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anti-Human ALDH1A3 Anticorps:
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Human Polyclonal ALDH1A3 Primary Antibody pour IHC (p), WB - ABIN392316
Rexer, Zheng, Ong: Retinoic acid biosynthesis by normal human breast epithelium is via aldehyde dehydrogenase 6, absent in MCF-7 cells. dans Cancer research 2001
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Human Polyclonal ALDH1A3 Primary Antibody pour ICC, IF - ABIN4279212
Dahlhoff, Fröhlich, Arnold, Müller, Leonhardt, Zouboulis, Schneider: Characterization of the sebocyte lipid droplet proteome reveals novel potential regulators of sebaceous lipogenesis. dans Experimental cell research 2015
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Dog (Canine) Monoclonal ALDH1A3 Primary Antibody pour FACS, IHC - ABIN2715885
Qiu, Pu, Guo, Wei, Zhang, Zhang, Zhong, Zheng, Chen, Bu, Ye: ALDH(+)/CD44(+) cells in breast cancer are associated with worse prognosis and poor clinical outcome. dans Experimental and molecular pathology 2016
Human Polyclonal ALDH1A3 Primary Antibody pour ICC, IF - ABIN4279211
Giraddi, Shehata, Gallardo, Blasco, Simons, Stingl: Stem and progenitor cell division kinetics during postnatal mouse mammary gland development. dans Nature communications 2015
Expressed in the developing inner ear.
mRNA Expression of Raldh3 during zebrafish early development.
ALDH1A3 is the key isoform that contributed to Aldefluor positivity in cell lines. Knocking down ALDH1A3 in different cancer cells conferred opposite phenotypes due to differential effects on CXCR4 expression. There was a significant negative correlation between ALDH1A3 and CXCR4 in 58 human cell lines.
We also detected increased aldehyde dehydrogenase (ALDH) activity associated with overexpression of specific ALDH isoform 1A3. Its inhibition by siRNA approach partially sensitized cells to various agents, thus linking for the first time the ALDH1A3 and chemoresistance in colorectal cancer.
Data indicate that aldehyde dehydrogenase 1A3 (ALDH1A3), that is directly involved in therapy resistance of glioblastoma, is regulated by autophagy during chemotherapy.
ALDH1A3 suppression could be one of PPARG tumor suppressive function. This study provides a better understanding of the role of PPARG in lung cancer.
Here the authors report the first crystal structure of human ALDH1A3 complexed with NAD(+) and the product all-trans retinoic acid (REA). The tetrameric ALDH1A3 folds into a three domain-based architecture highly conserved along the ALDHs family. The structural analysis revealed two different and coupled conformations for NAD(+) and REA that the authors propose to represent two snapshots along the catalytic cycle.
Data show that retinoic acid receptor responder 1 (RARRES1) expression is subtype-dependent and regulated by DNA methylation and the expression of aldehyde dehydrogenase 1A3 (ALDH1A3).
ALDH1A3 is a poor prognostic factor for patients with intrahepatic cholangiocarcinoma who underwent hepatectomy and in those with advanced intrahepatic cholangiocarcinoma receiving chemotherapy.
high transcription activities of ALDH1A2, ALDH1A3 and ALDH1L1 predicted worsen overall survival in gastric cancer patients
Melanoma treatment with the novel irreversible isoform-specific ALDH1 inhibitor [4-dimethylamino-4-methyl-pent-2-ynthioic acid-S methylester] di-methyl-ampal-thio-ester (DIMATE) or depletion of ALDH1A1 and/or ALDH1A3, promoted the accumulation of apoptogenic aldehydes leading to apoptosis and tumor growth inhibition in immunocompetent, immunosuppressed and patient-derived xenograft mouse models.
these findings ascribe a novel function for ALDH1A3 in an aggressive glioma stem cells phenotype via the up-regulation of tissue transglutaminase
our findings define a FOXD1-ALDH1A3 pathway in controling the clonogenic and tumorigenic potential of mesenchymal glioma stem-like cells in glioblastoma tumors
we looked up our single center primary prostate cancer post-operative follow-up data and suggested that the high level ALDH1A3 expression could predict the poor progression-free survival in a 158-patient cohort. We concluded that ALDH1A3, localized in luminal layer in prostate epithelium, is highly expressed in prostate cancer
this report brings new information for the phenotype-genotype correlation of ALDH1A3 mutations and raises important questions, especially in terms of genetic counselling given to the patients and their families
ALDH1A3 was most relevant to extracellular matrix organization and cell adhesion biological process, and the ability of tumor invasion was suppressed after ALDH1A3 knockdown in vitro.
