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Knockdown of endogenous UCK2 as well as overexpression of UCK1 resulted in decreased metabolism of uridine and cytidine and protected neuroblastoma cells from 3-deazauridine-induced toxicity. Subcellular localization studies showed that UCK1-GFP and UCK2-GFP were localized in the cell nucleus and cytosol, respectively.
accumulation of RX-3117 nucleotides correlated with UCK2 expression.
UCK1 and 2 are both expressed in several neuroblastoma cell lines, including four MYCN single copy cell lines and five MYCN amplified cell lines
Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23.
Increased intranuclear levels of UK may contribute to the metabolic build-up that is needed for Epstein-Barr virus nuclear protein EBNA-3-mediated B-cell blast transformation and rapid proliferation.
UCK2 is responsible for phosphorylation and activation of the antitumor activity of 3'-ethynyl nucleosides 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine and 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine.
gene mapped to chromosome 1.
B4GALT3, DAP3, RGS16, TMEM183A and UCK2--were significantly overexpressed in dup(1q)-positive ALLs compared with high hyperdiploid ALLs without dup(1q).
The mechanism of phosphate transfer in UCK2 is shown to be concerted, and is accompanied by concerted proton transfer from the 5'-hydroxyl to a conserved active site aspartic acid that serves as a catalytic base
This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 220.127.116.11) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.
, cytidine monophosphokinase 2-B
, uridine monophosphokinase 2-B
, uridine-cytidine kinase 2
, uridine-cytidine kinase 2-B
, uridine phosphokinase
, uridine kinase
, Uridine kinase
, UCK 2
, cytidine monophosphokinase 2
, uridine monophosphokinase 2
, toxin secretion ABC transporter ATP-binding protein
, testis-specific protein TSA903
, uridine monophosphate kinase
, uridine monophosphate kinase 2