Aperçu des produits pour anti-EYA4 (EYA4) Anticorps

Full name:: anti-Eyes Absent Homolog 4 (Drosophila) Anticorps (EYA4)

Chez www.anticorps-enligne.fr sont 77 Eyes Absent Homolog 4 (Drosophila) (EYA4) Anticorps de 14 de différents fournisseurs disponibles. De plus, nous expédions EYA4 Protéines (4) et et beaucoup plus de produits pour cette protéine. Un total de 90 EYA4 produits sont actuellement listés.

Synonymes:: B130023L16Rik, CMD1J, DFNA10

afficher tous les anticorps	Gène	GeneID	UniProt
	EYA4	14051
	EYA4	2070	O95677
	EYA4	292172
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Pathways pertinentes pour anti-EYA4 Anticorps

Sensory Perception of Sound

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anti-EYA4 Anticorps mieux référencés

Human Polyclonal EYA4 Primary Antibody pour ELISA - ABIN547556 : Schönberger, Wang, Shin, Kim, Depreux, Zhu, Zon, Pizard, Kim, Macrae, Mungall, Seidman, Seidman: Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss. dans Nature genetics 2005 (PubMed)

Plus d’anticorps contre EYA4 partenaires d’interaction

Mouse (Murine) Eyes Absent Homolog 4 (Drosophila) (EYA4) interaction partners

results implicate Eya4/Six1 (Montrer SIX1 Anticorps) regulates normal cardiac function via p27 (Montrer CDKN1B Anticorps)/casein kinase-2alpha/histone deacetylase 2 (Montrer HDAC2 Anticorps) and indicate that mutations within this transcriptional complex and signaling cascade lead to the development of cardiomyopathy.
constructs of the homologous region ( Eya1HR and Eya4HR) interact with Six1 (Montrer SIX1 Anticorps) prey constructs, although no interaction with Dach1 (Montrer DACH1 Anticorps) prey was demonstrable
Eya4(-/-) mice developed otitis media with effusion; anatomic studies revealed abnormal middle ear cavity and eustachian tube dysmorphology.
that Eyes absent 4 (EYA4), originally identified as a co-transcription factor, stimulates the expression of IFN-beta (Montrer IFNB1 Anticorps) and CXCL10 (Montrer CXCL10 Anticorps) in response to the undigested DNA of apoptotic cells

Human Eyes Absent Homolog 4 (Drosophila) (EYA4) interaction partners

Overexpression of EYA4 enhanced glioma cell proliferation, and EYA4 suppressed the expression of p27Kip1 (Montrer CDKN1B Anticorps) directly in these cells.
Although the clinical patient outcome of our 38 Colorectal Cancer patients was not associated with EYA4 promoter hypermethylation, the high frequency of this methylation and its high sensitivity and specificity to neoplastic cells may qualify EYA4 promoter methylation as a potential candidate screening marker in Iranian population and may help to improve early detection of CRC (Montrer CALR Anticorps).
Eyes absent homolog 4 (Drosophila) protein (EYA4) is frequently hypermethylated in esophageal squamous cell carcinoma (ESCC) and may function as a tumor suppressor gene in the development of ESCC.
identified novel EYA4 mutation can be considered responsible of the hearing loss observed in the proband and her father, while a dual molecular diagnosis was reached in the relatives co-segregating the EYA4 and the PAX3 (Montrer PAX3 Anticorps) mutations
EYA4 hypermethylation is associated with colorectal cancer.
EYA4 functions as tumor suppressor gene in pancreatic ductal adenocarcinoma via repressing beta-catenin/ID2 activation, and was an independent prognostic factor in PDAC.
Low expression of EYA4 is associated with oral cancer.
We discovered two genome-wide significant SNPs. The first was novel and near ISG20 (Montrer ISG20 Anticorps). The second was in TRIOBP (Montrer TRIOBP Anticorps), a gene previously associated with prelingual nonsyndromic hearing loss. Motivated by our TRIOBP (Montrer TRIOBP Anticorps) results, we also looked at exons in known hearing loss genes, and identified two additional SNPs, rs2877561 in ILDR1 (Montrer ILDR1 Anticorps) and rs9493672 in EYA4 (at a significance threshold adjusted for number of SNPs in those regions).
Up to now, merely 7 loci have been linked to mid-frequency hearing loss. Only four genetic mid-frequency deafness genes, namely, DFNA10 (EYA4), DFNA8 (Montrer TECTA Anticorps)/12 (TECTA (Montrer TECTA Anticorps)), DFNA13 (COL11A2 (Montrer COL11A2 Anticorps)), DFNA44 (CCDC50 (Montrer CCDC50 Anticorps)), have been reported to date. [review]
study identified EYA4 gene as targets for AML1 (Montrer RUNX1 Anticorps)-ETO (Montrer RUNX1T1 Anticorps) and indicated it as a novel tumor suppressor gene. In addition, we provided evidence that EYA4 gene might be a novel therapeutic target and a potential candidate for treating AML1 (Montrer RUNX1 Anticorps)-ETO (Montrer RUNX1T1 Anticorps)+ t (8;21) AML (Montrer RUNX1 Anticorps).

EYA4 profil antigène

Antigen Summary

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant nonsyndromic sensorineural 10 locus. Defects in this gene are also associated with dilated cardiomyopathy 1J. Three transcript variants encoding distinct isoforms have been identified for this gene.

Alternative names and synonyms associated with EYA4

EYA transcriptional coactivator and phosphatase 4 (Eya4) anticorps
EYA transcriptional coactivator and phosphatase 4 (EYA4) anticorps

B130023L16Rik anticorps
CMD1J anticorps
DFNA10 anticorps

Protein level used designations for EYA4

eyes absent homolog 4 , dJ78N10.1 (eyes absent) , eyes absent 4

GENE ID	SPECIES
14051	Mus musculus
2070	Homo sapiens
395716	Gallus gallus
483991	Canis lupus familiaris
100157256	Sus scrofa
538786	Bos taurus
292172	Rattus norvegicus

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Show all anti-Eyes Absent Homolog 4 (Drosophila) (EYA4) Anticorps with Pubmed References

Mouse (Murine) Eyes Absent Homolog 4 (Drosophila) (EYA4) interaction partners

Human Eyes Absent Homolog 4 (Drosophila) (EYA4) interaction partners

Antigen Summary

Alternative names and synonyms associated with EYA4

Protein level used designations for EYA4