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anti-Human ERK2 Anticorps:
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Human Polyclonal ERK2 Primary Antibody pour WB - ABIN966091
Li, Wysk, Gonzalez, Davis: Genomic loci of human mitogen-activated protein kinases. dans Oncogene 1994
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Human Polyclonal ERK2 Primary Antibody pour FACS, IHC (p) - ABIN1882175
Munshi, Wu, Mukhopadhyay, Ottaviano, Sassano, Koblinski, Platanias, Stack et al.: Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth ... dans The Journal of biological chemistry 2004
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Human Monoclonal ERK2 Primary Antibody pour ICS - ABIN1176894
Davis: The mitogen-activated protein kinase signal transduction pathway. dans The Journal of biological chemistry 1993
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Human Monoclonal ERK2 Primary Antibody pour WB - ABIN1882240
Sgouras, Athanasiou, Beal, Fisher, Blair, Mavrothalassitis: ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation. dans The EMBO journal 1995
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Human Polyclonal ERK2 Primary Antibody pour WB - ABIN3042634
Li, Chen, Zhang, Chen, Nie, Xu, Gong, Shen, Su, Weng, Tan, Zhao, Zeng, Zhou: SOX9 was involved in TKIs resistance in renal cell carcinoma via Raf/MEK/ERK signaling pathway. dans International journal of clinical and experimental pathology 2015
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Human Monoclonal ERK2 Primary Antibody pour IHC, ELISA - ABIN966090
Whitehurst, Robinson, Moore, Cobb: The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions. dans The Journal of biological chemistry 2004
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Human Monoclonal ERK2 Primary Antibody pour ICC, IHC - ABIN1724654
Hatano, Mori, Oh-hora, Kosugi, Fujikawa, Nakai, Niwa, Miyazaki, Hamaoka, Ogata: Essential role for ERK2 mitogen-activated protein kinase in placental development. dans Genes to cells : devoted to molecular & cellular mechanisms 2003
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Human Monoclonal ERK2 Primary Antibody pour WB - ABIN533235
Rodriguez-Viciana, Tetsu, Tidyman, Estep, Conger, Cruz, McCormick, Rauen: Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. dans Science (New York, N.Y.) 2006
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Human Polyclonal ERK2 Primary Antibody pour WB - ABIN5518657
Ma, Wang, Chen, Chen, Wang, Aisa: Icariin and icaritin stimulate the proliferation of SKBr3 cells through the GPER1-mediated modulation of the EGFR-MAPK signaling pathway. dans International journal of molecular medicine 2014
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Dog (Canine) Monoclonal ERK2 Primary Antibody pour EIA, WB - ABIN126833
Samuels, Karlo, Faruzzi, Pickering, Herrup, Sweatt, Saitta, Landreth: Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
The present study demonstrated that the downregulation of filaggrin (Montrer FLG Anticorps) in the epidermis by toluene is mediated by ERK1/2 and STAT3 (Montrer STAT3 Anticorps)-dependent pathways.
The results of the present study suggested that the therapeutic effect of TGP (Montrer TGM4 Anticorps) on psoriasis may be mediated by modulation of the p38 MAPK (Montrer MAPK14 Anticorps)/NFkappaB (Montrer NFKB1 Anticorps) p65 (Montrer GORASP1 Anticorps) signaling pathway. The results of the present study contribute to the understanding of the role of TGP (Montrer TGM4 Anticorps) in the treatment of psoriasis. The present study provides insights suggesting that p38 MAPK (Montrer MAPK14 Anticorps) may be a novel regulatory signaling pathway for the treatment of psoriasis.
L5-LDL, a naturally occurring mild oxidized LDL, induced G-CSF (Montrer CSF3 Anticorps) and GM-CSF (Montrer CSF2 Anticorps) production in human macrophages through LOX-1 (Montrer OLR1 Anticorps), ERK2, and NF-kappaB (Montrer NFKB1 Anticorps) dependent pathways
the MAPKspecific inhibitor SB203580 attenuated the inhibitory effects of 4HPR on the migration of HepG2 cells. Moreover, we also observed that 4HPR inhibited the activation and expression of myosin light chain kinase (MLCK (Montrer MYLK Anticorps)) in HepG2 cells.
Summarizing the obtained results we can postulate p38 (Montrer CRK Anticorps) implication in H2O2-induced senescence of hMESCs, and suggest p38 (Montrer CRK Anticorps) inhibition as a promising approach in prevention of premature senescence.
