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anti-Human ATP2B1 Anticorps:
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Amphibian Monoclonal ATP2B1 Primary Antibody pour FACS, ICC - ABIN152735
Krizaj, Liu, Copenhagen: Expression of calcium transporters in the retina of the tiger salamander (Ambystoma tigrinum). dans The Journal of comparative neurology 2004
Show all 8 Pubmed References
Human Polyclonal ATP2B1 Primary Antibody pour ELISA, WB - ABIN4346333
Benetti, Mičetić, Carsughi, Spinozzi, Bubacco, Beltramini: Insights into the oligomerization process of the C-terminal domain of human plasma membrane Ca²+-ATPase. dans Archives of biochemistry and biophysics 2011
enhanced eNOS activity induced by ATP2B1 gene silencing may be mediated via higher levels of intracellular Ca(2+), and the effect was confirmed to be dependent on the eNOS-calmodulin interaction
rs17249754-A (OR = 0.43, p = 0.0002) and rs1401982-G (OR = 0.47, p = 0.0007) were associated with decreased susceptibility of concurrent extra and intracranial stenosis even after Bonferroni correction. These two minor alleles were also significantly associated with less stenotic arteries and moderate-to-severe stenosis.
Cryoelectron microscopy reveals the PMCA1 structure in complex with neuroplastin.
people with the major allele of ATP2B1 rs17249754 are susceptible to hypertension especially in low intake of Ca and high ratio of Na and K
Crossover analysis and stratified analysis indicated that BMI has a major effect on the development of hypertension, while ATP2B1 variants have a minor effect
Excessive sodium intake significantly modified the risk of developing Hypertension associated with ATP2B1 rs17249754 genetic trait. Homozygote carriers may be at higher risk of hypertension, when they consume excessive sodium intake.
Data show that plasma membrane Ca(2+)-ATPase (PMCA) was associated with tubulin in normotensive and hypertensive erythrocytes.
rs11105378 near ATP2B1 was associated with increased systolic and diastolic blood pressure in a Chinese population.
ATP2B1 rs12817819 A allele is associated with increased risk for drug resistant hypertension.
While PMCA1b has a housekeeping function in colon cancer cells, PMCA4b participates in the reorganization of the calcium signaling machinery during cell differentiation.
Report that ATP2B1 rs2681472 is associated with early-onset preeclampsia in Northern Han Chinese women.
An increase of phosphatidylcholine/detergent molar ratio leads to a biphasic behavior of the PMCA Ca2+-ATPase activity, whose maximum depends on phosphatidylcholine characteristics.
The present study confirmed the significant association of ATP2B1 rs17249754 with risk of hypertension among Chinese children.
The downregulation of PMCA1 and the disruption of calcium homeostasis may play important roles in UVB-induced HLE B-3 cell apoptosis.
analysis of how human plasma membrane Ca2+ pump PMCA h4xb is hyperactivated by mutation of Glu99 to Lys
Association of the ATP2B1 gene and susceptibility to hypertension, blood pressure traits and carotid-femoral pulse wave velocities in a Chinese population.
Polymorphism near the ATP2B1 gene is associated with hypertension risk in East Asians.
The authors provide data revealing both functional and physical links between the activation of stromal interacting molecule 1 (STIM1) and PMCA-mediated Ca(2+) clearance.
Immunohistochemical analysis of the distribution of TRPV6 and PMCA1 in the uterus revealed that both proteins are abundantly expressed in the cytoplasm of endometrial and glandular epithelial cells during menstrual phases.
Cloned the C-terminal domain of the human PMCA isoform 1b, and characterized its properties in solution. The expressed protein maintains its tendency to oligomerize in aqueous solutions, but it is dissociated by amphipathic molecules.
increased intracellular calcium concentration in vascular smooth muscle cells due to lack of ATP2B1 and subsequent activation of L-type calcium channels mainly affects blood pressure and suggests increased susceptibility to calcium channel blockers
These results suggest that renal PMCA1 has a role as one of the molecules involved in angiotensin II-induced hypertension and kidney injury.
