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anti-Mouse (Murine) Sonic Hedgehog Anticorps:
anti-Human Sonic Hedgehog Anticorps:
anti-Rat (Rattus) Sonic Hedgehog Anticorps:
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Human Polyclonal Sonic Hedgehog Primary Antibody pour IF (p), IHC (p) - ABIN731108
Weiss, Guo, Shan, Shi, Romano, Sinha, Cantley, Guo: Brg1 determines urothelial cell fate during ureter development. dans Journal of the American Society of Nephrology : JASN 2013
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Zebrafish (Danio rerio) Polyclonal Sonic Hedgehog Primary Antibody pour WB - ABIN1882186
Ekker, Ungar, Greenstein, von Kessler, Porter, Moon, Beachy: Patterning activities of vertebrate hedgehog proteins in the developing eye and brain. dans Current biology : CB 1995
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Human Monoclonal Sonic Hedgehog Primary Antibody pour ELISA, WB - ABIN969395
Dierker, Dreier, Migone, Hamer, Grobe: Heparan sulfate and transglutaminase activity are required for the formation of covalently cross-linked hedgehog oligomers. dans The Journal of biological chemistry 2009
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Human Monoclonal Sonic Hedgehog Primary Antibody pour ELISA, WB - ABIN967021
Lee, Lee, Jung, Park, Park, Hahm: Late reactivation of sonic hedgehog by Helicobacter pylori results in population of gastric epithelial cells that are resistant to apoptosis: implication for gastric carcinogenesis. dans Cancer letters 2010
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Human Monoclonal Sonic Hedgehog Primary Antibody pour FACS - ABIN4897996
Blotta, Jakubikova, Calimeri, Roccaro, Amodio, Azab, Foresta, Mitsiades, Rossi, Todoerti, Molica, Morabito, Neri, Tagliaferri, Tassone, Anderson, Munshi: Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma. dans Blood 2012
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Human Monoclonal Sonic Hedgehog Primary Antibody pour ELISA, FACS - ABIN4355158
Valverde, Pereira, Dias, Guimarães, Ramos, Santos, Gurgel Rocha: Macrophages and endothelial cells orchestrate tumor-associated angiogenesis in oral cancer via hedgehog pathway activation. dans Tumour biology 2016
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Chicken Polyclonal Sonic Hedgehog Primary Antibody pour IHC, IHC (p) - ABIN4893080
Lozito, Tuan: Lizard tail skeletal regeneration combines aspects of fracture healing and blastema-based regeneration. dans Development (Cambridge, England) 2016
Human Monoclonal Sonic Hedgehog Primary Antibody pour FACS, IHC - ABIN969567
Kameda, Nakamura, Tanaka, Yamasaki, Kubo, Tanaka, Onishi, Katano: Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ERalpha-positive gastric cancer. dans British journal of cancer 2010
Human Polyclonal Sonic Hedgehog Primary Antibody pour ICC, IF - ABIN4355160
Palacio-Mancheno, Evashwick-Rogler, Laudier, Purmessur, Iatridis: Hyperosmolarity induces notochordal cell differentiation with aquaporin3 upregulation and reduced N-cadherin expression. dans Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1970
data illustrate that persistent Hh signaling in the palatal epithelium contributes to the etiology and pathogenesis of submucous cleft palate through its interaction with a p63 (Montrer CKAP4 Anticorps)/Irf6 (Montrer IRF6 Anticorps)-dependent biological regulatory loop and through a p63 (Montrer CKAP4 Anticorps)-induced cell adhesion network.
SOX2 (Montrer SOX2 Anticorps) functions downstream of HH signaling to regulate lingual epithelium homeostasis.
High SHH expression is associated with medulloblastoma formation.
Identify SMO-dependent Shh signalling as a specific process for the activation of adventitial fibroblasts and the subsequent proliferation of smooth muscle cells and neointima formation.
In the mutant Hammer toe (Hm) genome, a 150-kb noncoding DNA fragment from chromosome 14 is inserted into the region upstream of the Sonic hedgehog (Shh) promoter in chromosome 5. Two different regions are necessary for the syndactyly phenotype of Hm.
Data show that Sonic hedgehog (Shh), which encodes a secreted protein signal, is expressed in the sensory neurons, and that experimental ablation of neuronal Shh expression causes loss of taste receptor cells (TRCs).
Here by inducing expression of constitutively active Smoothened (SmoM2) or Gli2 (Montrer GLI2 Anticorps) (DeltaNGli2) in the adipocyte lineage of postnatal mice, the authors show that targeted activation of Hedgehog signaling suppresses high-fat-diet-induced obesity and improves whole-body glucose tolerance and insulin (Montrer INS Anticorps) sensitivity.
These data suggest a potential novel mechanism in which alterations in SHH variance during evolution may have driven changes in limb patterning and digit length.
Epithelial-mesenchymal transition programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling.
the knockdown of Ihh (Montrer IHH Anticorps) suppressed osteoblast growth and differentiation via a mechanism which may be associated with the TGF-beta (Montrer TGFB1 Anticorps)/Smad (Montrer SMAD1 Anticorps) and OPG/RANKL (Montrer TNFSF11 Anticorps) signaling pathways.
