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This study demonstrates that MKK4 employs a subtle combination of interaction modes in order to bind to p38 alpha (Montrer MAPK14 Protéines), leading to a complex displaying significantly different dynamics across the bound regions.
MKK4 overexpression enhanced TNF-alpha (Montrer TNF Protéines)-mediated signaling activation and transcription of downstream catabolic genes, and consequently worsened cartilage degradation.
Study provides evidence that phosphorylated MKK4 (pMKK4) might function as a tumor suppressor in colorectal cancer (CRC (Montrer CALR Protéines)). Downregulation of pMKK4 was associated with a more aggressive phenotype and with increases in local invasion and metastasis. pMKK4 was also strongly associated with disease-free survival.
Androgen-induced miR (Montrer MLXIP Protéines)-27A acted as a tumor suppressor by targeting MAP2K4 and mediated prostate cancer progression
the expression level of MAP2K4 was inversely associated with the expression of miR (Montrer MLXIP Protéines)-802 in tongue squamous cell carcinoma (TSCC) tissues; demonstration that the MAP2K4 expression was upregulated in TSCC cell lines; elevated expression of miR (Montrer MLXIP Protéines)-802 inhibited TSCC cell viability and invasion through inhibiting MAP2K4 expression
MKK4 activates non-canonical NFkappaB (Montrer NFKB1 Protéines) signaling by promoting NFkappaB2-p100 (Montrer CUX1 Protéines) processing.
Manipulating the expression of both miR (Montrer MLXIP Protéines)-222 and miR (Montrer MLXIP Protéines)-25 influenced diverse gene expression changes in thyroid cells. Increased expression of miR (Montrer MLXIP Protéines)-25 reduced MEK4 and TRAIL protein expression, and cell adhesion and apoptosis are important aspects of miR (Montrer MLXIP Protéines)-25 functioning in thyroid cells.
These results suggest that ROCK may be important in IL-1 (Montrer IL1A Protéines)-induced signaling through MKK4 to JNK (Montrer MAPK8 Protéines) and the activation of p38 MAPK (Montrer MAPK14 Protéines).
Association between MKK4 promoter polymorphism and breast cancer risk in Kashmiri population
In Chinese Han ischemic stroke patients rs3826392 C/A genotype carriers showed significantly higher IL-1b (Montrer IL1B Protéines) serum levels.
MKK4 is the major MAP2K, which activates JNK (Montrer MAPK8 Protéines) in acute liver injury. p38 (Montrer CRK Protéines), the other downstream target of MKK4, does not contribute to liver injury from APAP or TNF (Montrer TNF Protéines)/galactosamine.
MKK4 activates non-canonical NFkappaB signaling by promoting NFkappaB2-p100 (Montrer PATL2 Protéines) processing.
Demonstrate that Mkk4 is a negative regulator of the TGF-beta1 (Montrer TGFB1 Protéines) signaling associated with atrial remodeling and arrhythmogenesis with age.
This study provides compelling evidence for the pivotal roles of the ZPK/DLK (Montrer MAP3K12 Protéines) and MKK4/MAP2K4-dependent mechanism in axotomy-induced motoneuron death in neonates.
The loss of mkk4 and mkk7 (Montrer MAP2K7 Protéines) locks damaged exocrine cells in a permanently de-differentiated state.
Studies identify the dual-specific kinase MKK4 as a master regulator of liver regeneration. MKK4 silencing robustly increased the regenerative capacity of hepatocytes in mouse models of liver regeneration and acute and chronic liver failure.
MicroRNA-92a negatively regulates Toll (Montrer TLR4 Protéines)-like receptor (TLR)-triggered inflammatory response in macrophages by targeting MKK4 kinase
Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation.
MKK4/7 and JNK1 (Montrer MAPK8 Protéines)/2 played regulatory role in cytoskeleton reorganization during vaccinia virus infection.
These data support a model in which MKK4 activation at the metastatic site causes a cell-cycle arrest.
in Drosophila both MAPKKs, Hep/Mkk7 (Montrer MAP2K7 Protéines) and Mkk4, are required to induce JNK (Montrer MAPK8 Protéines) upon TNF (Montrer TNF Protéines) or pro-inflammatory stimulation
The Arabidopsis MKK4/MKK5 (Montrer MAP2K5 Protéines)-MPK6 (Montrer MAPK6 Protéines) cascade is an important player in the maternal control of embryogenesis.
MKK4, MKK5 (Montrer MAP2K5 Protéines), MKK7 (Montrer MAP2K7 Protéines), and MKK9, are responsible for the activation of MPK3 (Montrer MAPK3 Protéines) and MPK6 (Montrer MAPK6 Protéines) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (Montrer MAPK1 Protéines) signaling through MKK4/5/7/9-MPK3 (Montrer MAPK3 Protéines)/6 cascades.
our data indicate that EDR1 physically associates with MKK4/MKK5 (Montrer MAP2K5 Protéines) and negatively regulates the MAPK (Montrer MAPK1 Protéines) cascade to fine-tune plant innate immunity.
Results suggest that the YDA-MKK4/MKK5 (Montrer MAP2K5 Protéines)-MPK3 (Montrer MAPK3 Protéines)/MPK6 (Montrer MAPK6 Protéines) cascade functions downstream of the ER receptor in regulating localized cell proliferation, which further shapes the morphology of plant organs.
MKK4 is involved in the osmotic-stress response via its regulation of MPK3 (Montrer MAPK3 Protéines) activity.
MKK4 is a key regulator of stomatal development and patterning.
This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.
JNK activating kinase 1
, JNK-activated kinase 1
, JNK-activating kinase 1
, MAP kinase kinase 4
, MAPK/ERK kinase 4
, MAPKK 4
, MEK 4
, SAPK/ERK kinase 1
, c-Jun N-terminal kinase kinase 1
, dual specificity mitogen-activated protein kinase kinase 4
, stress-activated protein kinase kinase 1
, C-JUN N-terminal kinase kinase 1
, JNK kinase 1
, JNKK 1
, SAPK/Erk/kinase 1
, mitogen activated protein kinase kinase 4, variant 1
, mitogen-activated protein kinase kinase 4
, JNK kinase 2
, Map kinase kinase 4
, drosophila MAP kinase kinase 4