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Human Polyclonal NACa1 Primary Antibody pour IF, WB - ABIN518179
Puigmulé, López-Hellin, Suñé, Tornavaca, Camaño, Tejedor, Meseguer: Differential proteomic analysis of cyclosporine A-induced toxicity in renal proximal tubule cells. dans Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009
Data show that reduction of alpha chain (Montrer FCGRT Anticorps) of nascent polypeptide associated complex (alphaNAC) levels decreased basal expression of Low density lipoprotein receptor-Related Protein 6 (Lrp6 (Montrer LRP6 Anticorps)) by 30%.
the skNAC-Smyd1 (Montrer SMYD1 Anticorps) complex is involved in transcriptional regulation both via the control of histone methylation and histone (de)acetylation.
skNAC binds to the E3 SUMO ligase mammalian Mms21/Nse2 (Montrer NSMCE2 Anticorps) and that knockdown of Nse2 (Montrer NSMCE2 Anticorps) expression inhibits specific aspects of myogenic differentiation, accompanied by a partial blockade of the nuclear-to-cytoplasmic translocation of the skNAC-Smyd1 (Montrer SMYD1 Anticorps) complex
depletion of alphaNAC in multiple types of cancer cells induce typical apoptotic cell death. This anti-apoptotic function is mediated by the FADD/c-Jun N-terminal kinase pathway.
We propose that maximal transcriptional repression by FIAT (Montrer TXLNG Anticorps) requires its interaction with SUMOylated, HDAC2 (Montrer HDAC2 Anticorps)-interacting aNAC (Montrer NACa2 Anticorps)
Altered gene dosages for Galphas (Montrer GNAS Anticorps) and alpha- NAC in compound heterozygous mice result in reduced bone mass, increased numbers of osteocytes, and enhanced expression of Sost (Montrer SOST Anticorps).
The bone phenotype of compound Naca(+/-); Fiat (Montrer TXLNG Anticorps)(+/-) heterozygotes confirms that FIAT (Montrer TXLNG Anticorps) and alphaNAC are part of a common genetic pathway and support a role for the FIAT (Montrer TXLNG Anticorps)/alphaNAC interaction in normal bone physiology.
data suggest that skNAC controls myoblast migration and sarcomere architecture in a calpain-dependent manner
nascent polypeptide associated complex regulates specific aspects of myogenesis.
The muscle-specific (Montrer EIF3K Anticorps) transcription factor skNAC is the major binding partner for Smyd1 (Montrer SMYD1 Anticorps) in the developing heart.
Results demonstrate that skNAC plays a vital role in myofibril assembly and function during muscle cell differentiation.
Low NACA expression is associated with rhabdomyosarcoma.
[review] First evidence of a functional interaction between ATF4 (Montrer ATF4 Anticorps), FIAT (factor-inhibiting ATF4-mediated transcription (Montrer TXLNG Anticorps)) and alphaNAC (nascent polypeptide-associated complex and coactivator alpha).
NACA gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma.
identified a region in the NAC (Montrer NLRP1 Anticorps) domain of the human NAC alpha-subunit (Montrer POLG Anticorps) as a new nucleic acid-binding region, which is blocked from binding nucleic acids in the heterodimeric complex by a helix region in the beta-subunit (Montrer POLG Anticorps)
Human brain nascent polypeptide-associated complex alpha subunit is decreased in patients with Alzheimer' s disease and Down syndrome.
a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen
virtual Northern blots to analyze expression of NACA and ANX2 (Montrer ANXA2 Anticorps) in progenitor cultures of nine children with Juvenile myelomonocytic leukemia and five healthy individuals
Altogether, these results characterize NACA as a new factor involved in the positive regulation of human erythroid-cell differentiation.
Alpha NAC downregulation in hypoxic cells or NAC (Montrer NLRP1 Anticorps) ablation by NAC (Montrer NLRP1 Anticorps) short-interfering RNA (siRNA) leads to the initiation of ER stress responses, which results in caspase (Montrer CASP3 Anticorps)-dependent apoptosis.
The protein encoded by this gene associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). NAC binds to nascent proteins as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. However, nascent proteins with an exposed signal peptide will not be bound by the encoded protein, enabling them to bind the SRP and enter the secretory pathway. This protein has been determined to be an IgE autoantigen in atopic dermatitis patients. Several transcript variants encoding two different isoforms have been found for this gene.
alpha-NAC, muscle-specific form
, nascent polypeptide-associated complex alpha subunit
, nascent polypeptide-associated complex subunit alpha
, nascent polypeptide-associated complex subunit alpha, muscle-specific form
, no knack
, nascent-polypeptide-associated complex alpha polypeptide