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anti-Human CRY2 Anticorps:
anti-Mouse (Murine) CRY2 Anticorps:
anti-Rat (Rattus) CRY2 Anticorps:
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Human Polyclonal CRY2 Primary Antibody pour IHC (p), ELISA - ABIN4369822
Allikmets, Gerrard, Hutchinson, Dean: Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. dans Human molecular genetics 1997
Show all 3 Pubmed References
Cow (Bovine) Polyclonal CRY2 Primary Antibody pour IHC, WB - ABIN2784909
Currie, Doherty, Sillar: Deep-brain photoreception links luminance detection to motor output in Xenopus frog tadpoles. dans Proceedings of the National Academy of Sciences of the United States of America 2016
Human Polyclonal CRY2 Primary Antibody pour IHC (p), WB - ABIN390080
Ozgur, Sancar: Purification and properties of human blue-light photoreceptor cryptochrome 2. dans Biochemistry 2003
Show all 6 Pubmed References
Molecular basis for blue light-dependent phosphorylation of Arabidopsis CRY2 has been described.
The results demonstrate a CRY-BIC negative-feedback circuitry that regulates the activity of each other.
Verticillium dahliae PevD1 indirectly activates Arabidopsis CRY2 by antagonizing NRP (Montrer NRP1 Anticorps) functions. The promotion of CRY2-mediated flowering by a fungal effector outlines a novel pathway by which an external stimulus is recognized and transferred in changing a developmental program.
CRY2-CIB1 (Montrer CIB1 Anticorps) and CRY2-CRY2 interactions are governed by well-separated protein interfaces at the two termini of CRY2.
Exposure to blue light is required for an in vivo-association of CRY1 (Montrer CRY1 Anticorps) and CRY2 with COP1.
Data show that the effect of 3-bromo-7-nitroindazole (3B7N) treatment on gene expression in cryptochromes cry1cry2 is considerably smaller than that in the wild type, indicating that 3B7N specifically interrupts cryptochrome function in the control of seedling development in a light-dependent manner.
It describes minimal functional CRY2 and CIB1 (Montrer CIB1 Anticorps) domains maintaining light-dependent interaction and new signaling mutations affecting Arabidopsis thaliana cryptochrome 2 (AtCRY2) photocycle kinetics.
this study identified BIC1 (blue-light inhibitor of cryptochromes 1) as an inhibitor of plant cryptochromes that binds to CRY2 to suppress the blue light-dependent dimerization, photobody formation, phosphorylation, degradation, and physiological activities of CRY2.
the blue light-dependent CRY2 degradation is significantly impaired in the temperature-sensitive cul1 (Montrer CUL1 Anticorps) mutant allele (axr6 (Montrer CUL1 Anticorps)-3), especially under the non-permissive temperature.
For growth under a canopy, where blue light is diminished, CRY1 and CRY2 perceive this change and respond by directly contacting two bHLH transcription factors, PIF4 and PIF5.
CRY2 levels (ng/mL) were markedly higher in both Metabolic syndrome (MetS (Montrer ETV3 Anticorps)) groups (non-diabetic and pre-diabetic/diabetic) (all with p-value < 0.001). A reciprocal melatonin-CRY2 relationship was observed in the MetS (Montrer ETV3 Anticorps) (non-diabetic) group (p-value = 0.003).
Independent silencing of CRY1 (Montrer CRY1 Anticorps) and CRY2 genes in HAC15 cells resulted in a mild upregulation of HSD3B2 (Montrer HSD3B2 Anticorps) without affecting HSD3B1 (Montrer HSD3B1 Anticorps) expression. In conclusion, our results support the hypothesis that CRY1 (Montrer CRY1 Anticorps) and CRY2, being AngII-regulated genes, and showing a differential expression in APAs when compared with the adjacent adrenal cortex, might be involved in adrenal cell function, and in the regulation of aldosterone production
CRY2 may be an anti-oncogene (Montrer RAB1A Anticorps) in osteosarcoma.
