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Human Polyclonal HSPB1 Primary Antibody pour IHC - ABIN966312
Scrimin, Axia, Tremolada, Pillon, Capello, Zanesco: Conversational strategies with parents of newly diagnosed leukaemic children: an analysis of 4880 conversational turns. dans Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2005
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Human Polyclonal HSPB1 Primary Antibody pour IHC - ABIN966313
Jordan, Brownstone, Noga: Control of functional systems in the brainstem and spinal cord. dans Current opinion in neurobiology 1993
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Human Polyclonal HSPB1 Primary Antibody pour IF (p), IHC (p) - ABIN672441
Wang, Yang, Liu, Zhou, Wu, Qiao, Li, Wang: Dietary supplementation with the probiotic Lactobacillus fermentum I5007 and the antibiotic aureomycin differentially affects the small intestinal proteomes of weanling piglets. dans The Journal of nutrition 2011
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Human Polyclonal HSPB1 Primary Antibody pour IHC, WB - ABIN2779293
Lelj-Garolla, Mauk: Self-association and chaperone activity of Hsp27 are thermally activated. dans The Journal of biological chemistry 2006
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Human Monoclonal HSPB1 Primary Antibody pour FACS, IF - ABIN966308
Langer, Ott, Specht, Becker, Lordick, Burian, Herrmann, Schrattenholz, Cahill, Schwaiger, Hofler, Wester: Protein expression profiling in esophageal adenocarcinoma patients indicates association of heat-shock protein 27 expression and chemotherapy response. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2008
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Human Polyclonal HSPB1 Primary Antibody pour ICC, IF - ABIN4319980
Stice, Chen, Kim, Jung, Tran, Liu, Knowlton: 17β-Estradiol, aging, inflammation, and the stress response in the female heart. dans Endocrinology 2011
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Human Polyclonal HSPB1 Primary Antibody pour IHC, IHC (p) - ABIN4319981
Azimi, Pernemalm, Frostvik Stolt, Hansson, Lehtiö, Egyházi Brage, Hertzman Johansson: Proteomics analysis of melanoma metastases: association between S100A13 expression and chemotherapy resistance. dans British journal of cancer 2014
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Dog (Canine) Polyclonal HSPB1 Primary Antibody pour FACS, ICC - ABIN1027725
Ehrnsperger, Gräber, Gaestel, Buchner: Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation. dans The EMBO journal 1997
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The expression of HSP27 was approximately 2-fold higher in apical periodontitis. Next, an increased expression of HSP27 was detected in epithelial cells
Findings indicate the heat-shock protein 27 (Hsp27 (Montrer HSP27 Anticorps)) pathway as a therapeutic target for the management of conditions featuring dysregulated interleukin 1 beta (IL-1beta (Montrer IL1B Anticorps)) production.
Increased protein level of HSP27 through SUMO2 (Montrer SUMO2 Anticorps)/3-mediated SUMOylation plays crucial roles in the progression of primary hepatocellular carcinoma.
When the correlations of the markers with the response to neoadjuvant chemotherapy were examined, only high pre-chemotherapy levels of cytoplasmic HSPB1/p correlated with a poor clinical and pathological response to neoadjuvant cisplatin chemotherapy (p = 0.056) suggesting that this marker could be useful opening its study in a larger number of cases.
Exposure to cetuximab and various concentration of AG490, an inhibitor of JAK2 (Montrer JAK2 Anticorps), STAT3 (Montrer STAT3 Anticorps) and HSP27 protein levels, except in the KRAS G12V mutant line, SW620...cetuximab may promote SN38 sensitivity via suppression of HSP27, through blocking the JAK (Montrer JAK3 Anticorps)/STAT (Montrer STAT1 Anticorps) signaling pathway, and shows synergistic effects when combined with SN38 in wild-type RAS CRC (Montrer CALR Anticorps) cells.
we concluded that HSP27-silenced placenta-derived multipotent cells differentiated into neurons possessing the characteristics of functional glutamatergic neurons.
Data show that Hsp27increases degradation rate of ubiquitinated MST1 (Montrer MST1 Anticorps) and therefore interrupts the Hippo pathway kinase cascade. Consequently YAP (Montrer YAP1 Anticorps) and TAZ (Montrer TAZ Anticorps) are less phosphorylated, free to translocate into the nucleus promoting a malignant phenotype. These findings underscore the central importance of Hsp27 in regulating multiple signaling pathways that promote tumor aggressiveness.
upregulation of Hsp27 is a common phenomenon shared between pregnancies in patients with preterm prelabor rupture of membranes and spontaneous preterm labor with intact membranes
HSP27 is an independent predictor of prognosis in chronic HF
Hsp27 may up-regulate the expression of ABCA1 (Montrer ABCA1 Anticorps) and promotes cholesterol efflux through activation of the PI3K (Montrer PIK3CA Anticorps)/PKCzeta (Montrer PRKCZ Anticorps)/Sp1 (Montrer PSG1 Anticorps) signal pathway in THP-1 (Montrer GLI2 Anticorps) macrophage-derived foam cells
HSP27 functions as a negative regulator in the PDGF (Montrer PDGFA Anticorps)-BB-stimulated migration of osteoblasts.
HspB1 is recruited to sites of increased traction force in cells geometrically constrained on micropatterned substrates. Findings elucidate a molecular pathway by which a mechanical signal is transduced via activation of p38 MAPK (Montrer MAPK14 Anticorps) to influence actin remodeling and cell migration via a zyxin (Montrer ZYX Anticorps)-independent process.
