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Human ERK2 Protein expressed in Wheat germ - ABIN1310256
Abeydeera, Egli, Cox, Mercier, Conde, Pallan, Mizurini, Sierant, Hibti, Hassell, Wang, Liu, Liu, Martinez, Sood, Lybrand, Frydman, Monteiro, Gomer, Nawrot, Yang: Evoking picomolar binding in RNA by a single phosphorodithioate linkage. dans Nucleic acids research 2016
Human ERK2 Protein expressed in Baculovirus infected Insect Cells - ABIN2001936
Slack, Seternes, Gabrielsen, Keyse: Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1. dans The Journal of biological chemistry 2001
Show all 2 Pubmed References
These findings identified the relationship between ERK1/2 Snitrosylation and phosphorylation.
Our data suggest that TGF-beta1 (Montrer TGFB1 Protéines)-induced chemokinesis in PDAC cells is mediated through a RAC1/NOX4 (Montrer NOX4 Protéines)/ROS (Montrer ROS1 Protéines)/p38 MAPK (Montrer MAPK14 Protéines) cascade.
MAPK1 (Montrer MAPK3 Protéines) expression was markedly upregulated in epithelial ovarian cancer tissues and inversely correlated with miR320 expression.
CRP (Montrer CRP Protéines) bound to surface CD32 (also known as FcgammaRII) on myeloma cells, which activated a pathway mediated by the kinase p38 MAPK (Montrer MAPK14 Protéines) and the transcription factor Twist that enhanced the cells' secretion of osteolytic cytokines.
Cold stress-induced ferroptosis involves the ASK1 (Montrer MAP3K5 Protéines)-p38 (Montrer CRK Protéines) pathway.
our results revealed that Livin induced EMT through the activation of the p38/GSK3beta pathway, which in turn promoted the progression and metastasis of breast cancer, especially for triple-negative breast cancer (TNBC)
A cellular threshold for active ERK1/2 levels determines Raf (Montrer RAF1 Protéines)/MEK (Montrer MAP2K1 Protéines)/ERK (Montrer EPHB2 Protéines)-mediated growth arrest versus death responses.
ERK1/2/p53 (Montrer TP53 Protéines)/PUMA (Montrer BBC3 Protéines) signaling axis is related to cisplatin-induced cell death in ovarian cancer cells.
DANCR was found to mediate the proliferation and osteogenic differentiation of HBMSCs via p38 MAPK (Montrer MAPK14 Protéines) inactivation, but not via extracellular signal-regulated protein kinase (Montrer CDK7 Protéines) (ERK)1 (Montrer MAPK3 Protéines)/2 or c-Jun N-terminal kinase (JNK) MAPKs, but.
SU-005 inhibited both p38g and p38delta auto-phosphorylation in HeLa and HEK293T cells.
MAPKs play a critical role in the control of cellular responses to cytokines and stressors and involved in the LPS (Montrer TLR4 Protéines)-induced signaling pathway by which iNOS (Montrer NOS2 Protéines) is expressed.
The Macrophage Activation Induced by Bacillus thuringiensis Cry1Ac Protoxin Involves ERK1/2 and p38 (Montrer CRK Protéines) Pathways and the Interaction with Cell-Surface-HSP70 (Montrer HSP70 Protéines)
persistent distention/stretch on colonic smooth muscle cells could suppress SCF (Montrer KITLG Protéines) production probably through Ca(2 (Montrer CA2 Protéines)+) -ERK (Montrer EPHB2 Protéines)-AP-1 (Montrer JUN Protéines)-miR (Montrer MLXIP Protéines)-34c deregulation.
This indicates that TcpC may promote MIP2 (Montrer CXCL2 Protéines) production in kidney cells through the p38 MAPK (Montrer MAPK14 Protéines) signaling pathway. Taken together, the data of the present study demonstrated that TcpC can induce MIP2 (Montrer CXCL2 Protéines) production, which may contribute to the characteristic histological change associated with pyelonephritis.
the hippocampal MAPK oscillation and theta rhythmic oscillations in Nf1 (Montrer NF1 Protéines) (+/-) mice were disturbed and hinted about a possible mechanism for the brain dysfunction in Nf1 (Montrer NF1 Protéines) (+/-) mice.
Stress-specific p38 MAPK (Montrer MAPK14 Protéines) activation is sufficient to drive EGFR (Montrer EGFR Protéines) endocytosis but not its nuclear translocation
This indicated that RANK might be the binding target of baicalin. In sum, our findings revealed baicalin increased osteoclast maturation and function via p-ERK (Montrer EPHB2 Protéines)/Mitf (Montrer MITF Protéines) signalling. In addition, the results suggest that baicalin can potentially be used as a natural product for the treatment of bone fracture
ERK2 role in the osteoclast differentiation.Insulin induces RANK expression via ERK1/2, which contributes to the enhancement of osteoclast differentiation.
Suppressing P38 (Montrer CRK Protéines) promoted adipogenic trans-differentiation and intensified adipolytic metabolism in differentiated cells. However, inhibition of ERK1/2 had the opposite effects on adipogenesis and no effect on adipolysis. Blocking JNK (Montrer MAPK8 Protéines) weakly blocked trans-differentiation but stimulated adipolysis and induced apoptosis.
