anti-Humain MAP2K6 anticorps pour Immunofluorescence (Paraffin-embedded Sections)

Recommended MAP2K6 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) Anticorps
  • MAPKK6
  • MEK6
  • MKK6
  • PRKMK6
  • SAPKK-3
  • SAPKK3
  • Mkk6
  • Prkmk6
  • ANQ1
  • ARABIDOPSIS NQK1
  • ARABIDOPSIS THALIANA MAP KINASE KINASE 6
  • ATMKK6
  • MAP kinase kinase 6
  • MIK19.2
  • MIK19_2
  • MKK3
  • map2k3
  • zMKK3
  • mitogen-activated protein kinase kinase 6
  • MAP kinase kinase 6
  • MAP2K6
  • Map2k6
  • MKK6
  • map2k6
Reactivité
Humain, Souris, Rat (Rattus)
193
131
96
5
4
4
2
2
1
1
1
1
1
1
1
Hôte
Lapin
171
44
2
Clonalité
Polyclonal
Conjugué
Cet anticorp MAP2K6 est non-conjugé
5
5
5
3
3
3
2
2
2
2
2
2
2
2
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
178
78
73
42
37
26
16
15
11
7
3
2
1
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N° du produit ABIN681568
$ 306.90
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
1 ABIN743903 IF (p) IHC (p) WB Rabbit IgG pSer202 Connectez-vous pour afficher Polyclonal
1 ABIN743892 IF (p) Cy5 Rabbit IgG pSer207 Connectez-vous pour afficher Polyclonal
1 ABIN743891 IF (p) Cy3 Rabbit IgG pSer207 Connectez-vous pour afficher Polyclonal
1 ABIN743893 IF (p) Cy5.5 Rabbit IgG pSer207 Connectez-vous pour afficher Polyclonal
1 ABIN743894 IF (p) Cy7 Rabbit IgG pSer207 Connectez-vous pour afficher Polyclonal
1 ABIN743895 IF (p) FITC Rabbit IgG pSer207 Connectez-vous pour afficher Polyclonal
1 ABIN681571 IF (p) Cy3 Rabbit IgG Connectez-vous pour afficher Polyclonal
1 ABIN681572 IF (p) Cy5 Rabbit IgG Connectez-vous pour afficher Polyclonal
1 ABIN681573 IF (p) Cy5.5 Rabbit IgG Connectez-vous pour afficher Polyclonal
1 ABIN681574 IF (p) Cy7 Rabbit IgG Connectez-vous pour afficher Polyclonal
1 ABIN681575 IF (p) FITC Rabbit IgG Connectez-vous pour afficher Polyclonal
1 ABIN906112 IF (p) Alexa Fluor 488 Rabbit IgG Connectez-vous pour afficher Polyclonal
1 ABIN906113 IF (p) Alexa Fluor 555 Rabbit IgG Connectez-vous pour afficher Polyclonal
1 ABIN906114 IF (p) Alexa Fluor 350 Rabbit IgG Connectez-vous pour afficher Polyclonal
1 ABIN906115 IF (p) Alexa Fluor 647 Rabbit IgG Connectez-vous pour afficher Polyclonal
1 ABIN874786 IF (p) Alexa Fluor 488 Rabbit IgG pSer207 Connectez-vous pour afficher Polyclonal
1 ABIN874787 IF (p) Alexa Fluor 555 Rabbit IgG pSer207 Connectez-vous pour afficher Polyclonal
1 ABIN874788 IF (p) Alexa Fluor 647 Rabbit IgG pSer207 Connectez-vous pour afficher Polyclonal
1 ABIN874790 IF (p) Alexa Fluor 350 Rabbit IgG pSer207 Connectez-vous pour afficher Polyclonal
1 ABIN2804135 IF (p) Alexa Fluor 594 Rabbit IgG Connectez-vous pour afficher Polyclonal

General

Antigène Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) Anticorps
Reactivité Humain, Souris, Rat (Rattus)
(193), (131), (96), (5), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Hôte Lapin
(171), (44), (2)
Clonalité
Polyclonal
Conjugué Cet anticorp MAP2K6 est non-conjugé
(5), (5), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(178), (78), (73), (42), (37), (26), (16), (15), (11), (7), (3), (2), (1)
Pubmed 1 référence disponible
Fournisseur Connectez-vous pour afficher

Détail du produit anti-MAP2K6 anticorps

Détail du antigène MAP2K6 Information d'application Stockage References for anti-MAP2K6 antibody (ABIN681568) Images
Purification Purified by Protein A.
Immunogène KLH conjugated synthetic peptide derived from human MEK6
Isotype IgG

Détail du antigène MAP2K6

Détail du produit anti-MAP2K6 anticorps Information d'application Stockage References for anti-MAP2K6 antibody (ABIN681568) Images Haut de la page
Antigène
Autre désignation Mek6 (MAP2K6 Antibody Extrait)
Sujet

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction, and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.

Subcellular location: Cytoplasm, Nucleus

Synonyms: MEK6, MKK6, MAPKK6, PRKMK6, SAPKK3, SAPKK-3, Dual specificity mitogen-activated protein kinase kinase 6, MAP kinase kinase 6, MAPKK 6, MAPK/ERK kinase 6, MEK 6, Stress-activated protein kinase kinase 3, SAPK kinase 3, MAP2K6, SKK3

ID gène 5608
UniProt P52564
Domaine de recherche Immunology, Innate Immunity, Tyrosine Kinases, Kinases/Phosphatases
Pathways Signalisation MAPK, Signalisation TLR, Activation of Innate immune Response, Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades

Information d'application

Détail du produit anti-MAP2K6 anticorps Détail du antigène MAP2K6 Stockage References for anti-MAP2K6 antibody (ABIN681568) Images Haut de la page
Indications d'application WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Stockage

Détail du produit anti-MAP2K6 anticorps Détail du antigène MAP2K6 Information d'application References for anti-MAP2K6 antibody (ABIN681568) Images Haut de la page
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months

References for anti-MAP2K6 antibody (ABIN681568)

Détail du produit anti-MAP2K6 anticorps Détail du antigène MAP2K6 Information d'application Stockage Images Haut de la page
Produit citée dans:

Shi, Zhan, Zhao, Wang, Ma: "Effects of Fluoride on the Expression of p38MAPK Signaling Pathway-Related Genes and Proteins in Spleen Lymphocytes of Mice." dans: Biological trace element research, Vol. 173, Issue 2, pp. 333-8, 2016