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there are inter-ethnic differences for uridine phosphorylase 1 (UPP1) and zinc finger-SWIM containing 4 (ZSWIM4) in response to 1alpha,25(OH)2D3
The dimeric enzyme is capable of a large hinge motion facilitating ligand exchange.
Data show that enhanced cytotoxicity of 5-FU by bFGF through modulating the expression of UPP1 at the transcription level.
The expression level of UPase gene may be an independent prognostic marker in human breast carcinoma
Characterization of the promoter region of UPase has indicated a direct regulation of its expression by the tumor suppressor gene p53. Review.
Uridine phosphorylase overexpression is associated with lymph node metastasis in oral neoplasms
Thymidine phosphorylase and uridine phosphorylase were both responsible for converting 5'dFUrd/5FU into 5FU/FUrd, respectively
The presented structures confirm that hUPP1 is dimeric. They also reveal the mechanism by which 5-benzylacyclouridine engages the active site of the protein and disables the enzyme by locking the protein in a closed conformation.
Importance of UPase in the activation of fluoropyrimidines, the effect of uridine in protecting normal tissues, and the role for tumor-specific modulation of the phosphorolytic activity in 5-FU or capecitabine-based chemotherapy.
Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice.
UPase is a critical enzyme in the regulation of uridine homeostasis and pyrimidine nucleotide metabolism, and 5-fluorouracil activity
Taken together, the present study provides the first evidence that uridine protects neurons against ischemic insult-induced neuronal death, possibly through the action of UPase.
Thymidine phosphorylase and UPP1 double knockout mice showed increased thymidine and deoxyuridine in tissues and developed encephalopathy.
The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP\; EC 220.127.116.11) and thymidine phosphorylase (TP\; EC 18.104.22.168), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995
uridine phosphorylase 1
, Uridine phosphorylase 1
, UPase 1
, urdPase 1