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Human Polyclonal KCNE1 Primary Antibody pour IF (p), IHC (p) - ABIN1385530
Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. dans Basic research in cardiology 2014
Human Monoclonal KCNE1 Primary Antibody pour RNAi, ELISA - ABIN561579
Wang, Zankov, Jiang, Zhang, Henderson, Tseng: [Ca2+]i elevation and oxidative stress induce KCNQ1 protein translocation from the cytosol to the cell surface and increase slow delayed rectifier (IKs) in cardiac myocytes. dans The Journal of biological chemistry 2013
TNIK (Traf2 and Nck-interacting kinase (Montrer TNIK Anticorps)) and MINK (Misshapen/NIKs-related kinase) MAP4K signalling kinases are integral components of both canonical and non-canonical pathways in Xenopus.
KCNE1/KCNQ1 (Montrer KCNQ1 Anticorps) was expressed in Xenopus oocytes with and without beta-catenin (Montrer CTNNB1 Anticorps). Confocal microscopy revealed that beta-catenin (Montrer CTNNB1 Anticorps) enhanced the KCNE1/KCNQ1 (Montrer KCNQ1 Anticorps) protein abundance in the cell membrane.
PIP(2) has a role in KCNE1 modulation of I(Ks) channels that may represent a common mechanism of auxiliary subunit modulation of many ion channels
characterize a new component of the early bioelectrical circuit: the potassium channel (Montrer KCNAB2 Anticorps) KCNQ1 (Montrer KCNQ1 Anticorps) and its accessory subunit KCNE1
phenylboronic acid (PBA) activates KCNQ1 (Montrer KCNQ1 Anticorps)/KCNE1 complexes
All the protein systems generated through these processes were refined by long Molecular Dynamics simulations. The refined models were analyzed extensively to infer data about the interaction of KCNQ1 (Montrer KCNQ1 Anticorps) channel with its accessory KCNE1 beta subunits.
In lesion samples collected from children with cardiac insufficiency, for Mink-S27 (Montrer RPS27 Anticorps), we detected significant difference in AA, CC genotype frequency and allele frequency between the observation group and the control group
SUMOylation of KCNQ1 (Montrer KCNQ1 Anticorps) is KCNE1 dependent and determines the native attributes of cardiac IKs in vivo.
Equine KV7.1 (Montrer KCNQ1 Anticorps)/KCNE1 expressed in CHO (Montrer COL11A1 Anticorps)-K1 cells exhibited electrophysiological properties that are overall similar to the human orthologs; however, a slower deactivation was found which could result in more open channels at fast rates.
The KCNE1 (rs1805127) appears to an independent risk factor for AF in the Uygur population. And the KCNE4 (Montrer KCNE4 Anticorps) (rs12621643) was an independent risk factor for AF among both Uygurs and Hans.
Western blotting analysis combined with these pharmacological data suggest that long-term insulin (Montrer INS Anticorps) treatment augments KCNQ1 (Montrer KCNQ1 Anticorps)/KCNE1 currents by increasing KCNE1 protein expression.
KCNQ1/KCNE1 channel does not require phosphatidylinositol-4,5-bisphosphate (PIP2) or phosphatidylinositol-4-phosphate for anterograde trafficking, but is heavily reliant on PIP2 for channel function once at the plasma membrane.
The genetic variant rs426496 in AQP2 (Montrer AQP2 Anticorps); rs591810 in AQP3 (Montrer AQP3 Anticorps) and rs1805127, rs1805128, and rs17173510, in KCNE1 were found in patients with Meniere's disease
Meta-analysis suggests that the G38S polymorphism in the KCNE1 gene can significantly increase the risk of atrial fibrillation in both Chinese and white individuals.
Sphingomyelin synthase 1 (Montrer SGMS1 Anticorps) positively regulates KCNQ1 (Montrer KCNQ1 Anticorps)/KCNE1 channel density in a protein kinase D (Montrer PRKD1 Anticorps)-dependent manner.
miR-1 by anti-miR-1 inhibitor oligonucleotides alleviated the downregulation of KCNE1 and KCNB2 (Montrer KCNB2 Anticorps), the shortening of AERP, and the increase in the IKs
The localization of KCNE1 in the RPE (Montrer RPE Anticorps) basal membrane, where KCNQ5 (Montrer KCNQ5 Anticorps) was previously found to be present, suggests that this beta-subunit (Montrer POLG Anticorps) may contribute to M-type K(+) channels in this membrane.
The electrophysiological effects of BACE1 (Montrer BACE Anticorps) on KCNQ1 (Montrer KCNQ1 Anticorps) reported here were independent of its enzymatic activity.
KCNE1 and KCNE3 (Montrer Kcne3 Anticorps): The yin and yang of voltage-gated K(+) channel (Montrer KCND3 Anticorps) regulation
KCNE1 and KCNE2 (Montrer KCNE2 Anticorps), auxiliary subunits of voltage-gated potassium channels, undergo sequential cleavage mediated by either alpha-secretase and presenilin(PS)/gamma-secretase or BACE1 (Montrer BACE Anticorps) and PS/gamma-secretase in cells.
In clearance studies the KCNE1 knockout mice had an increased fractional excretion of Na+, Cl-, HCO3(-) and water.
This study confirmed that KCNE1 channels are necessary for K+ secretion in developmental Saccule and Utricle in mice.
both the voltage-dependence and kinetics of gating were found to depend on the relative densities of KCNQ1 (Montrer KCNQ1 Anticorps) and KCNE1, suggesting the heart rhythm may be regulated by the relative expression of the auxiliary subunit
Findings directly implicate triggered electrical activity and spatial and temporal re-entrant mechanisms in the arrhythmogenesis observed in KCNE1 (-/-) hearts.
intestinal Cl(-) secretion is independent from KCNE1 but requires KCNQ1 (Montrer KCNQ1 Anticorps) and in mouse pancreatic acini KCNQ1 (Montrer KCNQ1 Anticorps) probably co-assembled with KCNE1 leads to a voltage-dependent K(+) current that might be of importance for electrolyte and enzyme secretion.
the spatial expression of minK-lacZ (Montrer GLB1 Anticorps) in the adult mouse heart has been shown, for the larger part, to be coincident with the conduction tissues
The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified.
potassium voltage-gated channel, Isk-related family, member 1
, voltage-gated potassium channel subunit MinK
, potassium voltage-gated channel subfamily E member 1
, IKs producing slow voltage-gated potassium channel subunit beta Mink
, cardiac delayed rectifier potassium channel protein
, delayed rectifier potassium channel subunit IsK
, minimal potassium channel
, potassium voltage-gated channel, Isk-related subfamily, member 1
, voltage gated potassiun channel accessory subunit
, potassium (K+) channel protein, slowly activating (Isk)
, potassium voltage-gated channel Shaw-related subfamily member 1
, delayed rectifier potassium channel protein
, slow delayed rectifier K+ channel
, voltage gated potassium channel accessory subunit cardiac splice