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anti-Human XRCC3 Anticorps:
anti-Mouse (Murine) XRCC3 Anticorps:
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Human Polyclonal XRCC3 Primary Antibody pour IP, WB - ABIN151186
Yoshihara, Ishida, Kinomura, Katsura, Tsuruga, Tashiro, Asahara, Miyagawa: XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells. dans The EMBO journal 2004
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Human Monoclonal XRCC3 Primary Antibody pour ICC, IF - ABIN151307
Forget, Bennett, Knight: Xrcc3 is recruited to DNA double strand breaks early and independent of Rad51. dans Journal of cellular biochemistry 2004
Show all 10 Pubmed References
Monoclonal XRCC3 Primary Antibody pour WB - ABIN534116
Compton, Choi, Cesare, Ozgür, Griffith: Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells. dans Cancer research 2007
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Polyclonal XRCC3 Primary Antibody pour WB - ABIN540236
Szüts, Simpson, Kabani, Yamazoe, Sale: Role for RAD18 in homologous recombination in DT40 cells. dans Molecular and cellular biology 2006
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Mouse (Murine) Polyclonal XRCC3 Primary Antibody pour IHC, WB - ABIN3023006
Dong, Wang, Wang, Zhang, Zhu, Gao, Yang, Qin, Liang, Chen, Deng, Ning, Liang, Gao, Xu: A stress-induced cellular aging model with postnatal neural stem cells. dans Cell death & disease 2014
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Human Polyclonal XRCC3 Primary Antibody pour IHC, WB - ABIN6673450
Zhang, Tang, Jiang, Mao: The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression. dans Oncogene 2017
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XRCC3 polymorphism is associated with Colorectal Cancer Risk.
There was no statistical association of XRCC3 T241M with type 2 diabetes mellitus or to diabetic nephropathy in a Turkish population.
Combined effects of RAD51 (rs1801320 and rs1801321) and XRCC3 (rs861539) SNPs with environmental carcinogens (tobacco and alcohol) are associated with oral and oropharyngeal squamous cell carcinoma development.
Women with GA and AA genotypes of DNA repair protein XRCC1+399A/G showed 2.4-3.8 fold higher risk of cervical cancer, however, DNA repair proteins XRCC2+31479G/A and XRCC3+18067C/T polymorphisms did not show any statistically significant associations.
results in a large sample of both sporadic and familial cases of breast cancer showed insignificant role of XRCC3 Thr241Met in the pathogenesis of this type of malignanc
241Met increases the risk of left ventricular hypertrophy via accumulation of DNA damage
Results showed that glioblastomas overexpress XRCC3, which might contribute to their intrinsic temozolomide (TMZ) resistance. Its knockdown sensitizes glioma cells to TMZ-induced cell death, apoptosis and inhibition of cell cycle progression which are attributed to the decreased repair of DNA double-strand breaks. These finding provide evidence that XRCC3 causes resistance of glioma cells to TMZ.
Results indicated that,the rs12432907 of XRCC3 carrying T allele, the rs144848 of BRCA2 with C allele and the rs1805800 of NBS1 with genotype(TT) of individuals were associated with lower genetic damage, while the rs2295152 of XRCC3 carrying T allele, the rs13312986 (CC and CT genotypes) and the rs2697679 of NBS1 with A allele were associated with higher genetic damage in workers exposed to chromate.
XRCC3 Thr241Met gene polymorphism in Asian population was associated with osteosarcoma risk, but XRCC3 Thr241Met CC genotype was not associated with Enneking stage, tumor location, and tumor metastasis. [meta-analysis]
A direct role of XRCC3 in maintaining mtDNA integrity under replication stress conditions.XRCC3 binds to mtDNA control regions along with POLG.
According to the results obtained the rs1544410 AA genotype (VDR gene) and the presence of less than 20 CAG repeats in the 1st exon (AR gene) are the risk factors for the development of prostate cancer. The het- erozygous genotype 722 CT (XRCC3 gene) demonstrated the protective effect.
Low XRCC3 rs861539 T allele is associated with breast Cancer.
Although XRCC3 plays a role in asthma etiology, the variant XRCC3 genotypes do not serve as practicable predictive markers for asthma risk in Taiwanese.
Our present case-control study has shown that tryptophan allele (R/W-W/W genotype) in XRCC1A (Arg194Trp) gene significantly increased the risk of breast cancer 1.44-fold..the present case-control study did not reveal any significant association of XRCC3 (Thr241Met) polymorphism with the risk of breast cancer in females from NE region of India
Our results indicated a link between ERCC1 rs3212986 and the onset of late gastrointestinal toxicity ..No association was found regarding the XRCC3 rs861539 polymorphism and any clinical toxicity event
XRCC3 gene SNPs could influence the tumour aggressiveness expressed by tumour grade in hepatocellular carcinoma.
XRCC3 deleterious variants were identified in breast and ovarian cancer cases.
DNA sequencing was performed for six single-nucleotide polymorphisms in the GSTP1, RAD51, XRCC1 and XRCC3 genes in BC patients and the control group. Two variants in the 5'-UTR of the XRCC3 and RAD51 genes showed a significant association with susceptibility to breast cancer. Additionally, authors reported 2 mutations in intron 7 of the XRCC3 gene.
results indicate XRCC3 Thr241Met and TYMS 5'-UTR VNTR polymorphisms are associated with time-to-metastasis, and may have potential biological roles in expediting the metastatic process
hypermethylation of homologous recombination DNA repair genes including RAD51B and XRCC3 is associated with an inflamed phenotype in squamous cell cancers of the head and neck, lung and cervix.
the RAD51C-XRCC3-associated Holliday junction resolvase complex associates with crossovers and may play an essential role in the resolution of recombination intermediates prior to chromosome segregation
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.
DNA repair protein XRCC3
, X-ray repair cross-complementing protein 3
, X-ray repair complementing defective repair in Chinese hamster cells 3
, DNA-repair protein XRCC3