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anti-Human DDX39B Anticorps:
anti-Mouse (Murine) DDX39B Anticorps:
anti-Rat (Rattus) DDX39B Anticorps:
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Human Monoclonal DDX39B Primary Antibody pour CyTOF, ELISA - ABIN4363868
Boehringer, Garcia-Mansfield, Singh, Bakkar, Pirrotte, Bowser: ALS Associated Mutations in Matrin 3 Alter Protein-Protein Interactions and Impede mRNA Nuclear Export. dans Scientific reports 1970
Study showed that a genetic variant in the 5' UTR (Montrer UTS2R Anticorps) of DDX39B (Montrer DDX39 Anticorps) reduces translation of DDX39B (Montrer DDX39 Anticorps) mRNAs and increases multiple sclerosis (MS) risk. Importantly, this DDX39B (Montrer DDX39 Anticorps) variant showed strong genetic & functional epistasis with allelic variants in IL7R (Montrer IL7R Anticorps) exon 6; study establishes the occurrence of biological epistasis in humans & provides mechanistic insight into the regulation of IL7R (Montrer IL7R Anticorps) exon 6 splicing & its impact on MS risk.
DDX39B (Montrer DDX39 Anticorps) and its paralog DDX39A (Montrer DDX39 Anticorps) regulate androgen receptor (Montrer AR Anticorps) splice variant AR-V7 generation
Distinct features of RNA influence and ATPase (Montrer DNAH8 Anticorps) efficiency between UAP56 and TcSub2 may reflect distinct structures for functional sites of TcSub2. For this reason, ligand-based or structure-based methodologies can be applied to investigate the potential of TcSub2 as a target for new drugs.
However, no significant association was observed between the DDX39B (Montrer DDX39 Anticorps) -22 G/C polymorphism in the cases and controls. Furthermore, it is clarified that the protective effect of IL-4 (Montrer IL4 Anticorps) -590 is independent from APOE (Montrer APOE Anticorps) protective genotypes
The G allele of DDX39B (Montrer DDX39 Anticorps)-22C > G was associated with absent or decreased manifestations of vivax malaria and the C allele was a risk factor for disease complications.
We unravel the role of unexplored immunologically important genes, BAT1 (Montrer DDX39 Anticorps) and BTNL2 (Montrer BTNL2 Anticorps), and the haplotypes of the significantly associated SNPs therein, to understand susceptibility to the disease, leprosy and its differential severity.
these data identify UAP56 as an important binding partner of Bcr (Montrer BCR Anticorps) and a novel target for inhibiting vascular smooth muscle cell proliferation.
UAP56 and URH49 (Montrer DDX39 Anticorps) exhibit an intrinsic CRM1 (Montrer XPO1 Anticorps)-independent nucleocytoplasmic shuttling
Mx proteins exert their antiviral activity against IAV by interfering with the function of the RNA helicases UAP56 and URH49 (Montrer DDX39 Anticorps)
In summary, these data demonstrate that UAP56 is utilized by influenza A viruses to prevent the formation of dsRNA and, hence, the activation of the innate immune response.
These results imply that murine leukemia virus requires UAP56, THOC5 (Montrer THOC5 Anticorps) and THOC7 (Montrer THOC7 Anticorps), in addition to NXF1 (Montrer NXF1 Anticorps), for nuclear export of viral transcripts.
This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene.
56 kDa U2AF65-associated protein
, ATP-dependent RNA helicase p47
, HLA-B-associated transcript 1 protein
, nuclear RNA helicase (DEAD family)
, spliceosome RNA helicase BAT1
, spliceosome RNA helicase DDX39B
, DEAD box protein UAP56
, DEADD box protein
, HLA-B associated transcript 1
, HLA-B-associated transcript 1A
, nuclear RNA helicase Bat1
, spliceosome RNA helicase Bat1
, spliceosome RNA helicase Ddx39b
, HLA-B associated transcript 1A
, Nuclear RNA helicase