Protease nexin-1 (Montrer SERPINE2 Anticorps) prevents growth of human B cell lymphoma via inhibition of sonic hedgehog signaling.
SHH-related signaling pathway affects antineoplastic drug resistance in cultured glioma cells.
SHH is expressed in cilia in the airway epithelial cells.SHH may mediate noncanonical hedgehog signaling through motile cilia to dampen respiratory defenses.
High SHH expression is associated with radioresistance in esophageal adenocarcinoma.
In conclusion, our data suggest that overexpression of the Hedgehog components SHH, GLI2 (Montrer GLI2 Anticorps) and FOXA2 (Montrer FOXA2 Anticorps) might be used as markers of an aggressive hemangioma.
These findings showed the upexpression of sonic hedgehog and vascular endothelial growth factor (Montrer VEGF Anticorps) with co-localization in varicocele veins which imply that the reducing hypoxia or using sonic hedgehog antagonists may be helpful for this vascular disease.
Shh and Gli1 (Montrer GLI1 Anticorps) expression were associated with lymph node metastasis, TNM (Montrer ODZ1 Anticorps) stage and tumor recurrence, suggesting Shh and Gli1 (Montrer GLI1 Anticorps) protein could become the valuable biomarker in evaluating the lymph node metastasis in oral squamous cell carcinoma.
Case Report: medullablastoma with activated SHH expression.
SHH-dependent E-ligase Midline1 (Montrer MID1 Anticorps) regulates ubiquitin-mediated proteasomal degradation of Pax6 (Montrer PAX6 Anticorps) during visual system development.
Data indicate that sonic hedgehog is expressed exclusively in the notochord but not in the spinal cord of the regenerate.
Dzip1 (Montrer DZIP1 Anticorps)-dependent stabilization of Spop (Montrer SPOP Anticorps)/HIB is evolutionarily conserved and essential for proper regulation of Gli (Montrer GLI1 Anticorps)/Ci proteins in the Hh pathway.
Notch (Montrer NOTCH1 Anticorps) signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh expression in the midline.
These results indicate that electrical activity and second-messenger signaling mediate Shh action in embryonic spinal neurons.
Connective tissue-specific expression of BMP-4 (Montrer BMP4 Anticorps) mRNA is up-regulated by sonic hedgehog.
In an examination of signaling pathways in developing Xenopus lung, shh but not ihh (Montrer IHH Anticorps) was expressed in the very anterior part of early lung epithelium.
Data propose that Shh serves as a ventral optic tract repellent that helps to define the caudal (Montrer CAD Anticorps) boundary for retinal axons in the diencephalon, and that this signaling is also required for initial target recognition at the optic tectum.
The forebrain of Xenopus revealed a largely conserved pattern of Shh expression among tetrapods.
Hedgehog regulates superficial slow muscle fibres in Xenopus and tetrapod trunk myogenesis
study shows evolutionary alteration of a Ptch1 (Montrer PTCH1 Anticorps) cis (Montrer CISH Anticorps)-regulatory module, which no longer responds to graded SHH signalling during bovine handplate development
Mutation of hmgcs1 (Montrer HMGCS1 Anticorps) had no effect on Shh signaling at 2 and 3 days post fertilization (dpf), but did result in a decrease in the expression of gli1 (Montrer GLI1 Anticorps), a known Shh target gene, at 4 dpf, after morphological deficits in craniofacial development and chondrocyte differentiation were observed in hmgcs1 (Montrer HMGCS1 Anticorps) mutants.
Shha/Smo is functionally dedicated to ray branching during fin regeneration.
Shh and Rx3 govern formation of a distinct progenitor domain that elaborates patterning through its anisotropic growth and differentiation.
Time-lapse imaging revealed that knockdown of miR (Montrer MYLIP Anticorps)-219 function accelerates the growth of primary cilia, revealing a possible mechanistic link between miR (Montrer MYLIP Anticorps)-219-mediated regulation of apical Par (Montrer AFG3L2 Anticorps) proteins and Shh signaling.
Shh is not essential for the early activation of has2 (Montrer HAS2 Anticorps), but supports proper chondrogenic differentiation.
Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina.
Hedgehog signaling has a role in dental papilla formation and tooth size during zebrafish odontogenesis
Data indicate that the transgenic lines report Hedgehog pathway state in individual cells and with high sensitivity.
We further demonstrate that the elevated Hedgehog signaling in Sox11 (Montrer SOX11 Anticorps)-deficient zebrafish was caused by a large increase in shha transcription; indeed, suppressing Shha expression rescued the ocular phenotypes of sox11 (Montrer SOX11 Anticorps) morphants.
Pax6 (Montrer PAX6 Anticorps) has an evolutionarily conserved function in establishing the temporospatial expression of Shh in the mid-diencephalic organizer in vertebrates.
This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved\; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.
sonic hedgehog protein
, sonic hedgehog
, hemimelic extra toes
, short digits
, sonic hedgehog homolog
, sonic hedgehog protein A