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anti-Human GLI3 Anticorps:
anti-Rat (Rattus) GLI3 Anticorps:
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Dog (Canine) Polyclonal GLI3 Primary Antibody pour ELISA - ABIN251265
Haycraft, Banizs, Aydin-Son, Zhang, Michaud, Yoder: Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. dans PLoS genetics 2005
Human Polyclonal GLI3 Primary Antibody pour ICC, IF - ABIN4314296
Kanda, Mitsuyasu, Nakao, Kawano, Goto, Matsubara, Nakamura: Anti-apoptotic role of the sonic hedgehog signaling pathway in the proliferation of ameloblastoma. dans International journal of oncology 2013
Human Polyclonal GLI3 Primary Antibody pour ICC, IF - ABIN4314300
Jackson, Smith, Amarsaikhan, Han, Neil, Boi, Vrabel, Tolosa, Almada, Fernandez-Zapico, Elsawa: Modulation of the IL-6 Receptor α Underlies GLI2-Mediated Regulation of Ig Secretion in Waldenström Macroglobulinemia Cells. dans Journal of immunology (Baltimore, Md. : 1950) 2015
Our preliminary results identified risk variants of GLI3 that are associated with NSCL (Montrer NHLH1 Anticorps)/P susceptibility in a Chinese population. In particular, rs3801161 and its haplotypes rs3801161-rs7785287 displayed significant association with NSCL (Montrer NHLH1 Anticorps)/P and survived Bonferroni correction for multiple comparisons.
A novel GLI3 missense variant in a family that caused a spectrum of digital anomalies. All affected individuals that were tested harbored a c.1826G>A (p.(Cys609Tyr)) variant in GLI3. Functional studies of the murine p.Cys609Tyr GLI3 showed that the mutant protein is not efficiently processed to GLI3R, resulting in a full-length protein with basal transcriptional activity and submaximal pathway activation.
Hedgehog (Montrer SHH Anticorps) pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI (Montrer GLI1 Anticorps)-mediated activation of KIT expression.
The c.480dupC of the GLI3 gene probably underlies the synpolydactyly in this family.
Methylation at K436 and K595 respectively by Set7 (Montrer SETD7 Anticorps) increases the stability and DNA binding ability of Gli3, resulting in an enhancement of Shh (Montrer SHH Anticorps) signaling activation.
Data suggest that negative feedback mediated by GLI3 (GLI (Montrer GLI1 Anticorps)-Kruppel family member) acts to finely tune SHH (sonic hedgehog (Montrer SHH Anticorps)) signaling. During medulloblastoma (MB) formation, nerve tissue cells appear to express nestin (Montrer NES Anticorps) which hyperactivates SHH (Montrer SHH Anticorps) signaling by abolishing negative feedback by GLI3. Restoration of intrinsic negative feedback by repressing nestin (Montrer NES Anticorps) expression represents a promising approach to treat MB. [REVIEW]
the first report of the assessment of the frequency of GLI3/SHH (Montrer SHH Anticorps)/preZRS/ZRS in Chinese polydactyly patients to show any higher possibility of mutations or variants for the 4 genes or sequences in China
Gli3 and Teashirt3 (Montrer ZNF537 Anticorps) might play an important role in the normal development of the ureter.
a novel GLI3 mutation c.714T>A (p.Y238*) was identified in a Chinese family with pre-axial polydactyly. Our results broadened the phenotypic spectrum of GLI3 mutations and demonstrated the feasibility of WES in clinical application of molecular diagnosis.
we describe an ~5 kb deletion within the SHH (Montrer SHH Anticorps) repressor GLI3 in two patients with bilateral tibial hemimelia. This deletion results in a truncated GLI3 protein that lacks a DNA-binding domain and cannot repress hedgehog (Montrer SHH Anticorps) signaling.
5'Hoxd genes and Gli3 are part of an interdigital signalling centre that sets net Bmp signalling levels from different interdigits to coordinately regulate phalanx and joint formation.
