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embryonic stem cell switching into the differentiation state can be initiated by a tissue-specific splicing regulator (Montrer PTBP2 Kits ELISA), Rbm24.
Our results show that tissue-specific expression of RBM24 can explain the neuron-specific aberrant splicing of IKBKAP (Montrer IKBKAP Kits ELISA) exon 20 in familial dysautonomia, and that ectopic expression of RBM24 in neuronal tissue could be a novel therapeutic target of the disease.
RBM24 acts at least in part through upregulating the expression of miR-25, which in turn targets MALAT1 for degradation.
Authors have identified a new function of microRNA-222 leading to alteration of myogenic differentiation at the level of alternative splicing, and provided evidence that this effect is mediated by Rbm24 protein.
Study suggests that p63 (Montrer RPE65 Kits ELISA) is regulated by RBM24 via mRNA stability, which gives an insight into understanding how posttranscriptional regulatory mechanisms contribute to p63 (Montrer RPE65 Kits ELISA) expression.
Rbm24 is a novel player in the p53 (Montrer TP53 Kits ELISA) pathway, which may be explored to restore proper cell cycle control in p53 (Montrer TP53 Kits ELISA)-deficient tumors via p21 (Montrer CDKN1A Kits ELISA).
it was found that this protein Rbm24 regulates myogenic differentiation via the p21 (Montrer CDKN1A Kits ELISA) signal pathway.
Study suggests that p63 (Montrer CKAP4 Kits ELISA) is regulated by RBM24 via mRNA stability, which gives an insight into understanding how posttranscriptional regulatory mechanisms contribute to p63 (Montrer CKAP4 Kits ELISA) expression.
RBM24 is sufficient to mediate muscle-specific (Montrer EIF3K Kits ELISA) exon inclusion.
Rbm24 plays a crucial role in myogenic differentiation at least in part through a myogenin (Montrer MYOG Kits ELISA)-dependent post-transcriptional regulatory pathway.
Seb4 is a target of MyoD (Montrer MYOD1 Kits ELISA) during myogenesis and is required for myogenic gene expression.
Both Rbm24a and Rbm24b are also required for normal somite and craniofacial development.
Rbm24 involving in the regulation of cardiac gene expression, sarcomeric assembly, and cardiac contractility.
rbm24a is a key developmental cardiac genes with unequal roles in cardiovascular formation
Plays a role in myogenic differentiation by regulating MYOG levels. Binds to the 3'-UTR of MYOG mRNA and regulates its stability (By similarity).
RNA-binding protein 24
, RNA-binding motif protein 24
, RNA-binding region (RNP1, RRM) containing 1
, RNA binding motif protein 24
, RNA-binding region (RNP1, RRM) containing 6
, RNA-binding region-containing protein 6
, RNA-binding motif protein 24-A
, RNA-binding protein 24-A
, RRM domain-containing protein SEB-4
, RRM-containing protein SEB-4
, RNA binding protein
, RNA-binding protein SEB-4