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anti-Mouse (Murine) CDH23 Anticorps:
anti-Human CDH23 Anticorps:
anti-Rat (Rattus) CDH23 Anticorps:
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Human Polyclonal CDH23 Primary Antibody pour ELISA, WB - ABIN449707
Roux, Faugère, Le Guédard, Pallares-Ruiz, Vielle, Chambert, Marlin, Hamel, Gilbert, Malcolm, Claustres: Survey of the frequency of USH1 gene mutations in a cohort of Usher patients shows the importance of cadherin 23 and protocadherin 15 genes and establishes a detection rate of above 90%. dans Journal of medical genetics 2006
Human Polyclonal CDH23 Primary Antibody pour ELISA, WB - ABIN566227
Apostolopoulou, Ligon: Cadherin-23 mediates heterotypic cell-cell adhesion between breast cancer epithelial cells and fibroblasts. dans PLoS ONE 2012
The results illustrate the large effects that the mouse strain background and congenic regions have on the hearing loss associated with Cdh23 alleles.
Many GABAergic interneurons, from their generation in the medial ganglionic eminence up to their settlement in the auditory cortex, express two cadherin-related (cdhr) proteins, cdhr23 and cdhr15 (Montrer PCDH15 Anticorps), that form the hair bundle tip links gating the mechanoelectrical transduction channels.
data suggest that CDH23-C is a CAMSAP3 (Montrer CAMSAP3 Anticorps)/Marshalin-binding protein that can modify MT networks indirectly through its interaction with CAMSAP3 (Montrer CAMSAP3 Anticorps)/Marshalin.
interactions of wild type (WT) and mutant variants of N-terminal fragments (EC1+2) of cadherin-23 and protocadherin-15 (Montrer PCDH15 Anticorps), two proteins essential for inner-ear mechanotransduction, are reported.
These results clearly show that the development of early-onset progressive hearing loss (ePHL) requires at least two mutant alleles of the Ush1g and Cdh23 genes. Our results also suggest that because the SANS and CDH23 proteins form a complex in the stereocilia, the interaction between these proteins may play key roles in the maintenance of stereocilia and the prevention of ePHL.
Our results showed that systemic treatment with TUDCA significantly alleviated hearing loss and suppressed hair cell death in erl(Cdh23) mice. Additionally.
This study further resolves the interaction between Atp2b2 (Montrer ATP2B2 Anticorps) and Cdh23 in a gene dosage and frequency-dependent manner, and finds that low auditory frequencies are significantly affected by the interaction.
crystallography, molecular dynamics simulations and binding experiments to characterize the protocadherin 15 (Montrer PCDH15 Anticorps)-cadherin 23 bond
A point mutation in the Cdh23 gene (208T>C) of C57BL/6J mice results in hearing loss around 1 month after birth.
the Cdh23(nmf308/nmf308) mice with progressive hair cell loss had specific morphological changes and suffered a base to apex gradient and age-related hearing loss (AHL), and that mutations in cdh23 were linked to AHL
We have identified CDH23 mutations as a genetic risk factor for both familial and sporadic pituitary adenoma.
an important contribution of CDH23 mutations to poslingual Sensorineural Hearing Loss
A new diagnosis of sector retinitis pigmentosa was found to have two novel compound heterozygous mutations in CDH23, including one missense (c.8530C > A; p.Pro2844Thr) and one splice-site (c.5820 + 5G > A) mutation.
Four (3.1 %) of 128 children carried two CDH23 mutant alleles, and SLC26A4 (Montrer SLC26A4 Anticorps) and GJB2 (Montrer GJB2 Anticorps) accounted for 18.0 and 17.2 %, respectively and showed profound nonsyndromic sensorineural hearing loss with minimal residual hearing.
The results revealed that CDH23 mutations are highly prevalent in patients with congenital high-frequency sporadic or recessively inherited hearing loss
Description of the spectrum of mutations in CDH23 in 374 families with autosomal recessive, non-syndromic hearing loss from India.
The results of this study confirm that CDH23 genetic variant may modify the susceptibility to noise-induced hearing loss development in humans
mutations in the CDH23 gene are one of the most important causes of non-syndromic hearing loss in East Asians.
Hearing loss was found to co-segregate with locus-specific STR (Montrer STATH Anticorps) markers for CDH23 in 1 Pakistani family.
This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Alternative splice variants encoding different isoforms have been described.
age related hearing loss 1
, modifier of deaf waddler
, cadherin-like 23
, cadherin-related family member 23
, cadherin 23 (otocadherin)
, cadherin related 23