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anti-Rat (Rattus) DFNA5 Anticorps:
anti-Human DFNA5 Anticorps:
anti-Mouse (Murine) DFNA5 Anticorps:
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DFNA5 variant is associated with tobacco- and HPV-mediated oral oncogenesis.
DFNA5 methylation shows strong potential as a biomarker for detection of breast cancer. Slightly increased methylation in histologically normal breast tissue surrounding the tumor suggests that it may be a good early detection marker.
In conclusion, our findings firstly revealed that GSDME switches chemotherapy drug-induced caspase-3 (Montrer CASP3 Anticorps) dependent apoptosis into pyroptosis in gastric cancer cells.
findings suggest that caspase-3 (Montrer CASP3 Anticorps) activation can trigger necrosis by cleaving GSDME and offer new insights into cancer chemotherapy
Genetic variations in the EYA4 (Montrer EYA4 Anticorps), GRHL2 (Montrer GRHL2 Anticorps) and DFNA5 genes and their interactions with occupational noise exposure may play an important role in the incidence of noise-induced hearing loss (NIHL).
Study identified a novel DFNA5 mutation IVS8+1 delG in a Chinese family which led to skipping of exon 8. This is the sixth DFNA5 mutation relates to hearing loss and the second one in DFNA5 intron 8.
We identified a novel c.991-2A>G mutation in DFNA5 which again may lead to exon 8 skipping at the mRNA level.
DFNA5 deletion mutation is associated with autosomal dominant hereditary hearing loss in Japanese families.
DFNA5 protein expression in hepatocellular carcinoma cells was significantly lower than that in normal cells.
DFNA5 is composed of two domains, separated by a hinge region. The first region induces apoptosis when transfected in HEK293T cells, the second region masks and probably regulates this apoptosis inducing capability
These results suggest that DFNA5 plays a role in the p53 (Montrer TP53 Anticorps)-regulated cellular response to genotoxic stress probably by cooperating with p53 (Montrer TP53 Anticorps).
The identification of the cochlear transcription initiation site (TIS (Montrer PDCD4 Anticorps)), the core promoter region between relative to the TIS (Montrer PDCD4 Anticorps) and an enhancer and a silencer element of Dfna5, is described.
Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene.
deafness, autosomal dominant 5
, deafness, autosomal dominant 5 homolog
, deafness, autosomal dominant 5 protein
, inversely correlated with estrogen receptor expression 1
, non-syndromic hearing impairment protein 5
, nonsyndromic hearing impairment protein
, hearing impairment protein DFNA5
, non-syndromic hearing impairment protein 5 homolog