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anti-Human ALDH1A3 Anticorps:
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Human Polyclonal ALDH1A3 Primary Antibody pour ICC, IF - ABIN4279212
Dahlhoff, Fröhlich, Arnold, Müller, Leonhardt, Zouboulis, Schneider: Characterization of the sebocyte lipid droplet proteome reveals novel potential regulators of sebaceous lipogenesis. dans Experimental cell research 2015
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Human Polyclonal ALDH1A3 Primary Antibody pour IHC (p), WB - ABIN392316
Rexer, Zheng, Ong: Retinoic acid biosynthesis by normal human breast epithelium is via aldehyde dehydrogenase 6, absent in MCF-7 cells. dans Cancer research 2001
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Dog (Canine) Monoclonal ALDH1A3 Primary Antibody pour FACS, IHC - ABIN2715885
Qiu, Pu, Guo, Wei, Zhang, Zhang, Zhong, Zheng, Chen, Bu, Ye: ALDH(+)/CD44(+) cells in breast cancer are associated with worse prognosis and poor clinical outcome. dans Experimental and molecular pathology 2016
Human Polyclonal ALDH1A3 Primary Antibody pour ICC, IF - ABIN4279211
Giraddi, Shehata, Gallardo, Blasco, Simons, Stingl: Stem and progenitor cell division kinetics during postnatal mouse mammary gland development. dans Nature communications 2015
mRNA Expression of Raldh3 during zebrafish early development.
Here the authors report the first crystal structure of human ALDH1A3 complexed with NAD(+) and the product all-trans retinoic acid (REA (Montrer PHB2 Anticorps)). The tetrameric ALDH1A3 folds into a three domain-based architecture highly conserved along the ALDHs family. The structural analysis revealed two different and coupled conformations for NAD(+) and REA (Montrer PHB2 Anticorps) that the authors propose to represent two snapshots along the catalytic cycle.
Data show that retinoic acid receptor (Montrer RARA Anticorps) responder 1 (RARRES1 (Montrer RARRES1 Anticorps)) expression is subtype-dependent and regulated by DNA methylation (Montrer HELLS Anticorps) and the expression of aldehyde dehydrogenase 1A3 (ALDH1A3).
ALDH1A3 is a poor prognostic factor for patients with intrahepatic cholangiocarcinoma who underwent hepatectomy and in those with advanced intrahepatic cholangiocarcinoma receiving chemotherapy.
high transcription activities of ALDH1A2 (Montrer ALDH1A2 Anticorps), ALDH1A3 and ALDH1L1 (Montrer ALDH1L1 Anticorps) predicted worsen overall survival in gastric cancer patients
Melanoma treatment with the novel irreversible isoform-specific ALDH1 (Montrer ALDH1A1 Anticorps) inhibitor [4-dimethylamino-4-methyl-pent (Montrer PNMT Anticorps)-2-ynthioic acid-S methylester] di-methyl-ampal-thio (Montrer ACAA1 Anticorps)-ester (DIMATE) or depletion of ALDH1A1 (Montrer ALDH1A1 Anticorps) and/or ALDH1A3, promoted the accumulation of apoptogenic aldehydes leading to apoptosis and tumor growth inhibition in immunocompetent, immunosuppressed and patient-derived xenograft mouse models.
these findings ascribe a novel function for ALDH1A3 in an aggressive glioma stem cells phenotype via the up-regulation of tissue transglutaminase (Montrer TGM2 Anticorps)
our findings define a FOXD1 (Montrer FOXD1 Anticorps)-ALDH1A3 pathway in controling the clonogenic and tumorigenic potential of mesenchymal glioma stem-like cells in glioblastoma tumors
we looked up our single center primary prostate cancer post-operative follow-up data and suggested that the high level ALDH1A3 expression could predict the poor progression-free survival in a 158-patient cohort. We concluded that ALDH1A3, localized in luminal layer in prostate epithelium, is highly expressed in prostate cancer
this report brings new information for the phenotype-genotype correlation of ALDH1A3 mutations and raises important questions, especially in terms of genetic counselling given to the patients and their families
ALDH1A3 was most relevant to extracellular matrix organization and cell adhesion biological process, and the ability of tumor invasion was suppressed after ALDH1A3 knockdown in vitro.
Study in diabetic mice reports the discovery of ALDH1A3 isoform as a biomarker of dysfunctional beta cells.
This study identifies Sam68 (Montrer KHDRBS1 Anticorps) as a key regulator of neural progenitor cell self-renewal and establishes a novel link between modulation of ALDH1A3 expression and maintenance of high glycolytic metabolism in the developing cortex.
Chromatin immunoprecipitation assay using RarB (Montrer RARB Anticorps) as the immunoprecipitation target suggests retinoic acid regulation of Aldh1a3 and Foxn1 (Montrer FOXN2 Anticorps) in mice.
Data suggest that expression of Aldh1a3/Raldh3 in placenta plays role in differentiation/placentation of glycogen (Montrer GYS1 Anticorps) trophoblast cells (junctional zone cells) via production of a local source of retinoic acid.
Raldh1 (Montrer ALDH1A1 Anticorps) and Raldh3 influence enteric nervous system structure and function and heterozygosity for Raldh2 (Montrer ALDH1A2 Anticorps) causes ENS defects
ALDH1A3 and ALDH2 (Montrer ALDH2 Anticorps) expression was detectable in ALDH (Montrer ALDH3A1 Anticorps)(very-br) and ALDH (Montrer ALDH3A1 Anticorps)(br) cells, unlike ALDH (Montrer ALDH3A1 Anticorps)(dim) cells, albeit at lower levels compared with ALDH1A1 (Montrer ALDH1A1 Anticorps) and ALDH1A2 (Montrer ALDH1A1 Anticorps).
regulation of fat depots through the concerted action of Aldh1 (Montrer ALDH1A1 Anticorps) enzymes establishes retinoic acid-dependent tandem regulation of transcription factors ZFP423 (Montrer 104125 Anticorps) and PPARgamma (Montrer PPARG Anticorps) in a depot-specific manner
Kinetic characterization of RALDH3 and 4, providing their specificities for retinal isomer substrates.
Raldh2 (Montrer ALDH1A2 Anticorps) and Raldh3 are selectively expressed in cortical stroma and in the ureteric bud during kidney development.
Three retinaldehyde dehydrogenases (RALDH1 (Montrer ALDH1A1 Anticorps), RALDH2 (Montrer ALDH1A2 Anticorps) and RALDH3), show differential expression patterns throughout later mouse organogenesis
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this gene uses retinal as a substrate, either in a free or cellular retinol-binding protein form.
aldehyde dehydrogenase 1A3
, aldehyde dehydrogenase 1 family, member A3
, aldehyde dehydrogenase family 1 subfamily A3-like
, aldehyde dehydrogenase family 1 member A3
, retinaldehyde dehydrogenase family 1 subfamily A3
, aldehyde dehydrogenase family 1 member A3-like
, acetaldehyde dehydrogenase 6
, aldehyde dehydrogenase 6
, retinaldehyde dehydrogenase 3
, aldehyde dehydrogenase family 1, subfamily A3
, aldehyde dehydrogenase-6