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Human Monoclonal MAP3K13 Primary Antibody pour WB - ABIN1882198
Ikeda, Hasegawa, Masaki, Moriguchi, Nishida, Kozutsumi, Oka, Kawasaki: Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. dans Journal of biochemistry 2001
Show all 5 Pubmed References
Data indicate that miR (Montrer MLXIP Anticorps)-206's effect on Myc (Montrer MYC Anticorps) was mediated through MAP3K13.
LZK cooperates with DLK (Montrer DAPK3 Anticorps) to promote retinal ganglion cell death in response to axon injury.
Chromosomal localization studies involving FISH mapping demonstrated that the human LZK gene is located at 3q27.
By gain- and loss-of-function analyses in neuronal cultures, the authors identify LZK as a novel positive regulator of axon growth.
Scaffold protein (Montrer HOMER1 Anticorps) POSH (Montrer SH3RF1 Anticorps), in association with Shroom3 (Montrer SHROOM3 Anticorps) and mixed lineage kinase LZK, relays axon outgrowth inhibition downstream of NogoA (Montrer RTN4 Anticorps) and PirB (Montrer LILRB3 Anticorps) proteins.
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway.
leucine zipper-bearing kinase
, mitogen-activated protein kinase kinase kinase 13
, mitogen activated protein kinase kinase kinase 13 type A
, mitogen-activated protein kinase kinase kinase 13-A
, mixed lineage kinase
, mitogen activated protein kinase kinase kinase 13