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anti-Human EPAS1 Anticorps:
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Fish Polyclonal EPAS1 Primary Antibody pour ChIP, ELISA - ABIN151051
Conrad, Freeman, Beitner-Johnson, Millhorn: EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. dans The Journal of biological chemistry 1999
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Hamster Monoclonal EPAS1 Primary Antibody pour ChIP, ELISA - ABIN151063
Bernhardt, Wiesener, Weidemann, Schmitt, Weichert, Lechler, Campean, Ong, Willam, Gretz, Eckardt: Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. dans The American journal of pathology 2007
Show all 149 Pubmed References
Hamster Monoclonal EPAS1 Primary Antibody pour ELISA, IHC - ABIN250056
Harvey, Kind, Pantaleon, Armstrong, Thompson: Oxygen-regulated gene expression in bovine blastocysts. dans Biology of reproduction 2004
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Hamster Monoclonal EPAS1 Primary Antibody pour ELISA, ICC - ABIN250055
Mekhail, Gunaratnam, Bonicalzi, Lee: HIF activation by pH-dependent nucleolar sequestration of VHL. dans Nature cell biology 2004
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Fish Polyclonal EPAS1 Primary Antibody pour ELISA, ICC - ABIN249868
Alvarez-Tejado, Naranjo-Suarez, Jiménez, Carrera, Landázuri, del Peso: Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. dans The Journal of biological chemistry 2001
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Human Monoclonal EPAS1 Primary Antibody pour IHC (fro), IHC (p) - ABIN1742588
Wiesener, Turley, Allen, Willam, Eckardt, Talks, Wood, Gatter, Harris, Pugh, Ratcliffe, Maxwell: Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. dans Blood 1998
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Human Polyclonal EPAS1 Primary Antibody pour IF (p), IHC (p) - ABIN686662
Li, Chen, Shao, Tang, Chen, Chen, Xu: Oxidative stress induces the decline of brain EPO expression in aging rats. dans Experimental gerontology 2016
Hamster Monoclonal EPAS1 Primary Antibody pour ELISA, FACS - ABIN406865
Su, Li, Cui, Ji, Geng, Chai, Ma, Bai, Yang, Wuren, Ge, Rondina: The Local HIF-2α/EPO Pathway in the Bone Marrow is Associated with Excessive Erythrocytosis and the Increase in Bone Marrow Microvessel Density in Chronic Mountain Sickness. dans High altitude medicine & biology 2015
Human Monoclonal EPAS1 Primary Antibody pour AA, ELISA - ABIN863099
Kim, Perera, Zhou, Carretero, Yeh, Heathcote, Jackson, Nikolinakos, Ospina, Naumov, Brandstetter, Weigman, Zaghlul, Hayes, Padera, Heymach, Kung, Sharpless, Kaelin, Wong: HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. dans The Journal of clinical investigation 2009
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Human Monoclonal EPAS1 Primary Antibody pour IHC (p) - ABIN2473999
Pike, Phadwal, Simon, Harris: ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia. dans Molecular biology reports 2012
HIF-2alpha plays an important role in regulating the expression of c-Myc (Montrer MYC Anticorps) in chronic hypoxia, and consequently controls the sensitivity of colon cancer cells to 5-FU treatment in this environment.
The present study identifies novel HIF-2alpha-target genes that may regulate endothelial sprouting during prolonged hypoxia.
Exogenous acetate augments Acss2 (Montrer ACSS2 Anticorps)/HIF-2 dependent cancer growth and metastasis in cell culture and mouse models
the structural model of the HIF2a-pVHL (Montrer VHL Anticorps) complex presented in this study enhances understanding of how HIF2a is captured by pVHL (Montrer VHL Anticorps). Moreover, the important contact amino acids that we identified may be useful in the development of drugs to treat HIF2a-related diseases.
Thus, we provide evidence here that HIF-2a is a critical regulator of PD-L1 (Montrer CD274 Anticorps) at both mRNA and protein levels and that HIF-2a regulates the expression of PD-L1 (Montrer CD274 Anticorps) by binding directly to the HRE-4 in the PD-L1 (Montrer CD274 Anticorps) proximal promoter.
