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anti-Human JNK Anticorps:
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Cow (Bovine) Polyclonal JNK Primary Antibody pour IF (p), IHC (p) - ABIN732368
Rosenzweig, Djap, Ou, Quinn: Mechanical injury of bovine cartilage explants induces depth-dependent, transient changes in MAP kinase activity associated with apoptosis. dans Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2012
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Human Monoclonal JNK Primary Antibody pour IP, WB - ABIN967330
Adler, Fuchs, Kim, Kraft, King, Pelling, Ronai: jun-NH2-terminal kinase activation mediated by UV-induced DNA lesions in melanoma and fibroblast cells. dans Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996
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Human Monoclonal JNK Primary Antibody pour FACS, WB - ABIN968867
Fleming, Armstrong, Morrice, Paterson, Goedert, Cohen: Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. dans The Biochemical journal 2001
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Human Monoclonal JNK Primary Antibody pour FACS, WB - ABIN968866
Kyriakis, Avruch: Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. dans Physiological reviews 2001
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Human Monoclonal JNK Primary Antibody pour ICS - ABIN1177076
Huang, Shi, Chi: Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination. dans Cytokine 2009
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Human Monoclonal JNK Primary Antibody pour ICS - ABIN1177075
Wagner, Nebreda: Signal integration by JNK and p38 MAPK pathways in cancer development. dans Nature reviews. Cancer 2009
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Caenorhabditis elegans (C. elegans) Polyclonal JNK Primary Antibody pour IHC (p), IHC - ABIN151424
Oh, Mukhopadhyay, Svrzikapa, Jiang, Davis, Tissenbaum: JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. dans Proceedings of the National Academy of Sciences of the United States of America 2005
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Human Polyclonal JNK Primary Antibody pour IHC, IHC (p) - ABIN4327961
Gao, Wang, Zhang, Yu, Ji, Wang, Zhang, Jiang, Jin, Huang, Zhang, Li: Tumor necrosis factor receptor-associated factor 5 (Traf5) acts as an essential negative regulator of hepatic steatosis. dans Journal of hepatology 2016
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Human Polyclonal JNK Primary Antibody pour WB - ABIN3043004
Zheng, Liu, Liu, Ma, Zhou, Chen, Chang, Wang, Yang, He: Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH?SY5Y human neuroblastoma cells. dans Molecular medicine reports 2014
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Human Polyclonal JNK Primary Antibody pour IF (p), IHC (p) - ABIN747713
Li, Qiu, Lin, He, Hua, Yuan, Liu, Wei: c-Jun N-terminal kinase is upregulated in patients with hypospadias. dans Urology 2012
Cell fusion during wound healing in Drosophila larval epidermis occurred primarily in the wound vicinity, where JAK (Montrer JAK3 Anticorps)/STAT (Montrer STAT1 Anticorps) activation was suppressed by fusion-inducing JNK signaling.
aken together, these results reveal that inactivation of Rpd3 (Montrer HDAC1 Anticorps) independently regulates JNK and Yki (Montrer YAP1 Anticorps) activities and that both Hippo and JNK signaling pathways contribute to Rpd3 (Montrer HDAC1 Anticorps) RNAi-induced apoptosis.
Data show that JNK signalling inhibits the growth of losers, while JAK (Montrer JAK3 Anticorps)/STAT (Montrer STAT1 Anticorps) signalling promotes competition-induced winner cell proliferation.
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr (Montrer EGFR Anticorps)) pathway in the lateral epidermis for sustained dpp (Montrer TGFb Anticorps) expression in the LE. Specifically, we demonstrate that Egfr (Montrer EGFR Anticorps) pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling
n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing
malignant transformation of the ras(V12)scrib(1 (Montrer SCRIB Anticorps)) tumors requires bZIP protein Fos, the ETS (Montrer ETS1 Anticorps)-domain factor Ets21c and the nuclear receptor Ftz-F1 (Montrer NR5A2 Anticorps), all acting downstream of Jun-N-terminal kinase.
Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.
ROS (Montrer ROS1 Anticorps)/JNK/p38 (Montrer MAPK14 Anticorps)/Upd (Montrer UROD Anticorps) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (Montrer NOTCH1 Anticorps)-Src (Montrer SRC Anticorps) synergy.
This study demonstrated that the mechanism by which Bsk (Montrer FRK Anticorps) is required for pruning is through reducing the membrane levels of the adhesion molecule (Montrer NCAM1 Anticorps) Fasciclin II (Montrer NCAM2 Anticorps) (FasII)
High JNK expression is associated with non-small-cell lung cancer.
These data suggested that Annexin A2 (Montrer ANXA2 Anticorps) induces cisplatin resistance of non-small cell lung cancer (NSCLC)via regulation of JNK/c-Jun/p53 (Montrer TP53 Anticorps) signaling, and provided an evidence that blockade of Annexin A2 (Montrer ANXA2 Anticorps) could serve as a novel therapeutic approach for overcoming drug resistance in NSCLCs
Data suggest that H2O2 regulates cell death in granulosa cells via the ROS (Montrer ROS1 Anticorps)-JNK-p53 (Montrer TP53 Anticorps) pathway.
High expression of JNK is associated with invasion of gastric cancer.
JNK activation and signaling in extrahepatic cholangiocarcinoma is regulated by L1CAM.JNK role in cell migration in extrahepatic cholangiocarcinoma.
Thus, the present study indicated that parkin (Montrer PARK2 Anticorps) knockout inhibits neural stem cell differentiation by JNK-dependent proteasomal degradation of p21 (Montrer CDKN1A Anticorps).
JNK activation contributes to glioma cell parthanatos caused by oxidative stress via increase of intracellular reactive oxygen species generation.
ERK1 (Montrer MAPK3 Anticorps) Directly Interacts With JNK1 Leading to Regulation of JNK1/c-Jun (Montrer JUN Anticorps) Activity and Cell Transformation.
TGM2 (Montrer TGM2 Anticorps) is involved in amyloid-beta (1-42)-induced pro-inflammatory activation via AP1 (Montrer FOSB Anticorps)/JNK signaling pathways in cultured monocytes.
NleL-induced JNK ubiquitylation, particularly mono-ubiquitylation at the Lys (Montrer LYZ Anticorps) 68 residue of JNK, impairs JNK's interaction with an upstream kinase MKK7 (Montrer MAP2K7 Anticorps), thus disrupting JNK phosphorylation and activation.
this study establishes that JNK1 is a key mediator of osteoblast function in vivo and in vitro.
Jnk1 deficiency inhibits the development of neural stem cells/precursors
Suppressing P38 (Montrer CRK Anticorps) promoted adipogenic trans-differentiation and intensified adipolytic metabolism in differentiated cells. However, inhibition of ERK1/2 had the opposite effects on adipogenesis and no effect on adipolysis. Blocking JNK weakly blocked trans-differentiation but stimulated adipolysis and induced apoptosis.
the effects of JNK1 deficiency in an experimental model of familial Alzheimer's disease, was investigated.
Irradiation coupled with JNK inhibition in beta1 integrin -/- transgenic adenocarcinoma of prostate (TRAMP) leads to increased levels of nuclear focal adhesion kinase (FAK) in tumor cells.
transgenic mice overexpressing sPLA2 -IIA (Montrer PLA2G2A Anticorps) keratinocytes showed enhanced activation of EGFR (Montrer EGFR Anticorps) and JNK1/2 that led to c-Jun (Montrer JUN Anticorps) activation.
p53 (Montrer TP53 Anticorps) plays a novel protective role in APAP induced liver injury through inhibiting the activation of JNK, a key mediator in APAP-induced oxidative stress.
