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The in vitro assays demonstrate the binding of the C-terminus of AtGCN2 to uncharged tRNA molecules and the enzymatic activities of AtGCN2 on both eIF2alpha homologues in A. thaliana.
HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF-2a ubiquitylation and degradation.
POSTN (Montrer POSTN Protéines) may function as a protective factor for osteoblasts during this process by inhibiting the eIF2alphaATF4 pathway.
findings indicate that MSI1 (Montrer MSI1 Protéines) plays a leading role in stress granule formation that grants cancer stem cell properties and chemoresistant stress granules in GBM, in response to stressful conditions via the PKR (Montrer PKLR Protéines)/eIF2alpha signalling cascade.
There was no statistically significant difference in IFN therapeutic effectiveness among the patients with different genotypes of eIF-2a (Montrer EIF2S1 Protéines)-reg2 (Montrer FLOT1 Protéines).
ER stress is induced early in EAE and that modulation of ER stress by inhibition of eIF2alpha-CHOP (Montrer DDIT3 Protéines) and activation of XBP-1 (Montrer XBP1 Protéines) in RGC specifically, protects RGC somata and axons and preserves visual function.
alpha-asarone abrogated 7beta-hydroxycholesterol-triggered eIF2alpha-CHOP (Montrer DDIT3 Protéines) activation, and enhanced macrophage beclin1 (Montrer BECN1 Protéines) dependent autophagy.
In response to endoplasmic reticulum stress, activation of PERK (Montrer EIF2AK3 Protéines) coordinates the integrated stress response by phosphorylating eIF2alpha, which is then quickly dephosphorylated by the GADD34 (Montrer PPP1R15A Protéines) complex. Data imply dual role of the ISR in promoting and inhibiting medulloblastoma tumorigenesis.
stress granule formation is a downstream event of eIF2alpha phosphorylation that may not directly protect cells from apoptosis, at least in spermatocytes of seminiferous tubules in early stages.
results further extended the understanding of Heme-regulated eIF2alpha kinase on the regulation of non-erythroid lineages and might provide new aspects for preventing and treating Cd-induced detrimental effects
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a phosphorylation by inhibiting PPP1CA (Montrer PPP1CA Protéines) via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (Montrer ATF4 Protéines) expression. (eIF2a = eukaryotic initiation factor-2alpha (Montrer EIF2S1 Protéines); PPP1CA (Montrer PPP1CA Protéines) = protein phosphatase 1 catalytic subunit alpha; Atf4 (Montrer ATF4 Protéines) = activating transcription factor 4 (Montrer ATF4 Protéines))
Results mechanistically link multiple forms of dystonia and put forth a new overall cellular mechanism for dystonia pathogenesis, impairment of eIF2alpha signaling, a pathway known for its roles in cellular stress responses and synaptic plasticity.
The eIF2A knock out mice strain is viable and to date displays no apparent phenotype.
Thus, during addiction, cocaine hijacks translational control by p-eIF2alpha, initiating synaptic potentiation and addiction-related behaviors.
Both DrPKZ-A and DrPKZ-B isoforms functionally interact with eIF2alpha and inhibit protein synthesis in Danio rerio.
Taken together, these results demonstrate that Porcine reproductive and respiratory syndrome virus infection induces host translation shutoff and that nsp2 (Montrer RTN2 Protéines) is associated with this process. Both eIF2alpha phosphorylation and the attenuation of the mTOR (Montrer FRAP1 Protéines) signaling pathway contribute to the virus-induced host translation arrest.
Therapeutic modulation of eIF2alpha (Montrer EIF2S1 Protéines) phosphorylation rescues TDP-43 (Montrer TARDBP Protéines) toxicity in amyotrophic lateral sclerosis disease models.
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002
65 kDa eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A
, Eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A, 65kDa
, eukaryotic translation initiation factor
, eukaryotic translation initiation factor 2A-like
, eukaryotic initiation factor 2alpha
, eukaryotic translation initiation factor 2
, eukaryotic translation initiation factor 2alpha
, minute (1) 14C