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Human BRAF Protein expressed in HEK-293 Cells - ABIN2715104
Arnoux, Fina, Lambert, Balandraud, Martin, Ouafik, Kanaan, Roudier, Auger: Newly Identified BRAF Mutation in Rheumatoid Arthritis. dans Arthritis & rheumatology (Hoboken, N.J.) 2016
The B-Raf (Montrer SNRPE Protéines) inhibitor PLX4032 induces DR5 (Montrer TNFRSF10B Protéines) upregulation exclusively in Ras-mutant cancer cells; this effect is dependent on Ras/c-Raf (Montrer RAF1 Protéines)/MEK (Montrer MAP2K1 Protéines)/ERK (Montrer EPHB2 Protéines) signaling activation.
RNA sequencing identified in both an AKAP9-BRAF gene fusion
a new somatic BRAF splicing mutation, was identified.
RAS-ERK (Montrer EPHB2 Protéines) signaling in BRAF mutant melanomas is critical for regulating active chromatin state and recruitment of RNA polymerase II at mutant TERT (Montrer TERT Protéines) promoters. Our study provides evidence that the mutant TERT (Montrer TERT Protéines) promoter is a key substrate downstream of the RAS-ERK (Montrer EPHB2 Protéines) pathway.
the presence of the BRAF (V600E) mutation may be negatively correlated with partial aggressive clinicopathological features of pediatric papillary thyroid cancer (PTC (Montrer F9 Protéines)).
Vemurafenib, inhibiting BRAF signaling, shifted the balance of activatory and inhibitory NK ligands on melanoma cells and displayed immunoregulatory effects on NK-cell functional activities
We have found a higher incidence of axLN metastases in BRAF mutated NSCLC patients than described in non-BRAF mutated NSCLC patients. Examination of the axilla should be a routine part of physical examination in this genetically distinct subgroup of lung cancer patients.
Braf mutations served as biomarkers for response to anti-EGFR (Montrer EGFR Protéines) monoclonal antibodies in colorectal cancer.[review]
BRAF mutation, rather than KRAS, was a significant prognostic factor in Korean colorectal cancer patients at both early and advanced stages.
The lack of KRAS, NRAS (Montrer NRAS Protéines), BRAF, and PIK3CA (Montrer PIK3CA Protéines) mutation in our study may suggest that a subset of eyelid sebaceous carcinomas is unlike that of eyelid sebaceous carcinomas of western countries.
BRAF alternative splicing is differentially regulated in vertebrates. Exon 9b is present in all vertebrates, including Xenopus, but exon 8b is present only in eutherians.
Gene expression studies nominated TWIST2 (Montrer TWIST2 Protéines) as a key effector downstream of BRAF.
BRAF alternative splicing is differentially regulated in vertebrates. Exon 9b is present in all vertebrates, including Danio rerio, but exon 8b is present only in eutherians.
BRAF activation is sufficient for f-nevus formation, and is among the primary events in melanoma development.
BRAF alternative splicing is differentially regulated in rodent and primates. Exon 9b is present in vertebrates but exon 8b is present only in eutherians.
mosaic expression of BRAF(V600E) in mouse erythro-myeloid progenitors results in clonal expansion of tissue-resident macrophages and a severe late-onset neurodegenerative disorder
CDX2 (Montrer CDX2 Protéines)(Null)/BRAF(V600E) expression in adult mouse intestinal epithelium led to serrated morphology tumors (including carcinomas) and BRAF(V600E) potently interacted with CDX2 (Montrer CDX2 Protéines) silencing to alter gene expression. Like human serrated lesions, CDX2 (Montrer CDX2 Protéines)(Null)/BRAF(V600E)-mutant epithelium expressed gastric markers.
expression of an endogenous Braf(D631A) kinase-inactive isoform in mice (corresponding to the human BRAF(D594A) mutation) triggers lung adenocarcinoma in vivo, indicating that BRAF-inactivating mutations are initiating events in lung oncogenesis
TTM (Montrer SLITRK1 Protéines) reduces copper levels and MAPK (Montrer MAPK1 Protéines) signaling, thereby inhibiting BRAF(V600E)-driven melanoma tumor growth.
BRAF and ROKalpha (Montrer ROCK2 Protéines) form independent RAF1 (Montrer RAF1 Protéines) complexes in embryonic fibroblasts (MEFs) treated with epidermal growth factor (EGF (Montrer EGF Protéines)).
Braf(V600E) expression, coupled with simultaneous p53 (Montrer TP53 Protéines) ablation, permits bypass of senescence and progression to lung adenocarcinoma.
These results provide support for the role of BRAF(V600E) in metastasis.
Mechanistically, BRAF and RAF1 (Montrer RAF1 Protéines) operate independently to balance MAPK (Montrer MAPK1 Protéines) signaling: BRAF promotes ERK (Montrer EPHB2 Protéines) activation, while RAF1 (Montrer RAF1 Protéines) dims stress kinase activation.
Mass spectrometry based screening for potential interaction partners revealed that BRAF interacts and phosphorylates PAX3 (Montrer PAX3 Protéines).
Using a conditional allele for Braf(V600E) , a mutation observed in clinical cases of GIST, authors observed that Braf(V600E) activation was sufficient to drive ICC hyperplasia but not GIST tumorigenesis.
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.
94 kDa B-raf protein
, B-Raf proto-oncogene serine/threonine-protein kinase (p94)
, murine sarcoma viral (v-raf) oncogene homolog B1
, proto-oncogene B-Raf
, serine/threonine-protein kinase B-raf
, v-raf murine sarcoma viral oncogene homolog B1
, B-Raf proto-oncogene serine/threonine-protein kinase
, proto-oncogene c-Rmil
, rmil serine/threonine-protein kinase
, serine/threonine kinase
, serine/threonine-protein kinase Rmil
, serine/threonine protein kinase BRAF
, serine/threonine-protein kinase B-raf-like
, B-raf protein