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anti-Human IMPDH2 Anticorps:
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Human Polyclonal IMPDH2 Primary Antibody pour IHC, IHC (p) - ABIN4325727
Floryk, Thompson: Antiproliferative effects of AVN944, a novel inosine 5-monophosphate dehydrogenase inhibitor, in prostate cancer cells. dans International journal of cancer 2008
Show all 4 Pubmed References
Human Monoclonal IMPDH2 Primary Antibody pour IP, RNAi - ABIN561488
Nogueira da Costa, Mijal, Keen, Findlay, Wild: Proteomic analysis of the effects of the immunomodulatory mycotoxin deoxynivalenol. dans Proteomics 2011
Human Polyclonal IMPDH2 Primary Antibody pour ELISA, WB - ABIN449844
Fellenberg, Bernd, Delling, Witte, Zahlten-Hinguranage: Prognostic significance of drug-regulated genes in high-grade osteosarcoma. dans Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2007
Study verified that overexpressing IMPDH2 could promote G1/S phase cell cycle transition through activation of PI3K/AKT/mTOR and PI3K/AKT/FOXO1 pathways and facilitate cell invasion, migration and EMT by regulating PI3K/AKT/mTOR pathway.
Our study demonstrates IMPDH2 may be served as an independent prognostic biomarker for NPC patients, in which high IMPDH expression suggests poor prognosis of NPC patients.
inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) is an intracellular target of the PPIA-Sanglifehrin A binary complex.
Rod and ring formation might be an adaptive homeostatic mechanism, allowing IMPDH to sense changes in the one-carbon folate pathway.
Taking together, these results indicate that natural product myricetin exhibits potent anti-leukemia activity by interfering with purine nucleotides biosynthetic pathway through the suppression of hIMPDH1/2 catalytic activity.
The findings suggest that overexpressed IMPDH2 can be used as a biomarker for kidney and bladder cancer diagnosis and is a potential therapeutic target for the diseases
IMPDH2 is directly involved in the development of chemoresistance and radioresistance in osteosarcoma cells.
Compared with non-cancerous prostate tissues, IMPDH2 mRNA and protein expression levels were both significantly upregulated in prostate cancer tissues.
Expression of IMPDH mRNA after mycophenolate administration in male volunteers.
the localization of IMPDH2 inside the nucleus of human cells as well as the ultrastructure of R&R inclusions
Rods and rings (RR) are protein assemblies composed of CTPS1 and IMPDH2. Glutamine deprivation initiates reversible assembly of mammalian rods and rings.
An insight to the dynamics of conserved water-mediated salt bridge interaction and interdomain recognition in hIMPDH isoforms.
Role of salt bridge dynamics in inter domain recognition of human IMPDH isoforms: an insight to inhibitor topology for isoform-II.
This ethnic-related data might contribute to a better understanding of the variability in clinical outcome and/or dose adjustments of drugs that are IMPDH inhibitors such as mycophenolic acid.
the 3757C allele was associated with higher lymphocyte counts and a reduced incidence of lymphopenia among kidney allograft recipients
Anti-IMPDH2 may cause difficulties in interpretation of immunofluorescence patterns in routine autoantibody testing.
IMPDHII plays an important role in the negative regulation of TLR2 signaling by modulating PI3K activity.
in the absence of ligand the mobilities of "flap" and "loop" regions of IMPDH-II (1B3O) structures are mostly controlled by the four (W 1, W 2, W 3, and W 4) conserved water molecular centers and their dynamics
resequenced IMPDH1 and IMPDH2 using DNA from 288 individuals from three ethnic groups and performed functional genomic studies of the sequence variants observed; identfied 25 SNPs, 24 novel, in IMPDH2
Potential associations between the most frequent single nucleotide polymorphisms in both IMPDH genes and clinical outcome in renal transplant recipients.
IMPDH2 mediated guanine nucleotide synthesis is essential for normal development of the enteric nervous system and other neural crest derivatives.
various carbon atom lengths and double bonds of fatty acids were examined for inhibitory strength; docking simulation of C20-fatty acids and mouse IMPDH type II was performed.
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
IMP (inosine monophosphate) dehydrogenase 2
, inosine monophosphate dehydrogenase 2
, IMP (inosine 5'-monophosphate) dehydrogenase 2
, inosine-5'-monophosphate dehydrogenase 2-like
, IMP oxireductase 2
, IMPD 2
, IMPDH 2
, inosine 5' phosphate dehydrogenase 2
, inosine monophosphate dehydrogenase type II
, inosine-5'-monophosphate dehydrogenase 2
, IMP dehydrogenase 2
, inosine 5'-phosphate dehydrogenase 2
, inosine 5-monophosphate dehydrogenase 2
, IMP dehydrogenase type II