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Dog (Canine) Polyclonal SART3 Primary Antibody pour IHC, WB - ABIN2780944
Liu, Li, Kim, Pace, He: HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110. dans The Journal of biological chemistry 2002
Show all 2 Pubmed References
Cow (Bovine) Polyclonal SART3 Primary Antibody pour WB - ABIN2780945
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... dans Molecular systems biology 2007
Human Polyclonal SART3 Primary Antibody pour ELISA, WB - ABIN250557
Bell, Schreiner, Damianov, Reddy, Bindereif: p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor. dans The EMBO journal 2002
Data suggest that ZIP (Montrer DAPK3 Anticorps), USP39 (Montrer USP39 Anticorps), Prp24/p100/SART3, and Prp43 (Montrer DHX15 Anticorps) associate to form complex instrumental in spliceosome assembly; ZIP (Montrer DAPK3 Anticorps) regulates pre-mRNA splicing of USP39 (Montrer USP39 Anticorps) independent of RNA binding; stable 35S tri (Montrer VANGL2 Anticorps)-snRNP (Montrer LSM2 Anticorps) particles are enriched in Cajal body. (ZIP (Montrer DAPK3 Anticorps) = zinc finger and G-patch domain-containing protein (Montrer ZGPAT Anticorps); USP39 (Montrer USP39 Anticorps) = ubiquitin specific peptidase 39 (Montrer USP39 Anticorps); Prp43 (Montrer DHX15 Anticorps) = RNA helicase (Montrer DDX46 Anticorps) Prp43 (Montrer DHX15 Anticorps))
We show that PRP31 (Montrer PRPF31 Anticorps), a component of U4 snRNP (Montrer LSM2 Anticorps), is modified with K63-linked ubiquitin chains by the PRP19 (Montrer PRPF19 Anticorps) complex and deubiquitinated by USP15 (Montrer USP15 Anticorps) and its substrate targeting factor SART3. USP15SART3 makes a complex with USP4 (Montrer USP4 Anticorps) and this ternary complex serves as a platform to deubiquitinate PRP31 (Montrer PRPF31 Anticorps) and PRP3 (Montrer CLCA4 Anticorps)
The complex structure of SART3 nuclear localization signal (NLS (Montrer ALDH1A2 Anticorps)) and importin-alpha reveals bipartite binding, and removal of SART3 NLS (Montrer ALDH1A2 Anticorps) prevents the entry of USP4 (Montrer USP4 Anticorps) (and USP15 (Montrer USP15 Anticorps)) into the nucleus and abrogates the subsequent deubiquitinase activity of USP4 (Montrer USP4 Anticorps).
crystal structures of SART3 in the apo (Montrer C9orf3 Anticorps)-form and in complex with the DUSP (Montrer DUSP5 Anticorps)-UBL domain of USP15 (Montrer USP15 Anticorps) at 2.0 and 3.0 A, respectively. Structural analysis reveals SART3 contains 12 half-a-tetratricopeptide (HAT (Montrer MGEA5 Anticorps)) repeats, organized into two subdomains, HAT (Montrer MGEA5 Anticorps)-N and HAT (Montrer MGEA5 Anticorps)-C. SART3 dimerizes through the concave surface of HAT (Montrer MGEA5 Anticorps)-C, whereas the HAT (Montrer MGEA5 Anticorps)-C convex surface binds USP15 (Montrer USP15 Anticorps) in a novel bipartite mode.
miR (Montrer MLXIP Anticorps)-124 regulates Tip110 expression and differentiation of human cord blood CD34 (Montrer CD34 Anticorps)(+) cells
Hypoxia led to Tip110 protein degradation through the ubiquitin-proteasome system. Under hypoxia, Tip110 stabilized p53 (Montrer TP53 Anticorps), which in return destabilized Tip110.
SART3 recruits ubH2B, which may be evicted from DNA during transcription, for deubiquitination by Usp15 (Montrer USP15 Anticorps)
YB-1 (Montrer YBX1 Anticorps) potentiates the Tip110/Tat (Montrer TAT Anticorps)-mediated transactivation of the HIV-1 LTR promoter.
findings show C-MYC (Montrer MYC Anticorps) upregulates transcription of TIP110 through interaction with the TIP110 E-box in the TIP110 promoter, ensuring high-level Tip110 expression in proliferating embryonic stem cells (hESCs); further show TIP110 regulates OCT4 (Montrer POU5F1 Anticorps) alternative splicing in hESCs
TIP110 is also expressed in human embryonic stem cells (hESCs) and expression was decreased with differentiation of these ESCs (Montrer NR2E3 Anticorps).
The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.
squamous cell carcinoma antigen recognized by T cells 3
, Squamous cell carcinoma antigen recognized by T-cells 3
, squamous cell carcinoma antigen recognized by T-cells 3-like
, earl grey
, squamous cell carcinoma antigen recognized by T-cells 3
, tat-interacting protein of 110 kDa
, tumor-rejection antigen SART3