Together, our results show that SuFu (Montrer SUFUH Anticorps) promotes cerebellar radial precursor differentiation to neurons. SuFu (Montrer SUFUH Anticorps) function is mediated in part by GLI3R and down-regulation of Fgf15 expression.
Gli3 is a suppressor of stem cell proliferation that affects the number and function of mature taste cells, especially Tas1r3 (Montrer TAS1R3 Anticorps)+ cells, in adult posterior tongue.
Gli3 activity in mouse thymic epithelial cells (TECs) promotes positive selection and differentiation from CD4 (Montrer CD4 Anticorps)(+) CD8 (Montrer CD8A Anticorps)(+) to CD4 (Montrer CD4 Anticorps)(+) CD8 (Montrer CD8A Anticorps)(-) single-positive (SP4 (Montrer SP4 Anticorps)) cells in the fetal thymus and Gli3 represses Shh (Montrer SHH Anticorps) constitutive deletion of Gli3, and conditional deletion of Gli3 from TECs, reduced differentiation to SP4 (Montrer SP4 Anticorps), whereas conditional deletion of Gli3 from thymocytes did not.
loss of Spop (Montrer SPOP Anticorps), but not Spopl (Montrer SPOPL Anticorps), disrupts chondrocyte hypertrophy and osteoblast differentiation in the mouse, suggesting the requirement for Spop (Montrer SPOP Anticorps)-mediated protein degradation in mouse skeletal development; overexpressed Spop (Montrer SPOP Anticorps) targets both Gli3FL and Gli3R for ubiquitination and degradation and Spop (Montrer SPOP Anticorps) is an important positive regulator of Ihh (Montrer IHH Anticorps) signaling and skeletal development
mutual interactions between Gli3, Wnt8b (Montrer WNT8B Anticorps), and Fgf17 (Montrer FGF17 Anticorps) are crucial elements of the balance between these factors thereby conferring robustness to the patterning process
Results demonstrate a negative role of Spop (Montrer SPOP Anticorps) in the level and activity of Gli3, Shh (Montrer SHH Anticorps) signaling and ventral spinal cord patterning.
Gli2 (Montrer GLI2 Anticorps) and Gli3 are dephosphorylated and activated in cilia and that impaired Gli2 (Montrer GLI2 Anticorps) and Gli3 processing in Ta3 (Montrer HSP90B1 Anticorps) mutant is at least in part due to a decrease in Gli2 (Montrer GLI2 Anticorps) and Gli3 phosphorylation.
These results suggest that Tctn1 (Montrer TCTN1 Anticorps), Tctn2 (Montrer TCTN2 Anticorps), and Tctn3 (Montrer TCTN3 Anticorps) are functionally divergent with respect to their role in ciliogenesis and Hedgehog (Montrer SHH Anticorps) signaling but conserved in neural tube patterning and Gli3 processing.
Results indicate that the transcription factor Gli3 (Gli3)-mutant fetal liver (FL) had increased sonic hedgehog (Shh (Montrer SHH Anticorps)) signaling resulting in decreased B cell development.
Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog (Montrer SHH Anticorps) signaling. In the eye, Gli3 is also required for proper ath5 (Montrer ATOH7 Anticorps) expression and the differentiation of retinal ganglion cells.
The results provided evidence that polymorphisms in the GLI3 gene are associated with growth traits, and may be used for marker-assisted selection in beef cattle breeding program.
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B.
GLI-Kruppel family member GLI3
, glioma-associated oncogene family zinc finger 3
, oncogene GLI3
, transcriptional activator GLI3
, zinc finger protein GLI3
, GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome)
, GLI3 full length protein
, neural specific DNA binding protein
, neural-specific DNA-binding protein xGLI3
, GLI-Kruppel family member 3
, GLI3 form of 190 kDa
, anterior digit pattern deformity
, extra toes
, polydactyly Nagoya
, zinc finger transcription factor Gli3
, GLI family zinc finger 3