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anti-Rat (Rattus) MAP2K3 Anticorps:
anti-Human MAP2K3 Anticorps:
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Human MAP2K3 Primary Antibody pour IHC - ABIN966578
Wang, Chen, Liao, Deng, Zhou, Huang, Sun: Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. dans Molecular and cellular biology 2002
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Human Polyclonal MAP2K3 Primary Antibody pour IHC - ABIN966579
Raingeaud, Whitmarsh, Barrett, Dérijard, Davis: MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. dans Molecular and cellular biology 1996
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Human Polyclonal MAP2K3 Primary Antibody pour ICC, IHC (p) - ABIN966513
Rampoldi, Zimbello, Bortoluzzi, Tiso, Valle, Lanfranchi, Danieli: Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5. dans Cytogenetics and cell genetics 1998
The study identifies MKK3 as a negative regulator of mitochondrial function and inflammatory responses to cigarette smoke and suggests that MKK3 could be a therapeutic target.
MEK2 (Montrer MAP2K2 Anticorps) was essential for the phosphorylation of MKK3/MKK6 (Montrer MAP2K6 Anticorps) and p38 MAPK (Montrer MAPK14 Anticorps) that directly impacted on cyclin D1 (Montrer CCND1 Anticorps) expression.
High MKK3 expression is associated with lung cancer.
The results revealed upregulation of MEK3, as well as phosphorylated MEK3 and phosphorylated p38 MAPK (Montrer MAPK14 Anticorps), in CMM patients. These results provide a "fingerprint" for mechanistic studies of CMM in the future and highlight the importance of MEK3-p38 MAPK (Montrer MAPK14 Anticorps) activation in CMM.
miR (Montrer MLXIP Anticorps)-21 targets MKK3 in vivo and in vitro, inhibiting the downstream factors IL-6 (Montrer IL6 Anticorps) and TNF-alpha (Montrer TNF Anticorps), in ischemia pretreatment protection from ischemia-reperfusion induced kidney injury.
MKK3 overexpression upregulated the cyclin-dependent kinase (Montrer CDK1 Anticorps) inhibitors, p16 INK4A and p15 INK4B (Montrer CDKN2B Anticorps) in hepatocellular carcinoma cells was Bim1, was downregulated following MKK3 overexpression.
Our results suggest that asthma is associated with MKK3 over-expression in CD8 (Montrer CD8A Anticorps)+ cells; we have also demonstrated that MKK3 may be critical for airway neutrophilia
MicroRNA-21 promotes hepatocellular carcinoma HepG2 cell proliferation through repression of mitogen-activated protein kinase-kinase 3.
study detected higher MKK3 activation in isolated peripheral blood mononuclear cells from septic patients compared with nonseptic controls
study concludes MAP2K3 is a reproducible obesity locus that may affect body weight via complex mechanisms involving appetite regulation and hypothalamic inflammation
The study identifies MKK3 as a negative regulator of mitochondrial function and inflammatory responses to cigarette smoke.
MAP2K6 (Montrer MAP2K6 Anticorps) functions in mouse testis determination, via positive effects on Sry (Montrer SRY Anticorps), and a minor role for MAP2K3.
ATF3 (Montrer ATF3 Anticorps) upregulation in cardiac fibroblasts in response to hypertensive stimuli protects the heart by suppressing Map2K3 expression and subsequent p38 (Montrer CRK Anticorps)-transforming growth factor-beta signaling.
miR (Montrer MLXIP Anticorps)-21a-5p inhibited BPA (Montrer DST Anticorps) induced adipocyte differentiation by targeting map2k3 through MKK3/p38/MAPK (Montrer MAPK14 Anticorps) in 3T3-L1 cells
this study demonstrates that MKK3 influences mitochondrial quality by affecting the expression of mitochondrial proteins, including TCA cycle enzymes, and mitophagy, which consequently regulates the inflammatory response.
Exendin-4 treatment improves cardiac function, attenuates cardiac remodeling, and promotes angiogenesis in the infarcted myocardium through MKK3 and Akt-1 (Montrer AKT1 Anticorps) pathway.
MKK3 and MKK6 (Montrer MAP2K6 Anticorps) differentially regulate bone loss due to estrogen withdrawal. MKK3 directly mediates osteoclastogenesis while MKK6 (Montrer MAP2K6 Anticorps) likely contributes to pro-inflammatory cytokine production that promotes osteoclast formation.
results designate MKK3 as a novel, positive regulator of SCF (Montrer KITLG Anticorps)-induced mast cell proliferation and a critical signaling protein for AP-1 (Montrer JUN Anticorps)-dependent IL-6 (Montrer IL6 Anticorps) production
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
MAP kinase kinase 3
, MAPK/ERK kinase 3
, MAPKK 3
, MEK 3
, SAPK kinase 2
, dual specificity mitogen-activated protein kinase kinase 3
, stress-activated protein kinase kinase 2
, mitogen activated protein kinase kinase 3
, protein kinase, mitogen-activated, kinase 3
, MAP kinase kinase 6
, MAPKK 6
, dual specificity mitogen-activated protein kinase kinase 6
, mitogen-activated protein kinase kinase 3