Profil protéine

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Alternative names and synonyms associated with MAP2K2

• mitogen-activated protein kinase kinase 2 (MAP2K2) anticorps
• mitogen-activated protein kinase kinase 2 (Map2k2) anticorps
• mitogen activated protein kinase kinase 2 (Map2k2) anticorps
• MAP kinase kinase 2 (MKK2) anticorps
• mitogen-activated protein kinase kinase 2b (map2k2b) anticorps

• AA589381 anticorps
• ATMKK2 anticorps
• CFC4 anticorps
• F27B13.50 anticorps
• F27B13_50 anticorps
• Afficher tous les alias de synonymes
• MAP KINASE KINASE 1 anticorps
• MAP kinase kinase 2 anticorps
• MAPKK2 anticorps
• MEK2 anticorps
• MK1 anticorps
• MK2 anticorps
• MKK2 anticorps
• Prkmk2 anticorps
• zgc:172250 anticorps

Protein level used designations for MAP2K2

ERK activator kinase 2 , MAP kinase kinase 2 , MAPK/ERK kinase 2 , dual specificity mitogen-activated protein kinase kinase 2 , mitogen-activated protein kinase kinase 2, p45 , MAP kinase/Erk kinase , MAPKK 2 , MEK 2 , mitogen activated protein kinase kinase 2 , protein kinase, mitogen activated, kinase 2, p45 , MEK2 , mitogen-activated protein kinase kinase type 2 , dual specificity mitogen activated protein kinase kinase 2