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anti-Human HMGCS2 Anticorps:
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Cow (Bovine) Polyclonal HMGCS2 Primary Antibody pour WB - ABIN2776880
Bouchard, Robert, Vinarov, Stanley, Thompson, Morris, Leonard, Quant, Hsu, Boneh, Boukaftane, Ashmarina, Wang, Miziorko, Mitchell: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: clinical course and description of causal mutations in two patients. dans Pediatric research 2001
Show all 3 Pubmed References
miR (Montrer MLXIP Anticorps)-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma
this studies demonstrate that HMGCS2 functions as a transcriptional factor that binds to peroxisome proliferator-activated receptor alpha (PPARalpha (Montrer PPARA Anticorps)), resulting in Src (Montrer SRC Anticorps) expression and activation in a metabolically independent manner
HMGCS2 shares with ketone bodies common features in autophagic clearance of APP (Montrer APP Anticorps), suggesting that ketone bodies play an important role in HMGCS2 regulation of the autophagy.
High expression of either HSD17B2 (Montrer HSD17B2 Anticorps) or HMGCS2 predicted poor susceptibility of rectal cancer to preoperative chemoradiotherapy.
FABP7 (Montrer FABP7 Anticorps) and HMGCS2 may have roles in apocrine differentiation categorizing apocrine carcinoma of the breast
In Fe-S cluster-deficient muscles, results show a dramatic up-regulation of the ketogenic enzyme HMGCS2 and the secreted protein FGF21 (fibroblast growth factor 21 (Montrer FGF21 Anticorps)).
An alternative transcript of HMGCS2 carrying a deletion of exon 4, and two alternative transcripts of HMGCL (Montrer HMGCL Anticorps) with deletions of exons 5 and 6, and exons 5, 6 and 7, respectively, were detected.
Human HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 (Montrer FGF21 Anticorps) expression
Ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc (Montrer MYC Anticorps)-mediated repression of the key metabolic gene HMGCS2.
It is a key enzyme for catalyzing b-hydroxybutyric acid production, and observed in early Alzheimer's disease.And a hepatic inflammatory factor, IL-6 (Montrer IL6 Anticorps) enhances ketogenesis through HMGCS2 signaling activation by p38 (Montrer CRK Anticorps)/NF-kB p65.
Using in vitro ketosis model by glucose starvation, studied inhibition of ketosis by momilactone B. Found momilactone B could regulate the angiopoietin-like-3 (ANGPTL3 (Montrer ANGPTL3 Anticorps))-lipoprotein lipase (LPL (Montrer LPL Anticorps))pathway, and suppressed the expression of HMGCS2 through the increased expression of STAT5b (Montrer STAT5B Anticorps).
HMGCS2 was identified as a major down-regulated protein in colonic crypts isolated from Keratin 8 (Montrer KRT8 Anticorps)-/- mice.
The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
, HMG-CoA synthase
, hydroxymethylglutaryl-CoA synthase, mitochondrial
, 3-hydroxy-3-methylglutaryl coenzyme A synthase
, 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
, hydroxymethylglutaryl-CoA synthase 2
, hydroxymethylglutaryl-CoA synthase, mitochondrial-like
, hydroxymethylglutaryl-CoA synthase
, hydroxymethylglutaryl-coa synthase
, putative hydroxymethylglutaryl-CoA synthase family protein
, 3-HYDROXY-3-METHYLGLUTARYL-CoA SYNTHASE 2
, 3-hydroxy-3-methylglutaryl-CoA synthase 2
, 3-hydroxy-3-methylglutary-Coenzyme A synthase 2