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Mouse (Murine) EPAS1 Kit ELISA pour Sandwich ELISA - ABIN426617
Cockle, Rajani, Zaidi, Kottke, Thompson, Diaz, Shim, Peterson, Parney, Short, Selby, Ilett, Melcher, Vile: Combination viroimmunotherapy with checkpoint inhibition to treat glioma, based on location-specific tumor profiling. dans Neuro-oncology 2016
Thus, we provide evidence here that HIF-2a is a critical regulator of PD-L1 (Montrer CD274 Kits ELISA) at both mRNA and protein levels and that HIF-2a regulates the expression of PD-L1 (Montrer CD274 Kits ELISA) by binding directly to the HRE-4 in the PD-L1 (Montrer CD274 Kits ELISA) proximal promoter.
HIF2alpha has a role and is an independent marker of the metastatic potential of bone metastatic clear cell renal cell cancer; however, unlike HIF1alpha (Montrer HIF1A Kits ELISA), increased HIF2alpha expression is a favorable prognostic factor
Knockdown of either HIF-1 (Montrer HIF1A Kits ELISA) or CREB (Montrer CREB1 Kits ELISA) or both in hypoxia reduced the expression of hypoxia-response elements- and CRE-mediated gene expression, diminished cell proliferation and increased caspase-3 (Montrer CASP3 Kits ELISA) activity. We did not detect any significant effect of the efficiently knocked down HIF-2 on any of the functions tested in vitro.
miR (Montrer MLXIP Kits ELISA)-558 facilitates the expression of HIF-2alpha through binding to its 5'-UTR (Montrer UTS2R Kits ELISA), thus promoting the tumorigenesis and aggressiveness of neuroblastoma (Montrer ARHGEF16 Kits ELISA)
Over-expression of HIF-2alpha induced apoptosis in HCC (Montrer FAM126A Kits ELISA) cells and increased the levels of pro-apoptotic proteins, Bak (Montrer BAK1 Kits ELISA), ZBP-89 (Montrer ZNF148 Kits ELISA) and PDCD4 (Montrer PDCD4 Kits ELISA), whereas the inhibition of HIF-2alpha expression achieved opposite results. HIF-2alpha was decreased and played an anti-tumorigenic role in hepatocellular carcinoma.
Probiotic Bifidobacterium bifidum MIMBb75 may help attenuating EPAS1 overexpression associated with intestinal inflammation.
Data suggest that HIF2alpha mediates hypoxia-induced cancer growth/metastasis and that EFEMP1 (Montrer FBLN3 Kits ELISA) is a downstream effector of hypoxia-induced HIF2alpha during breast tumorigenesis.
intestine HIF-2alpha regulates ceramide metabolism mainly from the salvage pathway, by positively regulating the expression of Neu3 (Montrer Neu3 Kits ELISA), the gene encoding neuraminidase 3 (Montrer Neu3 Kits ELISA). These results suggest that intestinal HIF-2alpha could be a viable target for hepatic steatosis therapy
demonstrated that MM cells are resistant to hypoxia-mediated apoptosis in vivo and in vitro, and that constitutive expression of HIF2alpha contributed to this resistance
HIF1A (Montrer HIF1A Kits ELISA) and EPAS1 potentiate hypoxia-induced upregulation of INHA (Montrer INHA Kits ELISA) expression in human term cytotrophoblasts in vitro.
Data show that Tet1 modulates HIF-2alpha and HIF-1alpha (Montrer HIF1A Kits ELISA) through different mechanisms.
endothelial EPAS1 has a global protective role during glomerular hypertensive injuries without influencing the hypertensive effect of angiotensin II
findings indicate that HIF-2alpha increases cancer cell growth by up-regulating YAP1 (Montrer YAP1 Kits ELISA) activity
Chronic activity of HIF2 in stromal progenitors impairs kidney development. Finally, these data confirm the concept that normal stroma function is essential for normal tubular differentiation.
this study shows that HIF-2alpha acts in resting macrophages as a phagocytosis suppressor implying an important relationship between the levels of HIF-2alpha and susceptibility to infection
in neurons HIF-1 (Montrer HIF1A Kits ELISA) and HIF-2 have redundant functions for cellular survival under ischemic conditions. By contrast, lack of anti-survival factors in Hif1a (Montrer HIF1A Kits ELISA)/Hif2a-deficient mice might protect from early acute neuronal cell death and neurological impairment, indicating a benefit of HIF-pathway inhibition in neurons in the very acute phase after ischemic stroke
HIF-2alpha is a novel regulator of neutrophil recruitment to colon tumors.
AQP1 (Montrer AQP1 Kits ELISA) deficiency delays long-term ischemia-reperfusion resolution, partly through repressing angiogenesis mediated by destabilizing HIF-2alpha.
HIF1alpha (Montrer HIF1A Kits ELISA) and HIF2alpha are dispensable for muscle stem cell function under normoxia but are required for maintaining satellite cell self-renewal in hypoxic environments.
immunostaining for HIF-1alpha (Montrer HIF1A Kits ELISA) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification
There was an association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with high altitude pulmonary hypertension (HAPH). There was upregulation of 26 of 27 HIF2alpha target genes in EPAS1 carriers with HAPH.
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
endothelial PAS domain protein 1
, endothelial PAS domain-containing protein 1-like
, HIF-1-alpha-like factor
, HIF-1alpha-like factor
, PAS domain-containing protein 2
, basic-helix-loop-helix-PAS protein MOP2
, class E basic helix-loop-helix protein 73
, endothelial PAS domain-containing protein 1
, hypoxia-inducible factor 2 alpha
, hypoxia-inducible factor 2-alpha
, member of PAS protein 2
, HIF-related factor
, HIF1 alpha-like factor
, HIF1alpha-like factor
, HLF (HIF1alpha-like factor)
, Hif like protein
, hypoxia inducible transcription factor 2alpha
, HIF-2 alpha
, HIF2 alpha
, hypoxia inducible factor 2, alpha subunit
, hypoxia inducible factor 2a