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Human Cortactin Protein expressed in HEK-293 Cells - ABIN2712518
Labrador-Horrillo, Martínez, Selva-OCallaghan, Trallero-Araguás, Grau-Junyent, Vilardell-Tarrés, Juarez: Identification of a novel myositis-associated antibody directed against cortactin. dans Autoimmunity reviews 2014
Show all 3 Pubmed References
These findings suggest that the patterning of podosomes into a sealing zone involves the dynamic interaction between cofilin (Montrer CFL1 Protéines), CTTN, and the microtubule + ends.
AMPK (Montrer PRKAA1 Protéines) phosphorylation of cortactin followed by SIRT1 (Montrer SIRT1 Protéines) deacetylation modulates the interaction of cortactin and cortical-actin in response to shear stress. Functionally, this AMPK (Montrer PRKAA1 Protéines)/SIRT1 (Montrer SIRT1 Protéines) coregulated cortactin-F-actin dynamics is required for endothelial nitric oxide synthase (Montrer NOS3 Protéines) subcellular translocation/activation and is atheroprotective.
Cortactin may have an important role in the development of oral tumors in mice
findings reveal that Keap1 (Montrer KEAP1 Protéines) regulates cell migration by affecting the subcellular localization and activity of cortactin independently of its role in oxidant stress responses.
association of cortactin with Pfn-1 (Montrer PFN1 Protéines) is regulated by c-Abl (Montrer ABL1 Protéines)-mediated cortactin phosphorylation
Cell proliferation, migration and invasion were inhibited by genetic knockdown of EMS1.
our findings suggest that after GnRHa activation, src activity leads to tyrosine phosphorylation of cortactin, which facilitates its association with Arp3 to engage the actin cytoskeleton.
GIT1-cortactin association through GIT1-Spa (Montrer FASL Protéines) homology domain is required for cortactin localization to the leading edge and is essential for endothelial cell directional migration and tumor angiogenesis.
Data indicate that cortactin as an Src (Montrer SRC Protéines)-dependent interacting partner of EB1 (Montrer MAPRE1 Protéines).
Introduction of three 4-R-hydroxyproline residues stabilizes the SH3m-cortactin binding of HPK1 (Montrer MAP4K1 Protéines) peptide.
These findings suggest that this common cortactin variant may functionally contribute to ALI predisposition by impeding endothelial wound healing.
Overall, the authors find that p27 (Montrer PAK2 Protéines) directly promotes cell invasion by facilitating invadopodia turnover via the Rac1/PAK1 (Montrer PAK1 Protéines)/Cortactin pathway.
Tyrosine dephosphorylation of the cytoskeletal scaffold, cortactin, recruits the RhoA (Montrer RHOA Protéines) antagonist SRGAP1 (Montrer SRGAP1 Protéines) to relax adherens junctions in response to HGF (Montrer HGF Protéines).
cortactin binds to E-cadherin (Montrer CDH1 Protéines), and that a posttranslational modification of cortactin, RhoA (Montrer RHOA Protéines)-induced phosphorylation by protein kinase D1 (PKD1; also known as PRKD1 (Montrer PRKD1 Protéines)) at S298, impairs adherens junction assembly and supports their dissolution.
Unique role for PBF (Montrer PTTG1IP Protéines) in regulating CTTN function to promote endocrine cell invasion and migration.
These data suggest a model in which cortactin promotes exosome secretion by stabilizing cortical actin-rich multivesicular late endosome docking sites.
Cortactin may have an important role in the development of oral tumors in human
a dynamic TIP150 (Montrer KIAA0774 Protéines)-cortactin interaction orchestrates directional cell migration via coupling dynamic microtubule plus ends to the cortical cytoskeleton.
Study showed that dynamin 2 and cortactin participate in the formation of F-actin bundles, which stabilize filopodia in migrating cancer cells.
Amplification of 11q13 resulting in overexpression of CTTN/CCND1 (Montrer CCND1 Protéines) was the most prominent finding, which was observed in 13 of 19 ESCC cases.
our data suggest that cortactin and Arp2/3 mediated actin polymerization is implicated in the cell movement during gastrulation and perhaps the development of the central neural system as well.
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
, ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)
, oncogene EMS1
, src substrate cortactin
, mammary tumor and squamous cell carcinoma associated (p80/85 src substrate)
, cortactin isoform B
, src substrate protein p85
, Src substrate cortactin
, src substrate cortactin-like