Betacellulin (Montrer BTC Protéines) promotes the proliferation of corneal epithelial stem cells through the phosphorylation of Erk1 (Montrer MAPK3 Protéines)/Erk2.
The present results suggest that demecolcine might contribute to the activation of the Mos (Montrer MOCOS Protéines)/MAPK pathway and affect spindle structure
MAPK1 upregulated milk protein (Montrer CSN2 Protéines) synthesis through the Stat5 (Montrer STAT5A Protéines) and mTOR (Montrer FRAP1 Protéines) pathways.
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Cyclin-dependent kinase (Montrer CDK1 Protéines) inhibition did not affect the expression (mRNA and protein levels) and localization of maturation promoting factor(MPF (Montrer MSLN Protéines)) and MAPK, and had nearly no effect on kinase activities during maturation.
Thrombospondin 1 (Montrer THBS1 Protéines), fibronectin (Montrer FN1 Protéines), and vitronectin (Montrer VTN Protéines) are differentially dependent upon RAS, ERK1/2, and p38 (Montrer MAPK14 Protéines) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (Montrer EGR1 Protéines) nuclear accumulation.
Role of CaMKII (Montrer CAMK2G Protéines) in hydrogen peroxide activation of p38 MAPK (Montrer MAPK14 Protéines)/heat shock protein 27 pathway and ERK1/2
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
Excess PLAC8 promotes an unconventional ERK2-dependent EMT (Montrer ITK Protéines) in colon cancer.
ERK1/2-Akt1 (Montrer AKT1 Protéines) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (Montrer SH3GL1 Protéines) plays an important role in the development of the myeloid cell through activation of the ERK1 (Montrer MAPK3 Protéines)/ERK2 pathway
ERK1 (Montrer MAPK3 Protéines) and ERK2 target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK2 genes involved in cell-migration, mesendoderm differentiation and patterning were identified.
These results demonstrate that induction of Hsp70 (Montrer HSPA1A Protéines) in response to heat stress is dependent on ERK activation in Pac2 (Montrer PSMG2 Protéines) cells.
Data define distinct roles for ERK1 (Montrer MAPK3 Protéines) and ERK2 in developmental cell migration processes during zebrafish embryogenesis.
Here the authors show that CPEB4 activity is regulated by ERK2- and Cdk1-mediated hyperphosphorylation. These phosphorylation events additively activate CPEB4 in M-phase by maintaining it in its monomeric state.
The reciprocal feedback observed between MPF (Montrer MSLN Protéines) and ERK2 in meiosis is not observed during mitotic M-phase in cell-free Xenopus embryo extracts.
The data suggest a MKK3 * MPK1 * RBK1 phosphorylation cascade that may provide a dynamic module for altering cell expansion.
MKP1 (Montrer DUSP1 Protéines) is a negative regulator of signaling pathways required for some, but not all, early and late pathogen-associated molecular pattern responses.
MKP1 (Montrer DUSP1 Protéines) and PTP1 act redundantly to suppress salicylic acid and camalexin biosynthesis, and regulate growth homeostasis and PR gene expression in an MPK3 (Montrer MAPK3 Protéines)- and MPK6 (Montrer MAPK6 Protéines)-dependent manner.
Regulation of AtMPK1/2 kinase activity in Arabidopsis might be under the control of signals involved in different kinds of stress.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Agonist stimulation of vascular smooth muscle increases PKC (Montrer FYN Protéines) activity, which, in turn, increases MKP-1 (Montrer DUSP1 Protéines) activity and maintains MAPK1 activity at submaximal values.
sub-vasomotor concentration of ET-1 (Montrer EDN1 Protéines) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (Montrer MAPK14 Protéines) kinase-mediated production of superoxide from NADPH oxidase (Montrer NOX1 Protéines) following ETA receptor activation
Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
CSF2 (Montrer CSF2 Protéines) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK-dependent MTOR (Montrer FRAP1 Protéines) signal transduction cascades.
PGRN (Montrer GRN Protéines) inhibits adipogenesis in porcine preadipocytes partially through ERK activation mediated PPARgamma (Montrer PPARG Protéines) phosphorylation.
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (Montrer MAPK8 Protéines)/2 dependent.
The authors show that porcine circovirus type 2 (PCV2) activates ERK1/2 in PCV2-infected PK15 cells dependent on viral replication.
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
, MAP kinase 1
, MAP kinase 2
, MAP kinase isoform p42
, MAPK 2
, extracellular signal-regulated kinase 2
, mitogen-activated protein kinase 2
, protein tyrosine kinase ERK2
, MAPK 1
, mitogen activated protein kinase 1
, extracellular-signal-regulated kinase 2
, mitogen-activated protein kinase 1
, MAP kinase
, mitogen-activated protein kinase 1b
, myelin basic protein kinase-like protein
, mitogen-activated protein kinase 1a
, extracellular signal-regulated kinase-2
, extracellular regulated protein 2