PMCA1 is required for maintaining atrial Ca(2+) homeostasis and electrical stability.
Decreased expression of PMCA1 is associated with increased blood pressure when combined with advancing age.
Deletion of the Pmca1 in the intestine is associated with reduced growth and bone mineralization, and a failure to up-regulate calcium absorption in response to 1alpha,25(OH)2D3.
decreased ATP2B1 gene expression is associated with impaired endothelial NOS activity and nitric oxide production, and the ATP2B1 gene plays a crucial role in the regulation of blood pressure
ATP2B1 is the causative gene in the blood pressure-associated 12q21 locus; ATP2B1 expression in the vessel influences blood pressure
ATP2B1 plays important roles in the regulation of blood pressure through alteration of calcium handling and vasoconstriction in vascular smooth muscle cells.
Cav1.4alpha1 is required for proper targeting of the presynaptic PMCA1 complex in retinal photoreceptors.
the decapacitation mechanism of the SVA might target membrane sphingolipid SPM and regulate PMCA activity to lower [Ca(2+)](i), thereby decreasing the [cAMP](i) level and preventing sperm pre-capacitation.
Plasma membrane Ca2+-ATPase and NCX1 Na+/Ca2+ exchanger expression in distal convoluted tubule cells mediate calcium efflux.
Mouse photoreceptors, cone bipolar cells and horizontal cells, which respond to light with a graded polarization, express isoform PMCA1
results are consistent with an essential housekeeping or developmental function for plasma membrane Ca2+-ATPase (PMCA)1
Data indicate that plasma membrane Ca(2+)-ATPases 1 and 4, in addition to SERCA2 and NCX, play a significant role in both excitation-contraction coupling and calcium homeostasis in bladder smooth muscle.
PMCA1 isoform is involved in overall Ca(2+) clearance, while PMCA4 is essential for [Ca(2+)](i) increase and contractile response to carbachol receptor-mediated signal transduction pathway.
PKA-mediated phosphorylation of PMCA1 differentially regulates [Ca(2+)](i) clearance in the apical region of parotid acinar cells because of a dynamic translocation of PKA
Data suggest that both scaffold proteins PSD95beta and MPP4 are essential for the modulation of PMCA levels at the presynaptic plasma membrane and thereby influence the photoreceptor synaptic calcium handling.
Adding pure bovine MMP-2 to the smooth muscle membrane suspension causes an increase in Ca(2+)-ATPase activity, but the pretreatment with TIMP-2 inhibits the increase in the enzyme activity
To demonstrate the subcellular localization and regulation of bovine sperm PMCA, cell fractionation, enzyme activity determination and Western blotting studies of PMCA in spermatozoa removed from the cauda epididymidis of bull, was performed.
Purified plasma membrane Ca2+ ATPase was able to hydrolyze ATP at a very low rate in the absence of Ca2+.
results suggest that the activating mechanism of ethanol may involve opening an autoinhibitory domain located close to the calmodulin binding domain
ceramide activates plasma membrane Ca2+-ATPase from kidney-promixal tubule cells with protein kinase A as an intermediate
Activity of Atp2b1a is required to facilitate calcification of the developing pharyngeal teeth by the dental epithelium.
Atp2b1a functions during progenitor cell proliferation and hair cell differentiation
Atp2b1a plays an important role for normal development of the auditory and vestibular system as well as calcium transport in the inner ear of zebrafish.
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified.
plasma membrane calcium pump
, plasma membrane calcium-transporting ATPase 1
, plasma membrane calcium ATPase
, plasma membrane calcium ATPase 1
, Ca2+/Mg2+ ATPase
, ATPase, Ca++ transporting, plasma membrane 1
, plasma membrane calcium-transporting ATPase 1-like
, plasma membrane Ca2+ pump (PMCA1b)
, ATPase, Ca++ transporting, plasma membrane 1 L homeolog
, plasma membrane calcium ATPase 1b