HIF2alpha has a role and is an independent marker of the metastatic potential of bone metastatic clear cell renal cell cancer; however, unlike HIF1alpha (Montrer HIF1A Anticorps), increased HIF2alpha expression is a favorable prognostic factor
Knockdown of either HIF-1 (Montrer HIF1A Anticorps) or CREB (Montrer CREB1 Anticorps) or both in hypoxia reduced the expression of hypoxia-response elements- and CRE-mediated gene expression, diminished cell proliferation and increased caspase-3 (Montrer CASP3 Anticorps) activity. We did not detect any significant effect of the efficiently knocked down HIF-2 on any of the functions tested in vitro.
miR (Montrer MLXIP Anticorps)-558 facilitates the expression of HIF-2alpha through binding to its 5'-UTR (Montrer UTS2R Anticorps), thus promoting the tumorigenesis and aggressiveness of neuroblastoma (Montrer ARHGEF16 Anticorps)
Over-expression of HIF-2alpha induced apoptosis in HCC (Montrer FAM126A Anticorps) cells and increased the levels of pro-apoptotic proteins, Bak (Montrer BAK1 Anticorps), ZBP-89 (Montrer ZNF148 Anticorps) and PDCD4 (Montrer PDCD4 Anticorps), whereas the inhibition of HIF-2alpha expression achieved opposite results. HIF-2alpha was decreased and played an anti-tumorigenic role in hepatocellular carcinoma.
Probiotic Bifidobacterium bifidum MIMBb75 may help attenuating EPAS1 overexpression associated with intestinal inflammation.
Data suggest that chronic hypoxia enhances HIF-2alpha stability, which causes increased arginase expression and dysregulates normal vascular NO homeostasis.
Data show that Tet1 (Montrer TET1 Anticorps) modulates HIF-2alpha and HIF-1alpha (Montrer HIF1A Anticorps) through different mechanisms.
intestine HIF-2alpha regulates ceramide metabolism mainly from the salvage pathway, by positively regulating the expression of Neu3 (Montrer Neu3 Anticorps), the gene encoding neuraminidase 3 (Montrer Neu3 Anticorps). These results suggest that intestinal HIF-2alpha could be a viable target for hepatic steatosis therapy
endothelial EPAS1 has a global protective role during glomerular hypertensive injuries without influencing the hypertensive effect of angiotensin II
findings indicate that HIF-2alpha increases cancer cell growth by up-regulating YAP1 (Montrer YAP1 Anticorps) activity
Chronic activity of HIF2 in stromal progenitors impairs kidney development. Finally, these data confirm the concept that normal stroma function is essential for normal tubular differentiation.
this study shows that HIF-2alpha acts in resting macrophages as a phagocytosis suppressor implying an important relationship between the levels of HIF-2alpha and susceptibility to infection
in neurons HIF-1 (Montrer HIF1A Anticorps) and HIF-2 have redundant functions for cellular survival under ischemic conditions. By contrast, lack of anti-survival factors in Hif1a (Montrer HIF1A Anticorps)/Hif2a-deficient mice might protect from early acute neuronal cell death and neurological impairment, indicating a benefit of HIF-pathway inhibition in neurons in the very acute phase after ischemic stroke
HIF-2alpha is a novel regulator of neutrophil recruitment to colon tumors.
AQP1 (Montrer AQP1 Anticorps) deficiency delays long-term ischemia-reperfusion resolution, partly through repressing angiogenesis mediated by destabilizing HIF-2alpha.
immunostaining for HIF-1alpha (Montrer HIF1A Anticorps) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification
There was an association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with high altitude pulmonary hypertension (HAPH). There was upregulation of 26 of 27 HIF2alpha target genes in EPAS1 carriers with HAPH.
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
endothelial PAS domain protein 1
, endothelial PAS domain-containing protein 1-like
, HIF-1-alpha-like factor
, HIF-1alpha-like factor
, PAS domain-containing protein 2
, basic-helix-loop-helix-PAS protein MOP2
, class E basic helix-loop-helix protein 73
, endothelial PAS domain-containing protein 1
, hypoxia-inducible factor 2 alpha
, hypoxia-inducible factor 2-alpha
, member of PAS protein 2
, HIF-related factor
, HIF1 alpha-like factor
, HIF1alpha-like factor
, HLF (HIF1alpha-like factor)
, Hif like protein
, hypoxia inducible transcription factor 2alpha
, HIF-2 alpha
, HIF2 alpha
, hypoxia inducible factor 2, alpha subunit
, hypoxia inducible factor 2a