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Human MAP2K5 Protein expressed in Wheat germ - ABIN1310183
García-Hoz, Sánchez-Fernández, Díaz-Meco, Moscat, Mayor, Ribas: G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR). dans The Journal of biological chemistry 2010
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The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
MAP kinase kinase 5
, MAPK/ERK kinase 5
, MAPKK 5
, MEK 5
, dual specificity mitogen-activated protein kinase kinase 5
, mitogen-activated protein kinase kinase 5
, MAP kinase kinase MEK5b
, MAPK/ERK kinese 5
, mitogen activated protein kinase kinase 5