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Prickle1 localized to the membrane through its farnesyl moiety, and the membrane localization was necessary for Prickle1 to regulate migration, to bind to CLASPs and LL5beta, and to promote microtubule targeting of focal adhesions.
upregulation of PRICKLE1 in basal breast cancers, a subtype characterized by high metastatic potential, is associated with poor metastasis-free survival.
Our experimental data demonstrate that high expression of Prickle1 and Vangl2 reduce the growth of neuroblastoma cells and indicate different roles of PCP proteins in tumorigenic cells compared to normal cells.
these findings suggest PRICKLE1 mutations contribute to ASD by disrupting the interaction with SYN1 and regulation of synaptic vesicles.
study demonstrates that PRICKLE1 could act as a predisposing factor to human neural tube defects
MINK1 interacts with and phosphorylates PRICKLE1 and PRICKLE2.
Mutations in prickle1 causes seizures.
PRICKLE1 mutations are not a frequent cause of progressive myoclous epilepsies in Southern Italy.
PRICKLE1 and PRICKLE2 mRNAs were expressed together in brain, eye and testis.
appears to serve as a nuclear receptor for REST/NRSF, REST4, and possibly other transcription factors
NRSF/REST functions as a repressor of TH transcription in NSCs via a mechanism dependent on the TH NRSE/RE1 sites.
Prickle-1 is a negative regulator of the Wnt/beta-catenin signaling pathway and is a putative tumor suppressor in human hepatocellular carcinoma
there is synergism between REST and NFkappaB in the suppression of TAC1 in non-neuronal cells
A homozygous mutation in PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome.
A physical and functional interaction between Prickle and Strabismus was found in Drosophila and Xenopus, but is likely conserved in human, too.
Prickle1 plays a role in positive regulation of differentiation and maturation of oligodendrocytes.
findings argue against the role of Prickle1 in regulating hair cell polarity in the cochlea. Instead, Prickle1 regulates the polarity-related growth of distal and central processes of apical SGNs
Prickle1 is part of a molecular mechanism that regulates facial branchiomotor neurons caudal migration.
Data suggest Prickle1 is part of the Wnt5a/PCP signaling, regulating cell polarity and affecting expression of multiple factors to stunt limb growth through altered patterns of gene expression, including the PCP genes Wnt5a and Vangl2.
Pk1 function in axonal-dendritic development associated with the maturation of CNS neurons.
Prickle1 and Prickle2 promote neurite-like process formation of C1300 cells via the Dvl1-dependent mechanism
These results suggest that RILP(also known as Prickle) expression and function control REST action more so than does REST expression and is an important regulatory role in cardiomyocyte differentiation.
both Prickle1 and Prickle2 promote neurite-like process formation of C1300 neuroblastoma cells via the Dishevelled dependent pathway
mouse Prickle1 and Prickle2 possibly regulate positive neurite formation during brain development
Results demonstrate a role for prickle1 in AB polarity formation rather than expected role as a PCP gene.
an essential component for gastrulation cell movement
Prickle regulates cell behavior during early Xenopus development; prickle and tes act together to control axial elongation.
This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3.
REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein
, REST/NRSF-interacting LIM domain protein 1
, prickle-like 1
, prickle-like protein 1
, prickle like 1
, LIM protein prickle
, prickle-like protein 1-A
, prickle homolog 1