Aperçu des produits pour anti-GCK (GCK) Anticorps

Full name:: anti-Glucokinase (Hexokinase 4) Anticorps (GCK)

Chez www.anticorps-enligne.fr sont 154 Glucokinase (Hexokinase 4) (GCK) Anticorps de 25 de différents fournisseurs disponibles. De plus, nous expédions GCK Kits (71) et GCK Protéines (66) et beaucoup plus de produits pour cette protéine. Un total de 302 GCK produits sont actuellement listés.

Synonymes:: BA4487, FGQTL3, GCK, gck-A, Gk, glk, Gls006, glucokinase, GLUKA, hhf3, hk4, hkiv, hxkp, LGLK, mody2, RNGK2

afficher tous les anticorps	Gène	GeneID	UniProt
	GCK	2645	P35557
	GCK	103988	P52792
	GCK	24385	P17712
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anti-Human GCK Anticorps:

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Pathways pertinentes pour anti-GCK Anticorps

Regulation of Carbohydrate Metabolic Process

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anti-GCK Anticorps mieux référencés

Human Monoclonal GCK Primary Antibody pour ELISA, WB - ABIN969172 : Barbetti, Cobo-Vuilleumier, Dionisi-Vici, Toni, Ciampalini, Massa, Rodriguez-Bada, Colombo, Lenzi, Garcia-Gimeno, Bermudez-Silva, Rodriguez de Fonseca, Banin, Aledo, Baixeras, Sanz, Cuesta-Muñoz: Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene. dans Molecular endocrinology (Baltimore, Md.) 2009 (PubMed)
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Human Monoclonal GCK Primary Antibody pour ELISA, WB - ABIN966192 : Yoshida, Kato, Yokoi, Oguri, Watanabe, Metoki, Yoshida, Satoh, Aoyagi, Nishigaki, Nozawa, Yamada: Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. dans International journal of molecular medicine 2009 (PubMed)
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Human Polyclonal GCK Primary Antibody pour IF (p), IHC (p) - ABIN734558 : Wang, Liu, Chen, Duan, Chen, Xi: Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus. dans Journal of diabetes research 2017 (PubMed)
Human Polyclonal GCK Primary Antibody pour FACS, IF - ABIN411493 : Huang, Chou, Lee, Chen, Chen, Tao, Shih: MicroRNA-130a can inhibit hepatitis B virus replication via targeting PGC1α and PPARγ. dans RNA (New York, N.Y.) 2015 (PubMed)
Cow (Bovine) Polyclonal GCK Primary Antibody pour WB - ABIN2788816 : Tian, Liu, Wang, Dong, Su, Ma, Zhang: Anti-diabetes effect of chronic intermittent hypobaric hypoxia through improving liver insulin resistance in diabetic rats. dans Life sciences 2016 (PubMed)

Plus d’anticorps contre GCK partenaires d’interaction

Human Glucokinase (Hexokinase 4) (GCK) interaction partners

Our results suggest that the polymorphism of CYP3A4 (Montrer CYP3A4 Anticorps) *18B and GCK G-30A might affect the new-onset diabetes after transplantation (NODAT) development under tacrolimus-based immunotherapy. We suspect that the depression of GCK function may be a crucial pathogenic factor of tacrolimus-induced NODAT in variant carrier with A allele of GCK, but not be simply reflecting of glucose change.
Data suggest that the following genetic modifications are involved in neonatal diabetes mellitus patients in Oman: (1) mutation in KCNJ11 (Montrer KCNJ11 Anticorps) (potassium voltage-gated channel subfamily J member 11; one patient); (2) mutation in GCK (glucokinase); (3) mutation in SLC2A2 (Montrer SLC2A2 Anticorps) (glucose transporter type 2); (4) chromosome 6q24 methylation abnormalities.
GCK gene mutations were detected in Chinese children and their family members with typical clinical features of glucokinase-maturity-onset diabetes of the young. Four novel mutations were detected.
The studies screening criteria allowed for the identification of glucokinase (GCK)-deficient patients who were diagnosed with gestational diabetes, and these mutations in the GCK gene were not common in Chinese women with gestational diabetes.
Functional characterization of MODY2 mutations in the nuclear export signal of glucokinase.
44 different mutations affecting the GCK and co-segregating with the clinical phenotype of MODY (Montrer HNF4A Anticorps) were identified.
Twenty-five different variants were identified in GCK gene (30 probands-61% of positivity), and 7 variants in HNF1A (Montrer HNF1A Anticorps) (10 probands-17% of positivity). Fourteen of them were novel (12- GCK /2- HNF1A (Montrer HNF1A Anticorps) ). ACMG guidelines were able to classify a large portion of variants as pathogenic (36%- GCK /86%- HNF1A (Montrer HNF1A Anticorps) ) and likely pathogenic (44%- GCK /14%- HNF1A (Montrer HNF1A Anticorps) ), with 16% (5/32) as uncertain significance.
a nuclear import of glucokinase mediated by a redundant mechanism, involving a nuclear localization signal, and which is modulated by its SUMOylation, is reported.
La variante confirmada of the glucokinase gene para esta (Montrer RPL11 Anticorps) familia es c.148C>T, p.His50Tyr. Tiene caracter patogenico, dado que (Montrer DBT Anticorps) produce una disminucion de la actividad enzimatica de GCK y ha sido reportada en la literatura
described the clinical and genetic presentation of four families with activating GCK mutations The clinical phenotype of the GCK activating mutation carriers was heterogeneous, the severity of symptoms and age at presentation varied markedly between affected individuals, even within the same family.

