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Human Polyclonal POLL Primary Antibody pour ELISA - ABIN547208
García-Díaz, Bebenek, Sabariegos, Domínguez, Rodríguez, Kirchhoff, García-Palomero, Picher, Juárez, Ruiz, Kunkel, Blanco: DNA polymerase lambda, a novel DNA repair enzyme in human cells. dans The Journal of biological chemistry 2002
A direct involvement of T1G10520 in the repair of the DNA double strand breaks in a plant genome.
White light positively regulates AtPollambda expression.
DNA Pol lambda recognizes 8-Oxo-G on a template as a normal guanine and preferentially incorporates dCTP over dATP opposite this lesion.
PAXX, XLF and XRCC4 synergise in the efficient DNA double-strand breaks recruitment, substrate recognition and stimulation of Pol lambda enzymatic activity during nonhomologous end joining DNA repair.
Bond formation and cleavage reactions catalyzed by base excision repair DNA polymerases beta and lambda has been described.
When mutated or deregulated, DNA polymerase lambda can also be a source of genetic instability. Its multiple roles in DNA damage tolerance and its ability in promoting tumor progression make it also a possible target for novel anticancer approaches. [review]
Data suggest that individuals who carry the rs3730477 POLL germline variant have an increased risk of estrogen-associated breast cancer.
T204 was identified as a main target for ATM/DNA-PKcs phosphorylation on human POLL, and this phosphorylation may facilitate the repair of a subset of IR-induced DSBs and the efficient POLL-mediated gap-filling during NHEJ. POLL phosphorylation might favor POLL interaction with the DNA-PK complex at DSBs.
The authors demonstrate that Pol lambda has a flexible active site that can tolerate 8-oxo-dG in either the anti- or syn-conformation. Importantly, we show that discrimination against the pro-mutagenic syn-conformation occurs at the extension step and identify the residue responsible for this selectivity.
Pol beta, to a greater extent than Pol lambda can incorporate rNMPs opposite normal bases or 8-oxo-G, and with a different fidelity. Further, the incorporation of rNMPs opposite 8-oxo-G delays repair by DNA glycosylases.
Fen1 significantly stimulated trinucleotide repeats expansion by Pol beta, but not by the related enzyme Pol lambda.
DNA polymerase lamda catalyzes lesion bypass across benzo[a]pyrene-derived DNA adducts.
pol lambda is responsible for a significant fraction of Fapy.dG-induced G --> T mutations.
Structural basis for the binding and incorporation of nucleotide analogs with L-stereochemistry by human DNA polymerase lambda.
A specific N-terminal extension of the 8 kDa domain of DNA polymerase lambda is important for the non-homologous end joining function.
Inactivation of polymerase (DNA directed) lambda lyase activity by 5'-(2-phosphoryl-1,4-dioxobutane prevents the enzyme from conducting polymerization following preincubation of the protein and DNA.
The results provides evidence that DNA pol lambda is required for cell cycle progression and is functionally connected to the S phase DNA damage response machinery in cancer cells.
A structural study shows how a ribonucleotide can be accommodated in the DNA polymerase lambda active site.
Results reveal that DNA pol lambda and DNA ligase I are sufficient to promote efficient microhomology-mediated end-joining repair of broken DNA ends in vitro.
Both Pol lambda- and (Pol kappa)-positive staining were associated with shorter survival in glioma patients.
Pollambda may play a specialized role in the process of repair of these kinds of lesions
Studies indicate that pol lambda undergoes posttranslational modifications during the cell cycle that regulate its stability and possibly its subcellular localization.
In vitro gap-directed translesion DNA synthesis of an abasic site involving human DNA polymerases epsilon, lambda, and beta.
DNA polymerases beta and lambda in single-nucleotide and multinucleotide pathways of mammalian base excision DNA repair
Pol mu and Pol lambda play a key role in conferring on NHEJ the flexibility required for accurate and efficient repair
Results show that deficiency of either DNA polymerases beta or lambda or both results in a modest but significant decrease in V region somatic hypermutation (SHM) with no effect on mutation specificity, suggesting no direct role in SHM.
both pol lambda and pol beta interact with the upstream DNA glycosylases for repair of alkylated and oxidized DNA bases
analysis of the interaction between DNA Polymerase lambda and anticancer nucleoside analogs
Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.
Pol lambda is not required for normal Ig gene hypermutation.
Pol lambda contributes to base excision repair in mouse fibroblast cell extract.
Pol lambda protects cells against oxidative stress, and participates in oxidative DNA damage base excision repair.
third hypervariable region assumes for each immunoglobulin chain, with pol lambda maintaining a large heavy chain junctional heterogeneity and pol mu ensuring a restricted light chain junctional variability
This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described.
DNA polymerase lambda
, DNA-directed DNA polymerase lambda
, polymerase (DNA directed), lambda
, DNA polymerase lambda-like
, DNA polymerase beta-2
, DNA polymerase beta-N
, DNA polymerase kappa
, pol Lambda