anti-Humain MAP3K12 anticorps pour Enzyme Immunoassay

Recommended MAP3K12 Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) Anticorps
  • DLK
  • MEKK12
  • MUK
  • ZPK
  • ZPKP1
  • PK
  • Zpk
  • zgc:77370
  • MGC151798
  • dlk
  • map3k12
  • map3k12a
  • mekk12
  • muk
  • zpk
  • zpkp1
  • DKFZp459K2433
  • map3k12-a
  • map3k12-b
  • map3k12b
  • mitogen-activated protein kinase kinase kinase 12
  • mitogen activated protein kinase kinase kinase 12
  • mitogen-activated protein kinase kinase kinase 12 S homeolog
  • mitogen-activated protein kinase kinase kinase 12 L homeolog
  • MAP3K12
  • Map3k12
  • map3k12
  • map3k12.S
  • map3k12.L
Épitope
C-Term
13
10
4
4
3
2
1
1
1
Reactivité
Humain, Souris
59
26
15
Hôte
Lapin
50
12
Clonalité
Polyclonal
Conjugué
Cet anticorp MAP3K12 est non-conjugé
7
6
4
3
3
3
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
52
39
31
6
5
3
1
1
Fournisseur
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Images

N° du produit ABIN359408
$ 390.50
Plus shipping costs $45.00

General

Antigène Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) Anticorps
Épitope C-Term
(13), (10), (4), (4), (3), (2), (1), (1), (1)
Reactivité Humain, Souris
(59), (26), (15)
Hôte Lapin
(50), (12)
Clonalité
Polyclonal
Conjugué Cet anticorp MAP3K12 est non-conjugé
(7), (6), (4), (3), (3), (3)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(52), (39), (31), (6), (5), (3), (1), (1)
Pubmed 5 références disponible
Fournisseur Connectez-vous pour afficher

Détail du produit anti-MAP3K12 anticorps

Détail du antigène MAP3K12 Information d'application Stockage References for anti-MAP3K12 antibody (ABIN359408) Images
Specificité This antibody detects MAP3K12 at C-term.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Immunogène This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human ZPK.
Isotype Ig Fraction
Plasmids, Primers & others

Détail du antigène MAP3K12

Détail du produit anti-MAP3K12 anticorps Information d'application Stockage References for anti-MAP3K12 antibody (ABIN359408) Images Haut de la page
Antigène
Autre désignation MAP3K12 (MAP3K12 Antibody Extrait)
Sujet ZPK is a member of serine/threonine protein kinase family. This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation.Synonyms: Dual leucine zipper bearing kinase, Leucine-zipper protein kinase, MAPK-upstream kinase, Mitogen-activated protein kinase kinase kinase 12, Mixed lineage kinase
Poids moléculaire 93188 Da
ID gène 7786, 9606
UniProt Q12852
Pathways Signalisation MAPK

Information d'application

Détail du produit anti-MAP3K12 anticorps Détail du antigène MAP3K12 Stockage References for anti-MAP3K12 antibody (ABIN359408) Images Haut de la page
Indications d'application ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Stockage

Détail du produit anti-MAP3K12 anticorps Détail du antigène MAP3K12 Information d'application References for anti-MAP3K12 antibody (ABIN359408) Images Haut de la page
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock 4 °C/-20 °C
Stockage commentaire Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

References for anti-MAP3K12 antibody (ABIN359408)

Détail du produit anti-MAP3K12 anticorps Détail du antigène MAP3K12 Information d'application Stockage Images Haut de la page
Background publications

Itoh, Wang, Ito, Reddy, Itoh: "SP3 acts as a positive regulator on the core promoter of human ZPK gene." dans: Biochemical and biophysical research communications, Vol. 313, Issue 3, pp. 612-8, 2003

Fukuyama, Yoshida, Yamashita, Deyama, Baba, Suzuki, Mohri, Ikezawa, Nakajima, Hirai, Ohno: "MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper protein kinase." dans: The Journal of biological chemistry, Vol. 275, Issue 28, pp. 21247-54, 2000

Reddy, Basu, Bannerman, Ikegaki, Reddy, Pleasure: "ZPK inhibits PKA induced transcriptional activation by CREB and blocks retinoic acid induced neuronal differentiation." dans: Oncogene, Vol. 18, Issue 31, pp. 4474-84, 1999

Mata, Merritt, Fan, Yu, Holzman: "Characterization of dual leucine zipper-bearing kinase, a mixed lineage kinase present in synaptic terminals whose phosphorylation state is regulated by membrane depolarization via calcineurin." dans: The Journal of biological chemistry, Vol. 271, Issue 28, pp. 16888-96, 1996

Curran: "It is better to travel hopefully ellipsis" dans: Chemistry & biology, Vol. 3, Issue 8, pp. 641-2, 1996

Images

Détail du produit anti-MAP3K12 anticorps Détail du antigène MAP3K12 Information d'application Stockage References for anti-MAP3K12 antibody (ABIN359408) Haut de la page
Images (Fournisseur)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) (C-Term) antibody (ABIN359408) Formalin-fixed and paraffin-embedded human cancer tissue (breast carcinoma) reacted w...
Western Blotting (WB) image for anti-Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) (C-Term) antibody (ABIN359408) Western blot analysis of anti-ZPK C-term Pab in HL-60 cell lysate (lane A) and in mou...