Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher tous les synonymes
Sélectionnez vos espèces d'intérêt
Findings suggest that Flg mutation causes the decrease in sweating in the murine model.
Loss of epidermal AP1 (Montrer JUN Protéines) reduces filaggrin level, alters chemokine (Montrer CCL1 Protéines) expression and produces an ichthyosis (Montrer LBR Protéines)-related phenotype.
increased activity of the PI3K/AKT (Montrer AKT1 Protéines) signaling pathway in Pelo (Montrer PELO Protéines)-deficient skin might conflict with the dephosphorylation of profilaggrin and thereby affect its proper processing into filaggrin monomers and ultimately the epidermal differentiation
Filaggrin deficiency did not affect the epidermal tight junction barrier directly, but once dermatitis occurred, the skin inflammation induced TJ dysfunction
Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus.
Hypoxic treatment of primary keratinocytes induced filaggrin (Flg) gene expression in a HIF1alpha (Montrer HIF1A Protéines)- and HIF2alpha (Montrer EPAS1 Protéines)-dependent manner.
the a/a ma ft/ma ft/J mouse model can be used as an appropriate model to study early AD onset associated with profilaggrin deficiency.
Mere impairment of filaggrin degradation by loss of caspase 14 (Montrer CASP14 Protéines) does not influence the inflammatory threshold of atopic dermatitis.
Complete filaggrin deficiency led to altered barrier integrity and enhanced sensitization, which are important factors in early-phase atopic dermatitis.
The decreased expression of epidermal growth factor receptor (EGFR (Montrer EGFR Protéines)), E-cadherin (Montrer CDH1 Protéines), occludin (Montrer OCLN Protéines), and SIRT1 (Montrer SIRT1 Protéines) in the skin of Flg(ft) mice, compared with those in C57BL/6J mice, is reported.
The present study demonstrated that the downregulation of filaggrin in the epidermis by toluene is mediated by ERK1/2 and STAT3 (Montrer STAT3 Protéines)-dependent pathways.
FLG (Montrer FGFR1 Protéines) mutation was not associated with MM in the studied populations.
The results show that patients carrying filaggrin mutations had increase prevalence of Staphylococcus aureus colonization.
We suggest that SNP in FLG (Montrer FGFR1 Protéines) (rs11204981) may serve as an important predictive marker for the combined eczema plus asthma phenotype, and that the highest level of expression in heterozygous may have a protective role in developing allergy phenotype.
This study indicates an increased susceptibility to actinic keratosis in individuals with homozygous, but not heterozygous, FLG (Montrer FGFR1 Protéines) mutations and in patients with atopic dermatitis compared to psoriasis.
This study demonstrated, for the first time, that FLG (Montrer FGFR1 Protéines) expression in UCB is associated with eczema development in infancy. Moreover, our analysis provided prediction models that were capable of discriminating, to a great extent, between those who will and will not develop eczema in infancy.
In a side-to-side comparison of two different methods to determine NMF in atopic dermatitis patients: Raman microspectroscopy and stratum corneum tape stripping followed by HPLC. both methods demonstrated a concentration-depth dependence of NMF and reduced NMF levels in the carriers of filaggrin null mutations
FLG (Montrer FGFR1 Protéines) and POSTN (Montrer POSTN Protéines) expression may be downregulated and upregulated, respectively, in the esophageal mucosa of patients with active eosinophilic esophagitis, and these changes may be restored with treatment in a significant percentage of cases.
immunoreactivity for filaggrin was significantly more intense in the oral mucosa in the patients with OLP/OLL compared with healthy controls
atopic dermatitis patients without palmoplantar hyperlinearity unlikely to carry FLG (Montrer FGFR1 Protéines) mutations
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
, keratin intermediate filament-associated protein
, epidermal filaggrin
, Filaggrin (profilaggrin)