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Formation of the nineteen complex core by stepwise assembly of SPF27, CDC5L, and PLRG1 onto the Prp19 tetramer enables ubiquitin ligation.
This work implies that the gain of Prp19 is a critical event during the progression of hepatocellular carcinoma
These results demonstrate that SNEV regulates adipogenesis in hASCs and indicate that DDR capacity in general might be a pre-requisite for this process.
the interactome of influenza A virus NS1 in host cells was comprehensively profiled, and our findings reveal a novel regulatory role for PRP19 in viral replication
Crystal structure revealed features of the WD40 domain of human PRPF19.
The results suggest that RPA phosphorylation enhances the recruitment of PRP19 to RPA-ssDNA and stimulates RPA ubiquitylation through a process requiring both PRP19 and RFWD3, thereby triggering a phosphorylation-ubiquitylation circuitry that promotes ATR activation and homologous recombination.
role of Pso4 in DNA repair and DNA damage
Study demonstrates that the levels of Prp19 and Cdc5L are overexpressed in hepatocellular carcinoma (HCC). Prp19 binds with Cdc5L and its downregulation results in reduction of Cdc5L. Mechanistic insights reveal that silencing Prp19 compromises translation activity of Cdc5L and facilitates lysosome-induced degradation of Cdc5L in HCC cells.
We report that PRP19 expression is elevated in lung carcinoma tissues compared to non-tumor tissues
These findings suggest that SKAP promotes ultraviolet rays-induced cell apoptosis by negatively regulating the anti-apoptotic protein Prp19.
involvement of hPso4 in the recombinational repair of DSBs
DNA damage induces down-regulation of Prp19 via impairing Prp19 stability in hepatocellular carcinoma cells.
The Prp19-CDC5L complex plays a crucial role during human pre-mRNA splicing by catalytic activation of the spliceosome.
Prp19 complex as the first spliceosome subcomplex that directly contributes to mitosis in vertebrates independently of its function in interphase.
PRP19 directly binds RPA and localizes to DNA damage sites via RPA, promoting RPA ubiquitylation in a DNA-damage-induced manner.
New insights into pre-mRNA processing factor 19
PRP19 over-expression is associated with hepatocellular carcinoma recurrence.
SNEV phosphorylation at S149 is essential for mediating the cytoprotective effect of SNEV upon DNA damage/oxidative stress and partially contributes to the life span extension caused by SNEV overexpression.
U2AF65 binds directly to the phosphorylated C-terminal domain, and that this interaction results in increased recruitment of U2AF65 and PRP19C to the pre-mRNA
hPso4, once it forms a complex with Metnase, negatively regulates Metnase's TIR binding activity
SNEV(P) (rp19/) (PSO) (4) deficiency increases PUVA-induced senescence in mouse skin
the alpha-variant of Prp19 gene plays a pivotal role in neural differentiation and that the beta-variant participates in neuronal/astroglial cell fate decisions
Down-regulation of Prp19p expression with RNA interference in 3T3-L1 cells repressed lipid droplet formation with the reduction in the level of expression of perilipin and S3-12
SNEV is indispensable for early mouse development; MEFs (mouse embryonic fibroblasts) with reduced SNEV levels have lowered proliferative potential.
Immunofluorescence microscopy revealed that a domain of amino acids 167-250 is necessary for the recruitment of Prp19p to lipid droplets and that a domain of amino acids 1-166 is necessary for the recruitment of Prp19p to a nucleus.
The expression of SNEV is closely associated with the growth of murine hematopoietic stem cells (HSCs) and determines the proliferative and repopulating capacity of phenotypically defined HSC subsets.
The knockdown of PRPF19 or EIF4A3 decreased splicing of Lhb, or of both beta subunit transcripts, respectively.
PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008
pre-mRNA-processing factor 19
, nuclear matrix protein NMP200 related to splicing factor PRP19
, PRP19/PSO4 pre-mRNA processing factor 19 homolog
, PRP19/PSO4 homolog
, nuclear matrix protein 200
, senescence evasion factor
, neuronal differentiation-related gene protein
, pre-mRNA processing factor 19
, nuclear matrix protein SNEV
, prp19 beta