Mouse (Murine) Glucokinase (Hexokinase 4) (GCK) interaction partners

a nuclear import of glucokinase mediated by a redundant mechanism, involving a nuclear localization signal, and which is modulated by its SUMOylation, is reported.
Glucokinase governs an alpha-cell metabolic pathway that suppresses secretion at or above normoglycemic levels; abnormal suppression of glucagon (Montrer GCG Anticorps) secretion deregulates hepatic glucose metabolism and, over time, induces a pre-diabetic phenotype.
GCK-dependent glycolysis regulates Treg cell migration.
GCK expression is regulated by nutrient-sensing O-linked beta-N-acetylglucosaminylation cycling in liver.
Absence of Gck expression did not prevent the glucose responsiveness of glucose-excited or glucose-inhibited Sf1 (Montrer SF1 Anticorps) neurons in either sex. Thus Gck in the VMN plays a sex-specific role in the glucose-dependent control of autonomic nervous activity; this is, however, unrelated to the control of the firing activity of classical glucose-responsive neurons.
Using a mutant GCK gene (GCK 262) with a knocked out cytosine at position 2643 results in lower protein expression and more ubiquitination-led protein degradation compared with wild-type GCK (GCK 261)
lncLGR facilitates the recruitment of hnRNPL (Montrer HNRNPL Anticorps) to the GCK promoter and suppresses GCK transcription.
Given that acetylated GKRP (Montrer GCKR Anticorps) may affiliate with type-2 diabetes mellitus (T2DM), understanding the mechanism of GKRP (Montrer GCKR Anticorps) acetylation in the liver could reveal novel targets within the GK-GKRP (Montrer GCKR Anticorps) pathway, for treating T2DM and other metabolic pathologies.
These results suggest a mechanism for integrative control over GCK activation and, therefore, glucose metabolism and insulin (Montrer INS Anticorps) secretion through regulation of cytoplasmic Ca(2 (Montrer CA2 Anticorps)+) levels.
GHR (Montrer GHR Anticorps) knockdown caused increased glucokinase mRNA and protein levels.

Rainbow Trout (Oncorhynchus mykiss) Glucokinase (Hexokinase 4) (GCK) interaction partners

This study using immunoreactive techniques, we have demonstrated in those specific areas of the rainbow trout brain previously described as glucosensor the presence of glucokinase in different cell types.

Xenopus laevis Glucokinase (Hexokinase 4) (GCK) interaction partners

GKRP (Montrer GCKR Anticorps) binds to a super-open conformation of GK mainly through hydrophobic interaction, inhibiting the GK activity by locking a small domain of GK.

GCK profil antigène

Antigen Summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

Alternative names and synonyms associated with GCK

glucokinase (GCK) anticorps
glucokinase (Gck) anticorps
glucokinase (glcK) anticorps
glucokinase (Bphyt_1025) anticorps
glucokinase (Halhy_6548) anticorps
glucokinase (gk) anticorps
glucokinase (hexokinase 4) L homeolog (gck.L) anticorps
glucokinase (hexokinase 4) (gck) anticorps

BA4487 anticorps
FGQTL3 anticorps
GCK anticorps
gck-A anticorps
Gk anticorps
glk anticorps
Gls006 anticorps
glucokinase anticorps
GLUKA anticorps
hhf3 anticorps
hk4 anticorps
hkiv anticorps
hxkp anticorps
LGLK anticorps
mody2 anticorps
RNGK2 anticorps

Protein level used designations for GCK

ATP:D-hexose 6-phosphotransferase , HK IV , glucokinase , hexokinase D, pancreatic isozyme , hexokinase type IV , hexokinase-4 , hexokinase-D , hexokinase 4 , glucokinase (hexokinase 4, maturity onset diabetes of the young 2) , HK4

GENE ID	SPECIES
2645	Homo sapiens
103988	Mus musculus
606490	Canis lupus familiaris
616576	Bos taurus
1087979	Bacillus anthracis str. Ames
2797963	Listeria monocytogenes serotype 4b str. F2365
3728664	Carboxydothermus hydrogenoformans Z-2901
6284349	Burkholderia phytofirmans PsJN
10590758	Haliscomenobacter hydrossis DSM 1100
100037406	Felis catus
100135866	Oncorhynchus mykiss
378602	Xenopus laevis
100124905	Xenopus (Silurana) tropicalis
24385	Rattus norvegicus
430370	Gallus gallus
100051836	Equus caballus
100514142	Sus scrofa
100717630	Cavia porcellus
100341946	Oryctolagus cuniculus

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Show all anti-Glucokinase (Hexokinase 4) (GCK) Anticorps with Pubmed References