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Report a synthetic lethal interaction of cetuximab in combination with MEK1 (Montrer MAP2K1 Protéines)/2 inhibition for the NRAS (Montrer NRAS Protéines) mutant subgroup of metastatic colorectal cancer.
There are no other biomarkers correlated with treatment responses following MEK1 (Montrer MAP2K1 Protéines)/2 inhibition.
MEK2 was essential for the phosphorylation of MKK3 (Montrer MAP2K3 Protéines)/MKK6 (Montrer MAP2K6 Protéines) and p38 MAPK (Montrer MAPK14 Protéines) that directly impacted on cyclin D1 (Montrer CCND1 Protéines) expression.
High MEK2 expression is associated with inflammation.
there were significant decreases in intercellular adhesion molecules 1 (ICAM1 (Montrer ICAM1 Protéines)), ezrin (EZR (Montrer EZR Protéines)), mitogen-activated protein kinase kinase 2 (MAP2K2), and nitric oxide synthase 3 (NOS3 (Montrer NANOS3 Protéines)) gene expressions in metabolic syndrome patients.
The patient showed a paternally inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving the mitogen-activated protein kinase kinase 2 gene (MAP2K2), in which mutations cause the cardio-facio-cutaneous (CFC (Montrer PTPN11 Protéines)) syndrome
Data show that mitogen-activated protein kinase (Montrer MAPK1 Protéines) kinases MEK1 (Montrer MAP2K1 Protéines)/2 inhibitor pimasertib (MEKI) sensitized the cells to apoptosis through its ability to promote a G1 cell cycle arrest.
the purpose of this paper was to investigate MAPK (Montrer MAPK1 Protéines) downstream signalling molecules in Natural killer cell phenotypes from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.
at clinically relevant concentrations, cDDP binds to and inhibits MEK1 (Montrer MAP2K1 Protéines)/2 and both the binding and inhibitory activity are related to its interaction with Cu bound to MEK1 (Montrer MAP2K1 Protéines)/2
Endocytosis separates EGF (Montrer EGF Protéines) receptors from endogenous fluorescently labeled HRas (Montrer HRAS Protéines) and diminishes receptor signaling to MAP kinases in endosomes.
data suggest that, although short-term suppression of Mek1 (Montrer MAP2K1 Protéines)/2 in ES cells helps to maintain an inner cell mass-like epigenetic state, prolonged suppression results in irreversible changes that compromise their developmental potential
Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC).
fluid shear stress induces autocrine TGF-beta (Montrer TGFB1 Protéines)/ALK5 (Montrer TGFBR1 Protéines)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1 (Montrer MAP2K1 Protéines)/2-mediated signaling.
FGF2 (Montrer FGF2 Protéines) is an extracellular inducer of COUP-TFII (Montrer NR2F2 Protéines) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (Montrer NR2F2 Protéines) expression prior to the onset of osteogenic differentiation
REDD1 (Montrer DDIT4 Protéines) is required for normal insulin (Montrer INS Protéines)-stimulated signaling, and a subtle balance exists between MEK1 (Montrer MAP2K1 Protéines)/2, REDD1 (Montrer DDIT4 Protéines), and mTOR (Montrer FRAP1 Protéines)
MEK1 (Montrer MAP2K1 Protéines) and MEK2 can substitute for each other but a minimum amount of MEK (Montrer MDK Protéines) is critical for placenta development and embryo survival
MK2 (Montrer KCNA2 Protéines)/3 cascade plays a strategic role in controlling synaptic plasticity and cognition.
MK2 (Montrer KCNA2 Protéines) attenuates dendritic cell-mediated Th1 (Montrer HAND1 Protéines) differentiation and autoimmune encephalomyelitis.
analysis of p38 (Montrer CRK Protéines)-MK2 (Montrer KCNA2 Protéines)-activated Rsk (Montrer RPS6KA1 Protéines) signaling in toll (Montrer TLR4 Protéines)-like receptor-stimulated dendritic cells
both MEK1 (Montrer MAP2K1 Protéines) and MEK2 have crucial roles in the integration of mesenchymal and epithelial signals essential for the development of the entire respiratory tract
the AtMKK2-AtMPK10 (Montrer MAPK10 Protéines) MAPK (Montrer MAPK1 Protéines) module regulates leaf venation complexity by altering polar auxin transport efficiency
Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 (Montrer MAPK4 Protéines) activation concomitantly with MEKK1 (Montrer MAP3K1 Protéines) and MKK2 phosphorylation.
Ca(2 (Montrer CA2 Protéines)+) signaling occurred upstream of the MEKK1 (Montrer MAP3K1 Protéines)-MKK2 pathway. MEKK1 (Montrer MAP3K1 Protéines) was phosphorylated by calcium/calmodulin-regulated receptor-like kinase (CRLK1), which suggested that CRLK1 is one of candidates located upstream of MEKK1 (Montrer MAP3K1 Protéines).
Data indicate that MEKK2 (Montrer MAP3K2 Protéines) is required for the mekk1 (Montrer MAP3K1 Protéines), mkk1 (Montrer MAP2K1 Protéines) mkk2, and mpk4 (Montrer MAPK4 Protéines) autoimmune phenotypes.
Data suggest that the MEKK1 (Montrer MAP3K1 Protéines)-MKK1 (Montrer MAP2K1 Protéines)/MKK2-MPK4 (Montrer MAPK4 Protéines) kinase cascade negatively regulates MEKK2 (Montrer MAP3K2 Protéines) and activation of MEKK2 (Montrer MAP3K2 Protéines) triggers SUMM2-mediated immune responses.
Data indicate that MKK2 plays a role in abiotic stress tolerance and plant disease resistance.
double loss-of-function mutant (mkk1 (Montrer MAP2K1 Protéines)/2) of MKK1 (Montrer MAP2K1 Protéines) and MKK2 is shown to have marked phenotypes in development and disease
Activation of MPK4 (Montrer MAPK4 Protéines) by flg22 is impaired in the mkk1 (Montrer MAP2K1 Protéines) mkk2 double mutants, suggesting that MKK1 (Montrer MAP2K1 Protéines) and MKK2 function together with MPK4 (Montrer MAPK4 Protéines) and MEKK1 (Montrer MAP3K1 Protéines) in a MAP kinase (Montrer MAPK1 Protéines) cascade to negatively regulate innate immune responses in plants.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
ERK activator kinase 2
, MAP kinase kinase 2
, MAPK/ERK kinase 2
, MAPKK 2
, MEK 2
, dual specificity mitogen-activated protein kinase kinase 2
, mitogen-activated protein kinase kinase 2, p45
, MAP kinase/Erk kinase
, mitogen activated protein kinase kinase 2
, protein kinase, mitogen activated, kinase 2, p45
, dual specificity mitogen activated protein kinase kinase 2
, mitogen-activated protein kinase kinase type 2