
Ilk and ELMO2 (Montrer ELMO2 Anticorps) modulate recycling endosomes in keratinocytes undergoing intercellular adhesion mediated through cell-cell contacts, including E-cadherin (Montrer CDH1 Anticorps)-based adherens junctions.
Ilk regulates cellular mechanics facilitating the motility in 3D extracellular matrices.
It was concluded that ILK depletion modifies the transcription of GLUT4 (Montrer SLC2A4 Anticorps), which results in reduced peripheral insulin (Montrer INS Anticorps) sensitivity and glucose uptake, suggesting ILK as a molecular target and a prognostic biomarker of insulin (Montrer INS Anticorps) resistance.
results demonstrate that TGF-beta1 (Montrer TGFB1 Anticorps)-induced autophagy links beta-catenin (Montrer CTNNB1 Anticorps) and Smad (Montrer SMAD1 Anticorps) signaling to promote epithelial-mesenchymal transition in C1.1 cells through a novel pY654-beta-catenin (Montrer CTNNB1 Anticorps)/p-Smad2 (Montrer SMAD2 Anticorps)/ILK pathway.
ILK deletion impaired the developmental profile, proliferation, and differentiation of oligodendrocyte precursor cells.
Our results define ILK as a key mechanotransducer in modulating breast cancer stem-like cells development in response to tissue mechanics and oxygen tension.
iNOS (Montrer NOS2 Anticorps)-derived NO plays a crucial role during atherosclerosis by regulating the endocytic-lysosomal degradation of ILK in endothelial cells.
Heart failure in recessive embryonic lethal zebrafish mutant main squeeze (msq) mutants is due to a mutation in the integrin-linked kinase (ilk) gene.
The lost-contact mutant on chromosome 10 encodes a nonsense mutation (Y319X) associated with defective cardiomyocytes & endothelial cells that leads to severe myocardial dysfunction. There is epistatic regulation between laminin-alpha4, integrin, & Ilk.
Data show that integrin-linked kinase is an essential component downstream of laminin and integrin alpha7, providing strengthening of skeletal muscle fibre adhesion with the extracellular matrix.
High ILK expression is associated with Neuroblastoma (Montrer ARHGEF16 Anticorps).
We further performed molecular dynamics simulation for 100ns to see the effect of urea on structural stability of kinase domain of ILK at atomic level. Structural changes with increasing concentrations of urea were analysed, and we observed a significant increase in the root mean square deviation, root mean square fluctuations, solvent accessible surface area and radius of gyration
ILK overexpression in human CRC associates with EMT and CSC traits, contributing to tumor progression and chemoresistance.
Dermal fibroblast-to-myofibroblast transition sustained by alphavss3 integrin-ILK-Snail1/Slug signaling is a common feature for hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders.
These results indicated that ILK promoted cell proliferation and growth in breast cancer cells through activation of the PI3K (Montrer PIK3CA Anticorps)/Akt (Montrer AKT1 Anticorps) pathway.
ILK-induced epithelial-mesenchymal transition is a novel mechanism in the pathogenesis of adenomyosis
Herein, we propose a new ILK-MMP9 (Montrer MMP9 Anticorps)-MRTF axis that appears to be critical for endothelial-mesenchymal transition differentiation of endothelial to cancer-associated fibroblasts -like cells. Thus, it might be an attractive target for cancer treatment
The current data support MT1-MMP (Montrer MMP14 Anticorps) as an additional ILK substrate and show that modulation of ILK expression and activity inhibit MT1-MMP (Montrer MMP14 Anticorps)-related pro-metastatic behaviors of ovarian cancer cells.
Results show that ILK is overexpressed in metastasis of bladder cancer and the up-regulation of ILK could increase cell proliferation, change cell morphology and regulate cell cycle promoting epithelial-mesenchymal transition.
This study is the first to identify EMILIN-1 (Montrer EMILIN1 Anticorps) and ILK as prospective markers of islet regenerative function in human mesenchymal stem cells.
Integrin-linked kinase (ILK, MGC129022) is an important regulator of the endothelial phenotype and vascular network formation by directing the assembly and/or maturation of alpha5beta1-competent matrix-forming adhesions.
Rac1 (Montrer RAC1 Anticorps) only partially restores the spreading defects of integrin linked kinasse (ILK)-depleted cells, suggesting that an additional ILK-dependent signal is required for cell spreading.
Profilin (Montrer PFN1 Anticorps)-dependent dissociation of G-actin (Montrer ACTB Anticorps)-Tbeta4 complexes simultaneously liberates actin for filament assembly and facilitates Tbeta4 binding to integrin-linked kinase (ILK) in the lamellipodia.
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
, Integrin-linked kinase
, integrin linked kinase
, integrin-linked protein kinase
, integrin-linked kinase
, Integrin-linked protein kinase
, integrin binding protein kinase
, main squeeze
, beta-integrin-linked kinase
, 59 kDa serine/threonine-protein kinase
, integrin-linked kinase-2