the prevalence of ALDH1A3(+)/CD44(+) tumor cells in breast cancer is significantly associated with worse prognostic factors and favors a poor prognosis
Whole-exome sequencing in a South American cohort links ALDH1A3, FOXN1 and RARB/retinoic acid regulation pathways to autism spectrum disorders.
we demonstrated that a specific ALDH isoform, namely ALDH1A3, is enriched in chemoresistant mesothelioma cell subpopulations
ALDH1A3 induces differential RA signaling in breast cancer cells which affects the rate of breast cancer progression.
the distribution of RALDH1, RALDH2, and RALDH3 in the postnatal eye was determined.
ALDH1A3 is a target of miR-187 in human prostate cancer.
Study in diabetic mice reports the discovery of ALDH1A3 isoform as a biomarker of dysfunctional beta cells.
This study identifies Sam68 as a key regulator of neural progenitor cell self-renewal and establishes a novel link between modulation of ALDH1A3 expression and maintenance of high glycolytic metabolism in the developing cortex.
Chromatin immunoprecipitation assay using RarB as the immunoprecipitation target suggests retinoic acid regulation of Aldh1a3 and Foxn1 in mice.
Data suggest that expression of Aldh1a3/Raldh3 in placenta plays role in differentiation/placentation of glycogen trophoblast cells (junctional zone cells) via production of a local source of retinoic acid.
Raldh1 and Raldh3 influence enteric nervous system structure and function and heterozygosity for Raldh2 causes ENS defects
ALDH1A3 and ALDH2 expression was detectable in ALDH(very-br) and ALDH(br) cells, unlike ALDH(dim) cells, albeit at lower levels compared with ALDH1A1 and ALDH1A2.
regulation of fat depots through the concerted action of Aldh1 enzymes establishes retinoic acid-dependent tandem regulation of transcription factors ZFP423 and PPARgamma in a depot-specific manner
Kinetic characterization of RALDH3 and 4, providing their specificities for retinal isomer substrates.
Raldh2 and Raldh3 are selectively expressed in cortical stroma and in the ureteric bud during kidney development.
Three retinaldehyde dehydrogenases (RALDH1, RALDH2 and RALDH3), show differential expression patterns throughout later mouse organogenesis
RALDH3 is transiently expressed during early postnatal cortical development, suggesting an important role in cortical neuronal development.
RA-generating activities in Raldh2-null mouse embryos could be ascribed to RALDH3 in eye, nasal, and inner ear epithelia, and within the mesonephric area that expresses RALDH3.
Raldh3 knockout suppresses retinoic acid synthesis and causes malformations restricted to ocular and nasal regions
The expression patterns of aldh1a2 and aldh1a3 retinoic acid synthesizing enzymes at specific follicular sites suggest that they mediate and are regulated by different epithelial proliferation and differentiation signaling pathways.
RALDH3 (retinal dehydrogenase 3) was characterized by kinetic and binding studies, protein engineering, homology modelling, ligand docking and electrostatic-potential calculations.
During the first postnatal week, the RALDH3-expressing territory translocates in the caudal cortex from the medial limbic lobe to the adjacent neocortex and requires the neurotrophin NT-3.
the role of retinoic acid during forebrain development begins late when Raldh3 expression initiates in the ventral subventricular zone
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this gene uses retinal as a substrate, either in a free or cellular retinol-binding protein form.
aldehyde dehydrogenase 1A3
, aldehyde dehydrogenase 1 family, member A3
, aldehyde dehydrogenase family 1 subfamily A3-like
, aldehyde dehydrogenase family 1 member A3
, retinaldehyde dehydrogenase family 1 subfamily A3
, aldehyde dehydrogenase family 1 member A3-like
, acetaldehyde dehydrogenase 6
, aldehyde dehydrogenase 6
, retinaldehyde dehydrogenase 3
, aldehyde dehydrogenase family 1, subfamily A3
, aldehyde dehydrogenase-6