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anti-Rat (Rattus) MAP2K5 Anticorps:
anti-Human MAP2K5 Anticorps:
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Dog (Canine) Monoclonal MAP2K5 Primary Antibody pour IF, WB - ABIN968273
English, Vanderbilt, Xu, Marcus, Cobb: Isolation of MEK5 and differential expression of alternatively spliced forms. dans The Journal of biological chemistry 1996
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Human Monoclonal MAP2K5 Primary Antibody pour IF, WB - ABIN968272
Zhou, Bao, Dixon: Components of a new human protein kinase signal transduction pathway. dans The Journal of biological chemistry 1995
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Human Polyclonal MAP2K5 Primary Antibody pour IF (p), IHC (p) - ABIN754183
Chen, Hou, Ye, Chen, Cui, Tian, Li, Liu: MicroRNA-143 regulates adipogenesis by modulating the MAP2K5-ERK5 signaling. dans Scientific reports 2014
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Chicken Polyclonal MAP2K5 Primary Antibody pour WB - ABIN2475554
Cameron, Abe, Malik, Che, Yang: Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation. dans The Journal of biological chemistry 2004
For gain and loss of function studies, constitutively active MEK5 (CA-MEK5) and ERK5 (Montrer MAPK7 Anticorps) shRNA lentiviruses were used to activate or knock down extracellular signal-regulated kinase 5 (ERK5 (Montrer MAPK7 Anticorps)). Our results confirmed that low concentrations of H2O2 promoted HUVECs angiogenesis in vitro, and ERK5 (Montrer MAPK7 Anticorps) is an essential mediator of this process. Therefore, ERK5 (Montrer MAPK7 Anticorps) may be a potential therapeutic target for promoting angiogenesis
results confirmed the association of BTBD9 (Montrer BTBD9 Anticorps) and MAP2K5/SKOR1 (Montrer SKOR1 Anticorps) with primary Restless Legs Syndrome in Chinese population
Results revealed the expression of MEK5 was higher in tumor tissues and provide evidence that MEK5 plays an important role in colorectal cancer progression.
Insights into a molecular mechanism by which MEK5 transcriptionally upregulated by Stat3 (Montrer STAT3 Anticorps) augments breast cancer cell EMT (Montrer ITK Anticorps), which subsequently enhances cancer cell invasion and metastasis. This finding may suggest that Stat3 (Montrer STAT3 Anticorps) and MEK5/Erk5 (Montrer MAPK7 Anticorps) pathways could be an effective therapeutic target for inhibition of breast cancer invasion and metastasis.
Our findings confirm an association between the BTBD9 (Montrer BTBD9 Anticorps), MEIS1 (Montrer MEIS1 Anticorps), and MAP2K5/SKOR1 (Montrer SKOR1 Anticorps) SNPs and periodic limb movements of sleep in an elderly cohort.
Specifically, CKS1B (Montrer CKS1B Anticorps) and MAP2K5 significantly inhibited hepatitis C viral RNA replication. PACSIN1 (Montrer PACSIN1 Anticorps), by contrast, inhibited hepatitis C virus infection by decreasing the level of viral protein p7.
High MEK5 expression is associated with colorectal cancer.
SEC16B, MC4R, MAP2K5 and KCTD15 (rs17782313, rs543874, rs2241423 and rs11084753) polymorphisms are associated with the risk for children obesity in China.
Periodic leg movements during sleep are associated with polymorphisms in BTBD9 (Montrer BTBD9 Anticorps), TOX3 (Montrer TOX3 Anticorps)/BC034767, MEIS1 (Montrer MEIS1 Anticorps), MAP2K5/SKOR1 (Montrer SKOR1 Anticorps), and PTPRD (Montrer PTPRD Anticorps)
Inhibitors of apoptosis proteins regulate myogenic differentiation by directly suppressing MEKK2 (Montrer MAP3K2 Anticorps)/3-MEK5-ERK5 (Montrer MAPK7 Anticorps) signaling.
These results suggest that YAP (Montrer YAP1 Anticorps) promotes muscle differentiation by activating the Abl (Montrer ABL1 Anticorps)/Src (Montrer SRC Anticorps)/MEKK3 (Montrer MAP3K3 Anticorps)/MEK5/ERK5 (Montrer MAPK7 Anticorps) kinase cascade.