CRY1 (Montrer CRY1 Anticorps)/2 serve as corepressors for many NRs (Montrer SPNS1 Anticorps).
data indicate an oncogenic role of miR (Montrer MLXIP Anticorps)-181d in CRC (Montrer CALR Anticorps) by promoting glycolysis, and miR (Montrer MLXIP Anticorps)-181d/CRY2/FBXL3 (Montrer FBXL3 Anticorps)/c-myc (Montrer MYC Anticorps) feedback loop might be a therapeutic target for patients with CRC (Montrer CALR Anticorps).
In the longitudinal analysis, CRY2 SNP rs61884508 was protective from worsening of problematicity of seasonal variations of mood disorder. In the cross-sectional analysis, CRY2 SNP rs72902437 showed evidence of association with problematicity of seasonal variations, as did SNP rs1554338 (in the MAPK8IP1 (Montrer MAPK8IP1 Anticorps) and downstream of CRY2).
The earlier reported association of CRY2 variants with dysthymia was confirmed and extended to major depressive disorder.
These results demonstrate that CRY2 stability controlled by FBXL3 (Montrer FBXL3 Anticorps) plays a key role in the regulation of human sleep wake behavior.
The FOXM1 (Montrer FOXM1 Anticorps) is a negative regulator of CRY2 in breast cancer via enhancing methylation in CRY2 promoter and its high expression is an independent predictor of favorable MR-free survival in ER+ breast cancer patients.
CRY2 and FBXL3 (Montrer FBXL3 Anticorps) cooperatively degrade c-MYC (Montrer MYC Anticorps) preventing the development of cancer.
Circadian clock cryptochrome proteins Cry1 (Montrer CRY1 Anticorps) and Cry2 regulate autoimmunity.
CRY1 (Montrer CRY1 Anticorps)/2 seem to repress a distinct subset of PPAR delta (Montrer PPARD Anticorps) target genes in muscle compared to the co-repressor NCOR1 (Montrer NCOR1 Anticorps). In vivo, genetic disruption of Cry1 (Montrer CRY1 Anticorps) and Cry2 enhances sprint exercise performance in mice.
In vivo knockdown of Rfk (Montrer RFK Anticorps), Riboflavin (vitamin B2) kinase essential for FAD (Montrer FANCD2 Anticorps) synthesis, altered the expression rhythms of CRY1 (Montrer CRY1 Anticorps), CRY2, and PER1 (Montrer PER1 Anticorps)
The present study identified USP7 (Montrer USP7 Anticorps) and TDP-43 (Montrer TARDBP Anticorps) as the regulators of CRY1 (Montrer CRY1 Anticorps) and CRY2, underscoring the significance of the stability control process of CRY proteins for period determination in the mammalian circadian clockwork.
Data show that cryptochrome Cry1 (Montrer CRY1 Anticorps) and Cry2 expression must be circadian and appropriately phased to support rhythms, and arginine vasopressin (AVP (Montrer AVP Anticorps)) receptor signaling is required to impose circuit-level circadian function.
Data suggest that cryptochromes (Cry1 (Montrer CRY1 Anticorps) and Cry2) mediate periodic binding of Ck2b (Montrer CSNK2B Anticorps) (casein kinase 2beta) to Bmal1 (aryl hydrocarbon receptor nuclear translocator-like (Montrer ARNTL Anticorps) protein) and thus inhibit Bmal1 (Montrer ARNTL Anticorps)-Ser90 phosphorylation by Ck2a (Montrer CSNK2A1 Anticorps) (casein kinase 2alpha).
Cry2 exerts a critical role in the control of depression-related emotional states and modulates the chronobiological gene expression profile in the mouse amygdala.
Cry1/Cry2-deficient mice had significantly lower N6- methyladenosine methylation of RNA and lost the circadian rhythm of N6-methyladenosine levels in RNA.
Data show that the intermolecular zinc finger is important for period circadian protein (PER2 (Montrer PER2 Anticorps))-cryptochrome 2 (CRY2) complex formation.
member of a family of blue-light photoreceptors\; may regulate circadian rhythm
, cryptochrome 2
, cryptochrome Cry2
, cryptochrome 2 (photolyase-like)
, growth-inhibiting protein 37