We crossed Ptf1a (Montrer PTF1A Anticorps)(Cre/+) ;Kras(G12D/+) mice with JNK1(-/-) mice to generate Ptf1a (Montrer PTF1A Anticorps)(Cre/+) ;Kras(G12D/+) ;JNK1(-/-) (Kras;JNK1(-/-) ) mice. Tumor weight was significantly lower in Kras;JNK1(-/-) mice than in Kras;JNK1(+/-) mice, whereas histopathological features were similar.we concluded that inhibition of activated JNK in pancreatic tumor stroma could be a potential therapeutic target to increase Ccl20 (Montrer CCL20 Anticorps) secretion
BOC (Montrer BOC Anticorps) interacts with ABL (Montrer ABL1 Anticorps) and activates JNK thereby promoting neuronal differentiation and neurite outgrowth.
Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus
The results of this study suggest that JNK has a role in the disassembly adherens junctions by means of endocytosis that is required during buccopharyngeal membrane perforation.
Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (Montrer CASP3 Anticorps)-dependent Proteolysis of JNK1-2 and Bid (Montrer BID Anticorps).
JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (Montrer GUSB Anticorps).
Data show that the death pathway is independent of ERK (Montrer MAPK1 Anticorps) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (Montrer CDK1 Anticorps) and JNK.
study reports MPK8 connects protein phosphorylation, Ca(2 (Montrer CA2 Anticorps))+ and ROS (Montrer ROS1 Anticorps) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (Montrer CA2 Anticorps))+/CaMs and MAP kinase (Montrer MAPK1 Anticorps) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (Montrer ROS1 Anticorps) homeostasis
our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
P38 (Montrer MAPK14 Anticorps) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
A dorsalization pathway that is exerted by Axin (Montrer AXIN1 Anticorps)/JNK signaling and its inhibitor Aida (Montrer AIDA Anticorps) during vertebrate embryogenesis, is defined.
JNK-Mmp13 (Montrer MMP13 Anticorps) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
Findings indicate the MIG-15/JNK-1 pathway can restrict both glutamatergic synapse formation and short-term learning.
Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin (Montrer INS Anticorps)-IGF-1 (Montrer IGF1 Anticorps) signalling (IIS) pathway to modulate longevity. In support of in vivo results in silico docking study of UA with C. elegans JNK-1 ATP-binding site suggested promising binding affinity exhibiting binding energy of -8.11 kcalmol(-1). UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacologi
JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.
The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.
the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (Montrer MAPK1 Anticorps) (MAPK (Montrer MAPK1 Anticorps)) signaling pathway, which is regulated by MLK-1 (Montrer MAP3K9 Anticorps) MAPK (Montrer MAPK1 Anticorps) kinase kinase (MAPKKK), MEK-1 (Montrer MAP2K1 Anticorps) MAPK (Montrer MAPK1 Anticorps) kinase (MAPKK), and KGB-1 (Montrer KCNJ3 Anticorps) JNK-like MAPK (Montrer MAPK1 Anticorps).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
, JUN kinase
, Jun N-terminal kinase
, Jun NH2-terminal kinase
, Jun-N-terminal kinase
, c-Jun N-terminal kinase
, c-Jun aminoterminal kinase
, c-Jun-N-terminal kinase
, drosophila JNK
, JUN N-terminal kinase
, MAP kinase 8
, c-Jun N-terminal kinase 1
, mitogen-activated protein kinase 8 isoform JNK1 alpha1
, mitogen-activated protein kinase 8 isoform JNK1 beta2
, stress-activated protein kinase 1
, stress-activated protein kinase 1c
, JNK1 beta1 protein kinase
, MAPK 8
, mitogen activated protein kinase 8
, protein kinase mitogen-activated 8
, stress-activated protein kinase JNK1
, SAPK gamma
, c-jun NH2-terminal kinase
, p54 gamma
, mitogen-activated protein kinase 8