TGFB1 (Montrer TGFB1 Anticorps)-mediated PI3K (Montrer PIK3CA Anticorps)/Akt (Montrer AKT1 Anticorps) and p38 MAP kinase (Montrer MAPK14 Anticorps) dependent alternative splicing of fibronectin (Montrer FN1 Anticorps) extra domain A in human podocyte culture has been reported.
These data suggest ebselen may inhibit ROS (Montrer ROS1 Anticorps) production triggered by H. pylori LPS (Montrer IRF6 Anticorps) treatment via GPX2 (Montrer GPX2 Anticorps)/4 instead of TLR4 (Montrer TLR4 Anticorps) signaling and reduce phosphorylation of p38 MAPK (Montrer MAPK14 Anticorps), resulting in altered production of IL8 (Montrer IL8 Anticorps). Ebselen may, therefore, be a potential therapeutic agent to mediate H. pylori LPS (Montrer IRF6 Anticorps)-induced cell damage.
SHP-2 (Montrer PTPN11 Anticorps) may augment the ERK1/2 activity and cell proliferation activity in IL-21 (Montrer IL17C Anticorps) signaling.
intact keratin filaments are regulators for PKB/Akt (Montrer AKT1 Anticorps) and p44 (Montrer GTF2H2 Anticorps)/42 activity, basal and in response to stretch.
High MAPK1 (Montrer MAPK3 Anticorps) expression is associated with gastric cancer.
M-CSF (Montrer CSF1R Anticorps)-evoked ERK1/2 activation was decreased, whereas AKT (Montrer AKT1 Anticorps) activation was enhanced in SHP2 (Montrer PTPN11 Anticorps)-deficient BMMs. ERK1/2, via its downstream target RSK2 (Montrer RPS6KA3 Anticorps), mediates this negative feedback by negatively regulating phosphorylation of M-CSF (Montrer CSF1R Anticorps) receptor at Tyr721 and, consequently, its binding to p85 (Montrer ECM1 Anticorps) subunit of PI3K and PI3K activation.
ERK5 provides a common bypass route in intestinal epithelial cells, which rescues cell proliferation upon abrogation of ERK1/2 signalling, with therapeutic implications in colorectal cancer.
MAPKs play a critical role in the control of cellular responses to cytokines and stressors and involved in the LPS (Montrer TLR4 Anticorps)-induced signaling pathway by which iNOS (Montrer NOS2 Anticorps) is expressed.
The Macrophage Activation Induced by Bacillus thuringiensis Cry1Ac Protoxin Involves ERK1/2 and p38 (Montrer CRK Anticorps) Pathways and the Interaction with Cell-Surface-HSP70 (Montrer HSP70 Anticorps)
persistent distention/stretch on colonic smooth muscle cells could suppress SCF (Montrer KITLG Anticorps) production probably through Ca(2 (Montrer CA2 Anticorps)+) -ERK (Montrer EPHB2 Anticorps)-AP-1 (Montrer JUN Anticorps)-miR (Montrer MLXIP Anticorps)-34c deregulation.
This indicates that TcpC may promote MIP2 (Montrer CXCL2 Anticorps) production in kidney cells through the p38 MAPK (Montrer MAPK14 Anticorps) signaling pathway. Taken together, the data of the present study demonstrated that TcpC can induce MIP2 (Montrer CXCL2 Anticorps) production, which may contribute to the characteristic histological change associated with pyelonephritis.
the hippocampal MAPK oscillation and theta rhythmic oscillations in Nf1 (Montrer NF1 Anticorps) (+/-) mice were disturbed and hinted about a possible mechanism for the brain dysfunction in Nf1 (Montrer NF1 Anticorps) (+/-) mice.
Stress-specific p38 MAPK (Montrer MAPK14 Anticorps) activation is sufficient to drive EGFR (Montrer EGFR Anticorps) endocytosis but not its nuclear translocation
This indicated that RANK might be the binding target of baicalin. In sum, our findings revealed baicalin increased osteoclast maturation and function via p-ERK (Montrer EPHB2 Anticorps)/Mitf (Montrer MITF Anticorps) signalling. In addition, the results suggest that baicalin can potentially be used as a natural product for the treatment of bone fracture
ERK2 role in the osteoclast differentiation.Insulin induces RANK expression via ERK1/2, which contributes to the enhancement of osteoclast differentiation.
The present results suggest that demecolcine might contribute to the activation of the Mos (Montrer MOCOS Anticorps)/MAPK pathway and affect spindle structure
MAPK1 upregulated milk protein (Montrer CSN2 Anticorps) synthesis through the Stat5 (Montrer STAT5A Anticorps) and mTOR (Montrer FRAP1 Anticorps) pathways.
