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Human DICER1 Protein expressed in HEK-293 Cells - ABIN2719477
Zhang, Li, Deng, Liu, Chen, Tang, Wang, Cao, Fang, Wen, Xu, Chen, Shi, Li, Xie, Tang: Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents. dans Nucleic acids research 2016
We tested the role of microRNAs in hepatic stellate cells by hepatic stellate cell-specific Dicer deletion. Although Dicer deletion decreased microRNA expression in hepatic stellar cells and altered the expression of select genes, it only exerted negligible effects on hepatic stellate cells activation and liver fibrosis
Dicer localisation is dynamic and not exclusively cytoplasmic, particularly in cells exposed to DNA damage.
Loss of Dicer1 expression is associated with ovarian tumor cells originating in the fallopian tube stroma.
Dicer is crucial for maintenance of adult dopaminergic neurons, whereas a stimulation of microrna production can promote neuronal survival.
Data show that Dicer1(Flox/-) mice histologically and genetically resemble human angiosarcoma.
These findings reveal that Dicer, through its production of mature miRNAs, plays a key role in the maintenance of monosynaptic sensory-motor circuits.
we found that the miRNA biogenesis enzyme DICER was required for the binding of the PRC2 core components EZH2 and SUZ12, and for the presence of the PRC2-mediated histone modification H3K27me3 at many bivalent genes
Lack of Dicer leads to oxidative stress, cytosolic acidification, upregulated NHE1 (Montrer SLC9A1 Protéines) expression and activity as well as swelling of CD4 (Montrer CD4 Protéines)+ T cells, functions all reversed by miR (Montrer MLXIP Protéines)-15b or miR (Montrer MLXIP Protéines)-200b.
Results show that elevated miR (Montrer MLXIP Protéines)-15b as an early response to Dicer depletion silenced Pim-1 (Montrer PIM1 Protéines) kinase resulting in mitochondrial dysfunction. Rescue experiments demonstrated that suppression of miRNA-15b induction in Dicer-deleted adult hearts result in marked amelioration of cardiac dysfunction.
Dicer1 ablation impairs Shh-induced granule neuron precursor proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17 approximately 92 cluster members. This study establishes a molecular link between miRNAs and cell cycle progression in the proliferating Granule neuron precursors during normal cerebellar development and may facilitate miRNA application in treating med...
Testing for DICER1 mutations may be beneficial for distinguishing between ovarian Sertoli-Leydig cell tumors subtypes and from other tumors in the ovarian sex cord-stromal tumors category, as well as other primary tumors of the ovary
DICER rs3742330 AG+GG genotype was associated with more advanced T stage compared to AA genotype ( P=0.009). More patients with XPO5 (Montrer XPO5 Protéines) rs2257082 CC genotype had poorly differentiated tumors compared with CT+TT genotype carriers..), carriers of RAN rs14035 CC genotype had higher three-year OS rate than carriers of CT+TT genotype (adjusted HR 3.174; 95% CI 1.010, 9.973; P=0.048).
DICER1 hot-spot mutation is the key-driving event in a subset of gynandroblastomas containing components of Sertoli-Leydig cell tumour and juvenile granulosa cell tumour
Data indicate that Dicer protein was specifically overexpressed in ovarian tumor stroma
Different genotypes frequency of DICER1 (rs12323635, rs1057035, rs13078 and rs3742330) were determined by sequencing method in 385 infertile men and 120 fertile controls. It was found that CC genotype (P = 0.000) and C allele (P = 0.0) of rs1057035 T > C polymorphism were associated with idiopathic male infertility (azoospermia).
DICER1-AS1 regulates the proliferation, invasion and autophagy of osteosarcoma via miR-30b/ATG5 axis.
neither likely pathogenic nor pathogenic variants in DICER1 appear to play a major role in transposition of the great arteries.
first report of DICER1 mutations in pulmonary blastoma.
Decreased argonaute 2 (Montrer EIF2C2 Protéines) and dicer1 in peripheral blood mononuclear cells from War Veterans with post-traumatic stress disorder leads to diminished miRNA resulting in elevated inflammation.
Diminished androgen action during gestation induces changes in Dicer1 mRNA expression.
The primary cDNA sequence of porcine Dicer was determined, and its expression in porcine oocytes and early stage embryos was confirmed.
Studied Dicer gene expression during early bovine embryo development.An increase in Dicer expression was detected in the mature oocytes sampled (P<0.05), implying that gene repression occurs during meiosis II.
Dynamic miRNA expression patterns during retinal regeneration in zebrafish: reduced dicer or miRNA expression suppresses proliferation of Muller glia-derived neuronal progenitor cells
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.
Dicer1, Dcr-1 homolog
, endoribonuclease Dicer
, dicer 1, ribonuclease type III
, double-stranded RNA-specific endoribonuclease type III
, double-strand-specific ribonuclease mDCR-1
, dicer 1, double-stranded RNA-specific endoribonuclease
, helicase MOI
, helicase with RNAse motif
, dsRNA-specific ribonuclease