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Human MAP2K5 Protein expressed in Wheat germ - ABIN1310183
García-Hoz, Sánchez-Fernández, Díaz-Meco, Moscat, Mayor, Ribas: G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR). dans The Journal of biological chemistry 2010
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results confirmed the association of BTBD9 and MAP2K5/SKOR1 with primary Restless Legs Syndrome in Chinese population
Results revealed the expression of MEK5 was higher in tumor tissues and provide evidence that MEK5 plays an important role in colorectal cancer progression.
Insights into a molecular mechanism by which MEK5 transcriptionally upregulated by Stat3 (Montrer STAT3 Protéines) augments breast cancer cell EMT (Montrer ITK Protéines), which subsequently enhances cancer cell invasion and metastasis. This finding may suggest that Stat3 (Montrer STAT3 Protéines) and MEK5/Erk5 (Montrer MAPK7 Protéines) pathways could be an effective therapeutic target for inhibition of breast cancer invasion and metastasis.
Our findings confirm an association between the BTBD9, MEIS1, and MAP2K5/SKOR1 SNPs and periodic limb movements of sleep in an elderly cohort.
Specifically, CKS1B (Montrer CKS1B Protéines) and MAP2K5 significantly inhibited hepatitis C viral RNA replication. PACSIN1 (Montrer PACSIN1 Protéines), by contrast, inhibited hepatitis C virus infection by decreasing the level of viral protein p7.
High MEK5 expression is associated with colorectal cancer.
SEC16B, MC4R, MAP2K5 and KCTD15 (rs17782313, rs543874, rs2241423 and rs11084753) polymorphisms are associated with the risk for children obesity in China.
Periodic leg movements during sleep are associated with polymorphisms in BTBD9 (Montrer BTBD9 Protéines), TOX3 (Montrer TOX3 Protéines)/BC034767, MEIS1 (Montrer MEIS1 Protéines), MAP2K5/SKOR1, and PTPRD (Montrer PTPRD Protéines)
Inhibitors of apoptosis proteins regulate myogenic differentiation by directly suppressing MEKK2 (Montrer MAP3K2 Protéines)/3-MEK5-ERK5 (Montrer MAPK7 Protéines) signaling.
MiR (Montrer MLXIP Protéines)-330-3p and MAP2K5 are potentially important contributors to mood and anxiety-related traits
These results suggest that YAP (Montrer YAP1 Protéines) promotes muscle differentiation by activating the Abl (Montrer ABL1 Protéines)/Src (Montrer SRC Protéines)/MEKK3 (Montrer MAP3K3 Protéines)/MEK5/ERK5 (Montrer MAPK7 Protéines) kinase cascade.
MEK5 overexpression inhibits differentiation of osteoblasts.
the MEK5-ERK5 (Montrer MAPK7 Protéines) MAP kinase (Montrer MAPK1 Protéines) signaling pathway has a critical role in BAFF (Montrer TNFSF13B Protéines)-induced mature B cell survival and homeostatic maintenance of B2 cell numbers
The MEK5/ERK5 (Montrer MAPK7 Protéines) pathway also mediates FSS-induced Runx-2 (Montrer RUNX2 Protéines) expression in osteoblast differentiation.
finding suggested that REST promoted primordial germ cells survival via regulation of the Mek5 expression
PB1 (Montrer GPR97 Protéines) domain mediates the association of MEKK2 (Montrer MAP3K2 Protéines) and MEKK3 (Montrer MAP3K3 Protéines) with MEK5 and that the respective PB1 (Montrer GPR97 Protéines) domains of these kinases are critical for regulation of the ERK5 (Montrer MAPK7 Protéines) pathway.
MEK5 is an activator of ERK5 (Montrer MAPK7 Protéines) and an essential regulator of cell survival that is required for normal embryonic development
the N terminus of MEK5alpha is critical for the specific organization of the components of the ERK5 (Montrer MAPK7 Protéines) signaling pathway
MEK5 and big MAP kinase 1 (BMK1 (Montrer MAPK7 Protéines)) function downstream of MEKK3 (Montrer MAP3K3 Protéines) in a signaling cascade that induces calcineurin activity through phosphorylation of MCIP1 (Montrer PPP3R1 Protéines)
A noncanonical function of Map2k5 domain is decribed for coordinated erk5 (Montrer MAPK7 Protéines) kinase and map2k7 (Montrer MAP2K7 Protéines) signaling.
results indicated that AIK1-MKK5-MPK6 (Montrer MAPK6 Protéines) functions in ABA responses and requires ABA-responsive gene expression to regulate ABA-inhibited root growth and cell division. The ABA signaling pathway regulates this MAPK (Montrer MAPK1 Protéines) cascade.
AIK1-MKK5-MPK6 (Montrer MAPK6 Protéines) cascade functions in the abscisic acid regulation of primary root growth and stomatal response.
MKK4 (Montrer MAP2K4 Protéines), MKK5, MKK7 (Montrer MAP2K7 Protéines), and MKK9, are responsible for the activation of MPK3 (Montrer MAPK3 Protéines) and MPK6 (Montrer MAPK6 Protéines) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (Montrer MAPK1 Protéines) signaling through MKK4 (Montrer MAP2K4 Protéines)/5/7/9-MPK3 (Montrer MAPK3 Protéines)/6 cascades.
Overexpression of MKK5 in wild-type plants enhanced their tolerance to salt treatments. Another kinase, MPK6 (Montrer MAPK6 Protéines), was also involved in the MKK5-mediated iron superoxide dismutase (FSD) signalling pathway in salt stress.
our data indicate that EDR1 physically associates with MKK4 (Montrer MAP2K4 Protéines)/MKK5 and negatively regulates the MAPK (Montrer MAPK1 Protéines) cascade to fine-tune plant innate immunity.
Data indicate that in the MKK5-RNAi (RNA interference) lines, the induction of CSD1 and CSD2 (Montrer TGFB1 Protéines) as well as the activation of MKK5 activity were completely arrested.
Results suggest that the YDA-MKK4 (Montrer MAP2K4 Protéines)/MKK5-MPK3 (Montrer MAPK3 Protéines)/MPK6 (Montrer MAPK6 Protéines) cascade functions downstream of the ER receptor in regulating localized cell proliferation, which further shapes the morphology of plant organs.
MKK5 functions both in ozone-induced activation of MPK3 (Montrer MAPK3 Protéines) and MPK6 (Montrer MAPK6 Protéines) and in integrating reactive oxygen species homeostasis during ozone stress.
MKK5 is a key regulator of stomatal development and patterning.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
MAP kinase kinase 5
, MAPK/ERK kinase 5
, MAPKK 5
, MEK 5
, dual specificity mitogen-activated protein kinase kinase 5
, mitogen-activated protein kinase kinase 5
, MAP kinase kinase MEK5b
, MAPK/ERK kinese 5
, mitogen activated protein kinase kinase 5