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Cyclin-dependent kinase (Montrer CDK1 Anticorps) inhibition did not affect the expression (mRNA and protein levels) and localization of maturation promoting factor(MPF (Montrer MSLN Anticorps)) and MAPK, and had nearly no effect on kinase activities during maturation.
Thrombospondin 1 (Montrer THBS1 Anticorps), fibronectin (Montrer FN1 Anticorps), and vitronectin (Montrer VTN Anticorps) are differentially dependent upon RAS, ERK1/2, and p38 (Montrer MAPK14 Anticorps) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (Montrer EGR1 Anticorps) nuclear accumulation.
Role of CaMKII (Montrer CAMK2G Anticorps) in hydrogen peroxide activation of p38 MAPK (Montrer MAPK14 Anticorps)/heat shock protein 27 pathway and ERK1/2
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
MAPK1 role in the oocyte maturation
Excess PLAC8 promotes an unconventional ERK2-dependent EMT (Montrer ITK Anticorps) in colon cancer.
ERK1/2-Akt1 (Montrer AKT1 Anticorps) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (Montrer SH3GL1 Anticorps) plays an important role in the development of the myeloid cell through activation of the ERK1 (Montrer MAPK3 Anticorps)/ERK2 pathway
ERK1 (Montrer MAPK3 Anticorps) and ERK2 target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK2 genes involved in cell-migration, mesendoderm differentiation and patterning were identified.
These results demonstrate that induction of Hsp70 (Montrer HSPA1A Anticorps) in response to heat stress is dependent on ERK activation in Pac2 (Montrer PSMG2 Anticorps) cells.
Data define distinct roles for ERK1 (Montrer MAPK3 Anticorps) and ERK2 in developmental cell migration processes during zebrafish embryogenesis.
Here the authors show that CPEB4 activity is regulated by ERK2- and Cdk1-mediated hyperphosphorylation. These phosphorylation events additively activate CPEB4 in M-phase by maintaining it in its monomeric state.
The reciprocal feedback observed between MPF (Montrer MSLN Anticorps) and ERK2 in meiosis is not observed during mitotic M-phase in cell-free Xenopus embryo extracts.
The data suggest a MKK3 * MPK1 * RBK1 phosphorylation cascade that may provide a dynamic module for altering cell expansion.
MKP1 (Montrer DUSP1 Anticorps) is a negative regulator of signaling pathways required for some, but not all, early and late pathogen-associated molecular pattern responses.
MKP1 (Montrer DUSP1 Anticorps) and PTP1 act redundantly to suppress salicylic acid and camalexin biosynthesis, and regulate growth homeostasis and PR gene expression in an MPK3 (Montrer MAPK3 Anticorps)- and MPK6 (Montrer MAPK6 Anticorps)-dependent manner.
Regulation of AtMPK1/2 kinase activity in Arabidopsis might be under the control of signals involved in different kinds of stress.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Agonist stimulation of vascular smooth muscle increases PKC (Montrer FYN Anticorps) activity, which, in turn, increases MKP-1 (Montrer DUSP1 Anticorps) activity and maintains MAPK1 activity at submaximal values.
sub-vasomotor concentration of ET-1 (Montrer EDN1 Anticorps) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (Montrer MAPK14 Anticorps) kinase-mediated production of superoxide from NADPH oxidase (Montrer NOX1 Anticorps) following ETA receptor activation
Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
CSF2 (Montrer CSF2 Anticorps) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK-dependent MTOR (Montrer FRAP1 Anticorps) signal transduction cascades.
PGRN (Montrer GRN Anticorps) inhibits adipogenesis in porcine preadipocytes partially through ERK activation mediated PPARgamma (Montrer PPARG Anticorps) phosphorylation.
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (Montrer MAPK8 Anticorps)/2 dependent.
The authors show that porcine circovirus type 2 (PCV2) activates ERK1/2 in PCV2-infected PK15 cells dependent on viral replication.
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
, MAP kinase 1
, MAP kinase 2
, MAP kinase isoform p42
, MAPK 2
, extracellular signal-regulated kinase 2
, mitogen-activated protein kinase 2
, protein tyrosine kinase ERK2
, MAPK 1
, mitogen activated protein kinase 1
, extracellular-signal-regulated kinase 2
, mitogen-activated protein kinase 1
, MAP kinase
, mitogen-activated protein kinase 1b
, myelin basic protein kinase-like protein
, mitogen-activated protein kinase 1a
, extracellular signal-regulated kinase-2
, extracellular regulated protein 2