MEK5 overexpression inhibits differentiation of osteoblasts.
the MEK5-ERK5 (Montrer MAPK7 Anticorps) MAP kinase (Montrer MAPK1 Anticorps) signaling pathway has a critical role in BAFF (Montrer TNFSF13B Anticorps)-induced mature B cell survival and homeostatic maintenance of B2 cell numbers
The MEK5/ERK5 (Montrer MAPK7 Anticorps) pathway also mediates FSS-induced Runx-2 (Montrer RUNX2 Anticorps) expression in osteoblast differentiation.
finding suggested that REST promoted primordial germ cells survival via regulation of the Mek5 expression
PB1 (Montrer GPR97 Anticorps) domain mediates the association of MEKK2 (Montrer MAP3K2 Anticorps) and MEKK3 (Montrer MAP3K3 Anticorps) with MEK5 and that the respective PB1 (Montrer GPR97 Anticorps) domains of these kinases are critical for regulation of the ERK5 (Montrer MAPK7 Anticorps) pathway.
MEK5 is an activator of ERK5 (Montrer MAPK7 Anticorps) and an essential regulator of cell survival that is required for normal embryonic development
the N terminus of MEK5alpha is critical for the specific organization of the components of the ERK5 (Montrer MAPK7 Anticorps) signaling pathway
MEK5 and big MAP kinase 1 (BMK1 (Montrer MAPK7 Anticorps)) function downstream of MEKK3 (Montrer MAP3K3 Anticorps) in a signaling cascade that induces calcineurin activity through phosphorylation of MCIP1 (Montrer PPP3R1 Anticorps)
A noncanonical function of Map2k5 domain is decribed for coordinated erk5 (Montrer MAPK7 Anticorps) kinase and map2k7 (Montrer MAP2K7 Anticorps) signaling.
results indicated that AIK1-MKK5-MPK6 (Montrer MAPK6 Anticorps) functions in ABA responses and requires ABA-responsive gene expression to regulate ABA-inhibited root growth and cell division. The ABA signaling pathway regulates this MAPK (Montrer MAPK1 Anticorps) cascade.
AIK1-MKK5-MPK6 (Montrer MAPK6 Anticorps) cascade functions in the abscisic acid regulation of primary root growth and stomatal response.
MKK4 (Montrer MAP2K4 Anticorps), MKK5, MKK7 (Montrer MAP2K7 Anticorps), and MKK9, are responsible for the activation of MPK3 (Montrer MAPK3 Anticorps) and MPK6 (Montrer MAPK6 Anticorps) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (Montrer MAPK1 Anticorps) signaling through MKK4 (Montrer MAP2K4 Anticorps)/5/7/9-MPK3 (Montrer MAPK3 Anticorps)/6 cascades.
Overexpression of MKK5 in wild-type plants enhanced their tolerance to salt treatments. Another kinase, MPK6 (Montrer MAPK6 Anticorps), was also involved in the MKK5-mediated iron superoxide dismutase (FSD) signalling pathway in salt stress.
our data indicate that EDR1 (Montrer PHC1 Anticorps) physically associates with MKK4 (Montrer MAP2K4 Anticorps)/MKK5 and negatively regulates the MAPK (Montrer MAPK1 Anticorps) cascade to fine-tune plant innate immunity.
Data indicate that in the MKK5-RNAi (RNA interference) lines, the induction of CSD1 and CSD2 (Montrer TGFB1 Anticorps) as well as the activation of MKK5 activity were completely arrested.
Results suggest that the YDA-MKK4 (Montrer MAP2K4 Anticorps)/MKK5-MPK3 (Montrer MAPK3 Anticorps)/MPK6 (Montrer MAPK6 Anticorps) cascade functions downstream of the ER receptor in regulating localized cell proliferation, which further shapes the morphology of plant organs.
MKK5 functions both in ozone-induced activation of MPK3 (Montrer MAPK3 Anticorps) and MPK6 (Montrer MAPK6 Anticorps) and in integrating reactive oxygen species homeostasis during ozone stress.
MKK5 is a key regulator of stomatal development and patterning.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
MAP kinase kinase 5
, MAPK/ERK kinase 5
, MAPKK 5
, MEK 5
, dual specificity mitogen-activated protein kinase kinase 5
, mitogen-activated protein kinase kinase 5
, MAP kinase kinase MEK5b
, MAPK/ERK kinese 5
, mitogen activated protein kinase kinase 5