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Mouse (Murine) EPAS1 Kit ELISA pour Sandwich ELISA - ABIN426617
Cockle, Rajani, Zaidi, Kottke, Thompson, Diaz, Shim, Peterson, Parney, Short, Selby, Ilett, Melcher, Vile: Combination viroimmunotherapy with checkpoint inhibition to treat glioma, based on location-specific tumor profiling. dans Neuro-oncology 2016
positive and bilateral HIF2-EGFR (Montrer EGFR Kits ELISA) regulatory crosstalk promotes antiestrogen resistance in estrogen receptor alpha (Montrer ESR1 Kits ELISA)-positive breast cancer
NAP peptide prevents outer blood retinal barrier breakdown by reducing HIF1alpha (Montrer HIF1A Kits ELISA)/HIF2alpha, VEGF (Montrer VEGFA Kits ELISA)/VEGFRs, and increasing HIF3alpha expression Moreover it is able to reduce the percentage of apoptotic cells by modulating the expression of two death related genes, BAX (Montrer BAX Kits ELISA) and Bcl2 (Montrer BCL2 Kits ELISA).
Data identify a previously unrecognized cellular process associated with hypoxia, and suggests that in vivo tumour hypoxia determines copper isotope fractionation in hepatocellular carcinoma and demonstrate that this effect of hypoxia is pH, HIF-1 (Montrer HIF1A Kits ELISA) and -2 independent.
findings suggest the HIF-2alpha pathway predominates over HIF-1alpha (Montrer HIF1A Kits ELISA) signalling in neuronal-like cells following acute hypoxia
these findings demonstrated that HIF-2alpha in vselMSCs cooperated with Oct4 (Montrer POU5F1 Kits ELISA) in survival and function. The identification of the cooperation between HIF-2alpha and Oct4 (Montrer POU5F1 Kits ELISA) will lead to deeper characterization of the downstream targets of this interaction in vselMSCs and will have novel pathophysiological implications for the repair of infarcted myocardium.
findings indicate that HIF-2alpha increases cancer cell growth by up-regulating YAP1 (Montrer YAP1 Kits ELISA) activity
Findings show that hypoxia inducible factor 1 alpha subunit (HIF-1alpha (Montrer HIF1A Kits ELISA)) is phylogenetically conserved among most metazoans, whereas HIF-2alpha protein appeared later.
proteomic experiments on Normoxic Neuroblastoma (Montrer ARHGEF16 Kits ELISA) cells to investigate HIF-2alpha downstream-regulated proteins or pathways
HIF1A (Montrer HIF1A Kits ELISA) and HIF2A contribute to cancer stem cells survival but play different roles -HIF1A (Montrer HIF1A Kits ELISA) being more responsible for survival functions and HIF2A for self-renewal [review].
The negative feedback modulation between LncRNA-SARCC/AR complex and HIF-2alpha signaling may then lead to differentially modulated RCC (Montrer XRCC1 Kits ELISA) progression in a VHL (Montrer VHL Kits ELISA)-dependent manner. Together, these results may provide us a new therapeutic approach via targeting this newly identified signal from LncRNA-SARCC to AR-mediated HIF-2alpha/C-MYC (Montrer MYC Kits ELISA) signals against RCC (Montrer XRCC1 Kits ELISA) progression.
Chronic activity of HIF2 in stromal progenitors impairs kidney development. Finally, these data confirm the concept that normal stroma function is essential for normal tubular differentiation.
this study shows that HIF-2alpha acts in resting macrophages as a phagocytosis suppressor implying an important relationship between the levels of HIF-2alpha and susceptibility to infection
in neurons HIF-1 (Montrer HIF1A Kits ELISA) and HIF-2 have redundant functions for cellular survival under ischemic conditions. By contrast, lack of anti-survival factors in Hif1a (Montrer HIF1A Kits ELISA)/Hif2a-deficient mice might protect from early acute neuronal cell death and neurological impairment, indicating a benefit of HIF-pathway inhibition in neurons in the very acute phase after ischemic stroke
HIF-2alpha is a novel regulator of neutrophil recruitment to colon tumors.
AQP1 (Montrer AQP1 Kits ELISA) deficiency delays long-term ischemia-reperfusion resolution, partly through repressing angiogenesis mediated by destabilizing HIF-2alpha.
HIF1alpha (Montrer HIF1A Kits ELISA) and HIF2alpha are dispensable for muscle stem cell function under normoxia but are required for maintaining satellite cell self-renewal in hypoxic environments.
eIF3e (Montrer EIF3E Kits ELISA) is an angiogenesis suppressor. Silencing of eIF3e (Montrer EIF3E Kits ELISA) promotes blood perfusion recovery after limb ischemia through stabilization of hypoxia-inducible factor 2alpha activity.
The regulatory connection between HIF-2alpha and VEGFR-1 (Montrer FLT1 Kits ELISA), VEGFR-2 (Montrer KDR Kits ELISA) and MMP2 (Montrer MMP2 Kits ELISA).
HIF2alpha is essential for the acute postprandial regulation of hepatic glucagon (Montrer GCG Kits ELISA) signaling.
immunostaining for HIF-1alpha (Montrer HIF1A Kits ELISA) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification
There was an association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with high altitude pulmonary hypertension (HAPH). There was upregulation of 26 of 27 HIF2alpha target genes in EPAS1 carriers with HAPH.
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
endothelial PAS domain protein 1
, endothelial PAS domain-containing protein 1-like
, HIF-1-alpha-like factor
, HIF-1alpha-like factor
, PAS domain-containing protein 2
, basic-helix-loop-helix-PAS protein MOP2
, class E basic helix-loop-helix protein 73
, endothelial PAS domain-containing protein 1
, hypoxia-inducible factor 2 alpha
, hypoxia-inducible factor 2-alpha
, member of PAS protein 2
, HIF-related factor
, HIF1 alpha-like factor
, HIF1alpha-like factor
, HLF (HIF1alpha-like factor)
, Hif like protein
, hypoxia inducible transcription factor 2alpha
, HIF-2 alpha
, HIF2 alpha
, hypoxia inducible factor 2, alpha subunit
, hypoxia inducible factor 2a