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anti-Rat (Rattus) MAP2K7 Anticorps:
anti-Human MAP2K7 Anticorps:
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Human Monoclonal MAP2K7 Primary Antibody pour ICC, FACS - ABIN969271
Yoshizawa, Hammaker, Sweeney, Boyle, Firestein: Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases. dans Journal of immunology (Baltimore, Md. : 1950) 2008
Show all 2 Pubmed References
In the coBRIM phase III trial, the addition of cobimetinib, an MEK (Montrer MAP2K1 Anticorps) inhibitor, to vemurafenib, a BRAF (Montrer BRAF Anticorps) inhibitor, significantly improved progression-free survival [hazard ratio (HR), 0.58; P < 0.0001] and overall survival (HR, 0.70; P = 0.005) in advanced BRAF (Montrer BRAF Anticorps)-mutated melanoma. Here, we report on the incidence, course, and management of key adverse events (AEs (Montrer AES Anticorps)) in the coBRIM study
the p.Glu116Lys rare variant in MAP2K7 predisposes its carriers to develop COPD (Montrer ARCN1 Anticorps), which would provide a useful genetic biomarker for COPD (Montrer ARCN1 Anticorps) susceptibility in Chinese.
Combination BRAF (Montrer BRAF Anticorps) and MEK (Montrer MAP2K1 Anticorps) inhibition has also been shown to improve overall survival in patients with V600E-mutated melanoma. Responses to therapy are often rapid, and treatment is not associated with immune-related adverse events.
Our findings indicate that GADD45 (Montrer GADD45A Anticorps) essentially suppresses the MKK7-JNK (Montrer MAPK8 Anticorps) pathway and suggest that differentially expressed GADD45 (Montrer GADD45A Anticorps) family members fine-tune stress-inducible JNK (Montrer MAPK8 Anticorps) activity.
The latter insight is likely to promote the production of allosteric MAP2K7 inhibitors.
MEK activation cooperates with Cdkn2a and Pten inactivation to induce melanoma
MKK7 undergoes neddylation in human breast cancer cells
In an Eastern Chinese population, carriers of MAP2K7 rs3679T variant genotypes had an increased risk of NSCLC.
Therefore, EGF (Montrer EGF Anticorps) is suggested to induce E-cadherin (Montrer CDH1 Anticorps) down-regulation at the transcriptional level through the MEK (Montrer MAP2K1 Anticorps)/ERK (Montrer EPHB2 Anticorps) pathway, which might result in, at least in part, the induction of cellular morphological changes and cell migration in LoVo cells.
combined pan-RAF and MEK inhibition can overcome intrinsic and acquired resistance to single-agent RAF/MEK inhibition, supporting dual pan-RAF and MEK inhibition as a novel therapeutic strategy for BRAF- and KRAS-mutant cancers
High Map2k7 expression is associated with T-cell acute lymphoblastic leukemia.
The loss of mkk4 (Montrer MAP2K4 Anticorps) and mkk7 locks damaged exocrine cells in a permanently de-differentiated state.
Arrestin-3 (Montrer ARRB2 Anticorps) directly interacts with MKK7 and promotes JNK3alpha2 phosphorylation by both MKK4 (Montrer MAP2K4 Anticorps) and MKK7 in vitro as well as in intact cells.
MKK7 is specifically phosphorylated in the neurite shaft which triggers Map1b (Montrer MAP1B Anticorps) phosphorylation to regulate microtubule bundling leading to neurite elongation.
Data indicate that mitogen activated protein kinase kinase 7 (MKK7) plays a critical regulatory role in the c-Jun N-terminal kinase pathway in a murine model of rheumatoid arthritis.
a novel function for the stress kinase MKK7 as a regulator of the circadian clock in mammalian cells at steady state.
Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation.
MKK4 (Montrer MAP2K4 Anticorps)/7 and JNK1 (Montrer MAPK8 Anticorps)/2 played regulatory role in cytoskeleton reorganization during vaccinia virus infection.
This study demonistrated that Stress-activated protein kinase (Montrer CDK7 Anticorps) MKK7 regulates axon elongation in the developing cerebral cortex.
The results reveal an essential role of MKK7 in cardiomyocytes for protecting the heart from hypertrophic insults thereby preventing the transition to heart failure.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
mitogen-activated protein kinase kinase 7
, JNK kinase 2
, JNK-activating kinase 2
, JNKK 2
, MAP kinase kinase 7
, MAPK/ERK kinase 7
, MAPKK 7
, MEK 7
, c-Jun N-terminal kinase kinase 2
, dual specificity mitogen-activated protein kinase kinase 7
, SAPK kinase 4
, stress-activated protein kinase kinase 4
, mitogen activated protein kinase kinase 7
, protein kinase, mitogen activated, kinase 7