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Human Cortactin Protein expressed in HEK-293 Cells - ABIN2712518
Labrador-Horrillo, Martínez, Selva-OCallaghan, Trallero-Araguás, Grau-Junyent, Vilardell-Tarrés, Juarez: Identification of a novel myositis-associated antibody directed against cortactin. dans Autoimmunity reviews 2014
Show all 3 Pubmed References
Cortactin expression in carcinoma cells and its known involvement in the EGFR (Montrer EGFR Protéines) pathway suggest a role for this protein as a target for laryngeal squamous cell carcinoma therapy.
Cortactin depletion in HMEC-1 cells results in increased st (Montrer ADM Protéines)ress fibre contractili (Montrer RABGEF1 Protéines)ty and endothelial barrier destabilisation. Secretion of the barrier-stabilising hormone adrenomedullin, which activates Rap1 and counteracts actomyosin contractility, was reduced in supernatants of cortactin-depleted endothelium. Cortactin acts in controlling actomyosin contractility with consequences for endothelial barrier integrity.
Data show that cortactin-mediated p21Cip1 (Montrer CDKN1A Protéines) nuclear export and degradation facilitating MCP1 (Montrer CCL2 Protéines)-induced human aortic smooth muscle cell (HASMC) proliferation.
Mena (Montrer EGFR Protéines)(INV (Montrer INVS Protéines)) promotes invadopodium maturation by inhibiting normal dephosphorylation of cortactin at tyrosine 421 by the phosphatase PTP1B (Montrer PTPN1 Protéines).
CTTN expression increases EGFR (Montrer EGFR Protéines) protein levels and enhances the activation of the MAPK (Montrer MAPK1 Protéines) signaling pathway. CTTN expression also inhibits the ubiquitin-mediated degradation of EGFR (Montrer EGFR Protéines) by suppressing the coupling of c-Cbl (Montrer CBL Protéines) with EGFR (Montrer EGFR Protéines).
the study revealed that PTBP1 (Montrer PTBP1 Protéines) facilitates colorectal cancer migration and invasion activities by inclusion of cortactin exon 11
Overall, the authors find that p27 (Montrer PAK2 Protéines) directly promotes cell invasion by facilitating invadopodia turnover via the Rac1/PAK1 (Montrer PAK1 Protéines)/Cortactin pathway.
Tyrosine dephosphorylation of the cytoskeletal scaffold, cortactin, recruits the RhoA (Montrer RHOA Protéines) antagonist SRGAP1 (Montrer SRGAP1 Protéines) to relax adherens junctions in response to HGF (Montrer HGF Protéines).
cortactin binds to E-cadherin (Montrer CDH1 Protéines), and that a posttranslational modification of cortactin, RhoA (Montrer RHOA Protéines)-induced phosphorylation by protein kinase D1 (PKD1; also known as PRKD1 (Montrer PRKD1 Protéines)) at S298, impairs adherens junction assembly and supports their dissolution.
Unique role for PBF (Montrer PTTG1IP Protéines) in regulating CTTN function to promote endocrine cell invasion and migration.
this paper shows that cortactin deficiency causes increased RhoA (Montrer RHOA Protéines)/ROCK1 (Montrer ROCK1 Protéines)-dependent actomyosin contractility, intestinal epithelial barrier dysfunction, and disproportionately severe dextran sulfate sodium-induced colitis
Secretion of the barrier-stabilising hormone adrenomedullin (Montrer ADM Protéines), which activates Rap1 (Montrer TERF2IP Protéines) and counteracts actomyosin contractility, was reduced in plasma from cortactin-deficient mice. Cortactin plays a role in controlling actomyosin contractility with consequences for endothelial barrier integrity.
These findings suggest that the patterning of podosomes into a sealing zone involves the dynamic interaction between cofilin (Montrer CFL1 Protéines), CTTN, and the microtubule + ends.
AMPK (Montrer PRKAA1 Protéines) phosphorylation of cortactin followed by SIRT1 (Montrer SIRT1 Protéines) deacetylation modulates the interaction of cortactin and cortical-actin in response to shear stress. Functionally, this AMPK (Montrer PRKAA1 Protéines)/SIRT1 (Montrer SIRT1 Protéines) coregulated cortactin-F-actin dynamics is required for endothelial nitric oxide synthase (Montrer NOS3 Protéines) subcellular translocation/activation and is atheroprotective.
Cortactin may have an important role in the development of oral tumors in mice
findings reveal that Keap1 (Montrer KEAP1 Protéines) regulates cell migration by affecting the subcellular localization and activity of cortactin independently of its role in oxidant stress responses.
association of cortactin with Pfn-1 (Montrer PFN1 Protéines) is regulated by c-Abl (Montrer ABL1 Protéines)-mediated cortactin phosphorylation
Cell proliferation, migration and invasion were inhibited by genetic knockdown of EMS1.
our findings suggest that after GnRHa activation, src activity leads to tyrosine phosphorylation of cortactin, which facilitates its association with Arp3 to engage the actin cytoskeleton.
GIT1-cortactin association through GIT1-Spa (Montrer FASL Protéines) homology domain is required for cortactin localization to the leading edge and is essential for endothelial cell directional migration and tumor angiogenesis.
our data suggest that cortactin and Arp2/3 mediated actin polymerization is implicated in the cell movement during gastrulation and perhaps the development of the central neural system as well.
These findings suggest that this common cortactin variant may functionally contribute to ALI predisposition by impeding endothelial wound healing.
Demonstrate a novel regulation and role for cortactin in FVIIa/TF-mediated endothelial cell migration that occurs through a PAR2 (Montrer F2RL1 Protéines) and RhoA (Montrer RHOA Protéines) dependent mechanism.
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
, ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)
, oncogene EMS1
, src substrate cortactin
, mammary tumor and squamous cell carcinoma associated (p80/85 src substrate)
, cortactin isoform B
, src substrate protein p85
, Src substrate cortactin
, src substrate cortactin-like