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Our data have shown for the first time the regulation of CacyBP/SIP gene expression by NFAT1 (Montrer NFAT1 Anticorps). Since NFAT (Montrer NFATC1 Anticorps) transcription factors are involved in processes related to immune response, these results indicate potential involvement of CacyBP/SIP in the immune system.
These results suggest that CacyBP/SIP may be promoting growth of colon cancer cells by enhancing ubiquitin-mediated degradation of p27kip1 (Montrer CDKN1B Anticorps).
The biological characteristics a (Montrer SIAH1 Anticorps)nd target proteins of CacyBP/SIP and its exact role in various cancers are discussed. Re (Montrer S100A6 Anticorps)view.
CacyBP/SIP nuclear translocation contributes to the proliferation of gastric cancer cells, and CacyBP/SIP exerts this effect, at least in part, by stimulating ubiquitin-mediated degradation of p27Kip1 (Montrer CDKN1B Anticorps).
CacyBP/SIP plays an important role in inhibiting apoptosis of glioma cells which might be mediated by ERK1/2 signaling pathway.
CacyBP/SIP is a useful indicator of dis processes in Chronic Lymphocytic Leukemia (CLL) and plays an important role in sustaining the balance of cell proliferation and apoptosis.
CacyBP/SIP nuclear translocation promotes the proliferation and cell cycle progression of gastric cancer cells.
Overexpression of CacyBP is associated with glioma.
This study presents CacyBP as a promising candidate biomarker for colorectal cancer (CRC (Montrer CALR Anticorps)) metastasis and also sheds light on the underlying molecular mechanism by which CacyBP promotes CRC (Montrer CALR Anticorps) metastasis.
CacyBP enhances multidrug resistance of pancreatic cancer cells by regulation of P-gp (Montrer ABCB4 Anticorps) and Bcl-2 (Montrer BCL2 Anticorps).
involvement of CacyBP/SIP in the regulation of p38 (Montrer CRK Anticorps) kinase activity, in addition to that of ERK1/2, might point to the function of CacyBP/SIP in pro-survival and pro-apoptotic pathways.
In undifferentiated and differentiated tumor cells, CacyBP level has an effect on the ERK1/2-CREB (Montrer CREB1 Anticorps)-BDNF (Montrer BDNF Anticorps) pathway.
Calcyclin-binding protein/Siah-1 (Montrer SIAH1 Anticorps)-interacting protein (CacyBP/SIP) was initially described as a binding partner of S100A6 (Montrer S100A6 Anticorps) in the Ehrlich ascites tumor cells and later as a Siah-1 (Montrer SIAH1 Anticorps)-interacting protein. Its role has been studied in various mouse tumors and cell lines. Review.
sumoylated CacyBP/SIP is present in the cytoplasmic and not in the nuclear fraction. We have also established that lysine 16 is the residue which undergoes sumoylation in the CacyBP/SIP protein.
different activity of CacyBP/SIP in neuroblastoma (Montrer ARHGEF16 Anticorps) NB2a and colon cancer HCT116 cells might affect the ERK1/2 pathway in the differentiation or proliferation processes
new insight into the interaction between S100 proteins and CacyBP/SIP
SIP (-/-) embryonic fibroblasts have increased levels of cytosolic p27 (Montrer CDKN1B Anticorps) and exhibit increased cell motility compared to wild-type cells.
CacyBP/SIP exhibits a phosphatase activity toward ERK1/2 kinases while its E217K (Montrer Ube2g1 Anticorps) mutant does not.
Cacybp is associated with acute lung injury
Data indicated that CacyBP/SIP could simultaneously interact with tubulin (Montrer TUBB Anticorps) and actin, suggesting that CacyBP/SIP might link actin and tubulin (Montrer TUBB Anticorps) cytoskeletons.
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, calcyclin binding protein
, Calcyclin binding protein
, S100A6-binding protein
, Siah-interacting protein (SIP)
, growth-inhibiting gene 5 protein
, siah-interacting protein