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Human NPM1 Protein expressed in Wheat germ - ABIN1312882
Xu, Fang, Dhar, St Clair, Kasarskis, St Clair: The role of a single-stranded nucleotide loop in transcriptional regulation of the human sod2 gene. dans The Journal of biological chemistry 2007
Show all 2 Pubmed References
Nucleophosmin (NPM1) was identified as a binding partner of DDX27 which increased NPM1 protein nuclear translocation. Its knockdown abrogated DDX27-mediated NF-kappaB signaling and colorectal cancer cell growth.
The NPM1 gene was the most frequently mutated gene in both white blood cells and cell-free DNA in healthy individuals.
NPM1 protein could promote more cells to enter S phase
A novel NPM1-interacting motif occurs in the C-terminal region of p14arf, which corresponds to its predicted nucleolar localization signal. This motif recognizes a specific region of the NPM1 N-terminal domain and, upon binding, the 2 proteins form soluble high molecular weight complexes.
NPM1 and SURF6 form heterotypic liquid-like droplets in the nucleolus.
High NPM1 expression is associated with tongue neoplasms.
his meta-analysis indicated that NPM may act as a valuable prognosis biomarker and a potential therapeutic target in human solid tumors.
this paper shows that viral nucleocapsid interacts with NPM1 and protects it from proteolytic cleavage, enhancing Cell survival, and is involved in porcine epidemic diarrhea virus growth
DNMT3A R882 mutation plays an important role in CN-AML patients' prognosis and clinical outcomes in the presence and absence of NPM1 and FLT3 mutations.
Mutation in NPM1 gene is associated with Acute Myeloid Leukemia.
Nucleoplasmic translocation of NPM1 is a prerequisite for stress-induced activation of p53.
NPM1 gene B type mutation enhanced the proliferation and invasion of THP-1 AML cells through the regulation of TIMP-2, MMP-2, Ang-1, c-myc and CCND1
In this study, FLT3 and NPM1 mutations were evaluated in adult Iranian patients with de novo cytogenetically normal acute myeloid leukemia and its correlations with clinical and laboratory parameters were also assessed.
These observations demonstrated that the expression and localization of NPM affected the homeostatic balance of oxidative stress in tumor cells via PRDX6 protein. The regulation axis of NPM/PRDX/ROS may provide a novel therapeutic target for cancer treatment.
In the Title.
ese results enhance our understanding of the molecular mechanisms that govern nucleoli formation by demonstrating that PPM1D regulates nucleolar formation by regulating NPM phosphorylation status through a novel signalling pathway, PPM1D-CDC25C-CDK1-PLK1
Data suggest that the direct interaction of several regions of nucleophosmin 1 (NPM1) C-terminal domain (CTD) with cellular membranes could be implicated in diseases where NPM1 is mutated and/or where its overexpression is cytoxic.
Mechanically, mutant NPM1 interacted with PML and mediated its delocalization as well as stabilization contributing to elevated autophagic activity and leukemic cell survival in vitro.
Mutation analysis in NPM1 in acute myeloid leukemia.
We conclude that the degradation of NPM1 and HEXIM1 through autophagy in certain AML subsets contributes to the activation of the BET pathway in these cells.
In the current study, we demonstrate the existence of a negative feedback loop through which an increased B23 expression suppresses ERalpha. Because suppression of ERalpha expression is a late event during estrogen-dependent endometrial tumorigenesis, the inhibition of nucleophisminmay represent a strategy to promote ERalpha re-expression that ultimately restores tumor sensitivity to hormonal therapy
molecular complementarity underlies the higher frequency and significantly worse prognosis associated with NPM1c/FLT3-internal tandem duplications vs NPM1/NRAS-G12D-mutant acute myeloid leukemia (AML) and functionally confirm the role of HOXA genes in NPM1c-driven AML.
NPM1-dependent nucleolar PIDDosome is a key initiator of the caspase-2 activation cascade.
NPM1 knockdown decreased NF-kappaB-mediated transcription of selected target genes by decreasing the recruitment of NF-kappaB p65 to the gene promoters.
study suggests that although neurons need NPM1 for survival, an increase in its expression beyond physiological levels and its translocation to the cytoplasm leads to death through abortive cell cycle induction.
The levels of B23 expression are directly regulated by EGR1.
IDH2 and NPM1 mutations synergize in the development and maintenance of acute myeloid leukemia stem-like cells.
Lrrc34, a novel nucleolar protein, interacts with npm1 and ncl and has an impact on pluripotent stem cells
a function of NPM1 in the spatial organization of nucleolus-associated heterochromatin through DNA methyltransferase DNMT3A
The data presented here support a novel role for NPM1 as a multilevel modulator of the base excision repair pathway.
The mechanism of G-CSF's neuroprotection may be related in part to attenuating neuronal apoptosis by NPM1.
In conclusion, we successfully established xenotransplantation model of human FLT3-ITD (mut) /NPM1 (-) CN-AML in NOD/SCID mice.
This in vivo model of Flt3/ITD+/NPMc+ leukemia closely recapitulates human disease and will therefore serve as a tool for the investigation of the biology of this common disease entity
HOPS acts as a functional bridge in the interaction between NPM and p19(Arf)
NPM-Bax interaction enhances mitochondrial Bax accumulation, organelle injury, and cell death.
These results suggest that the down-regulation of the identified nucleophosmin proteins in QRsP-11 cells compared to QR-32 cells is possibly related to tumor malignant progression.
Overexpression of Npm1 in mice results in myeloproliferation and implies a perturbation in hematopoietic microenvironment.
The B23 regulates neuronal survival by preventing SIAH1-GAPDH death signaling under stress-induced conditions in the brain.
the aberrant feed-forward pathway that keeps eIF4E and C/EBPalphap30 elevated in NPM1(+/-) cells contributes to the MDS phenotype associated with NPM1 deficiency.
level of Npm1 expression has a role in regulating hematopoietic stem cell numbers in the bone marrow.
Depletion of B23 expression inhibits virus production by BIV-infected cells, indicating that B23 plays an important role in BIV replication.
Results suggest that some polymorphisms in NPM1 are associated with body weight at some ages and may be used as candidates for marker-assisted selection and management in beef cattle breeding programmes.
The NPM1 gene is a candidate gene for growth traits in cattle.
NLP is essential for the positioning of centromeres during cell division in Drosophila.
This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
nucleolar protein NO38
, nucleophosmin/nucleoplasmin family, member 1
, nucleolar phosphoprotein B23
, nucleolar protein B23.1
, nucleophosmin 1
, nucleophosmin/nucleoplasmin, 4
, chromatin decondensation protein 1
, nucleophosmin 1a (nucleolar phosphoprotein B23, numatrin)