Study report a novel interaction between mutant HSPB1-P182L and the RNA binding protein PCBP1 (Montrer PCBP1 Anticorps), leading to a reduction in its translational repression activity. Identifying PCBP1 (Montrer PCBP1 Anticorps) mRNA targets revealed a marked prevalence for an RNA recognition motif, preferably seen in their 5' and 3'UTRs. Findings further support a role for mutant HSPB1 in neurodegenerative diseases.
Expression of a phosphomimetic HSPB1 mutant in astrocytes reduced toxicity to motor neurons.
AMPK (Montrer PRKAA1 Anticorps)-mediated HSPB1 expression enhanced insulin (Montrer INS Anticorps) sensitivity in the skeletal muscle.
e confirmed the modulatory effect of Hspb1 on Purkinje cell degeneration (Montrer AGTPBP1 Anticorps) in vivo, as knockdown by Hspb1 shRNA significantly enhanced neuron loss. These results suggest that strategies to promote HSPB1 activity may slow the rate of cerebellar degeneration in NPC (Montrer NPC1 Anticorps) disease and highlight the use of bioinformatics tools to uncover pathways leading to neuronal protection in neurodegenerative disorders
Dp71Delta78-79 dystrophin (Montrer DMD Anticorps) mutant stimulates neurite outgrowth in cultured neuronal cells via upregulation and phosphorylation of HspB1.
HSPB1 depletion in a mouse model of lung tumorigenesis induced the endothelial-to-mesenchymal transition
Overexpression of HSP27-S135F protein causes peripheral neuropathy. The mouse model can be applied to future development of therapeutic strategies forhereditary motor neuropathy (dHMN) and Charcot-Marie-Tooth disease type 2 F.
cardiac HMGB1 (Montrer HMGB1 Anticorps) increases HSPB1 expression and attenuates cardiomyocyte apoptosis associated with doxorubicin-induced cardiomyopathy.
Loss of HspB1 specifically reduces myofibril size in embryonic craniofacial muscles.
Results show the sequence, expression, regulation, and function of a zebrafish protein (zfHsp27) and define zebrafish as a new model for the study of Hsp27 function.
initial upregulation of hsp27 expression occurs during early gastrulation
hspb1 is expressed during development
Hsp27 is dispensable for zebrafish morphogenesis but could play a role in long-term maintenance of heart and muscle tissues.
The data support a mechanism of Hsp27 function where interactions with the titin (Montrer TTN Anticorps) filament system protect myofibrils from stress-induced degradation.
Xenopus HSP27, like HSP30, is a developmentally-regulated heat-inducible molecular chaperone (Montrer HSP90AA1 Anticorps).
Here, heat shock protein 27 (Hsp27 (Montrer HSP27 Anticorps)) has been identified as a novel binding partner of NS5A, a protein functioning in classical swine fever virus genome replication. Further findings clearly demonstrate that the inhibition of viral replication by Hsp27 is mediated via the NF-kappaB (Montrer NFKB1 Anticorps) signaling pathway.
It indicated that Hsp27 was required for porcine circovirus type 2 replication in PK-15 cells culture.
HSP27 expression is gut (Montrer GUSB Anticorps) region- and cell type-specific in response to dietary components, microbes, and microbial metabolites to which the mucosa surface is exposed.
These results indicate that Hsp27 expression in the porcine gut (Montrer GUSB Anticorps) could be associated with specific dietary fiber components but not the overall microbiota diversity.
Data suggest that targeting HSP27 might offer a useful strategy in cancer treatment.
Data show that the expression of HSP27 and CLIC1 (Montrer CLIC1 Anticorps) was strongly positive in 61 (59.2%) and 49 cases (47.6%), respectively.
Data suggest that HSP27 enhanced the metastatic property of NPC (Montrer NPC1 Anticorps) cells probably via the NF-kappaB (Montrer NFKB1 Anticorps)-mediated activation of MMPs.
Hsp27 expression and its direct chaperoning interaction increase Akt (Montrer AKT1 Anticorps) stability and p21 (Montrer CDKN1A Anticorps) phosphorylation and nuclear-to-cytoplasm translocation, both essential effects for the survival of ultraviolet-induced DNA-damaged cells.
HSP27 could be a good candidate involved in migration and/or function of neutrophils within the porcine endmetrium.
HSP27 and HSP70 (Montrer HSP70 Anticorps) may be used as differential markers to distinguish conventional and low grade central osteosarcoma.
These findings suggest that HSPB1 mediates androgen signaling by binding directly to androgen receptor (Montrer AR Anticorps) and then enhancing androgen-mediated myogenesis in myogenic cells.
HSPB1 could have an important role during testosterone-related myogenesis.
CaMKII (Montrer CAMK2G Anticorps) is required for redox-sensitive activation of p38 MAPK (Montrer MAPK14 Anticorps)/heat shock protein 27 (Montrer HSP27 Anticorps) pathway and ERK1/2
The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN).
28 kDa heat shock protein
, HSP 27
, estrogen-regulated 24 kDa protein
, heat shock 27 kDa protein
, heat shock 27kD protein 1
, heat shock protein beta-1
, stress-responsive protein 27
, HSP 25
, growth-related 25 kDa protein
, heat shock 25 kDa protein
, heat shock 27kDa protein 1
, heat shock protein, 25 kDa
, truncated hsp25
, heat shock 27 kDa protein 1
, 25 kDa heat shock protein
, 25 kDa IAP
, actin polymerization inhibitor
, inhibitor of actin polymerization
, heat-shock protein
, heat shock protein 27