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anti-Human MAPK3 Anticorps:
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Human Polyclonal MAPK3 Primary Antibody pour ICC, IHC (p) - ABIN3044377
Li, Zhu, Liu, Liu, Wang, Xiong, Shen, Hu, Zheng: ZFX knockdown inhibits growth and migration of non-small cell lung carcinoma cell line H1299. dans International journal of clinical and experimental pathology 2013
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Human Polyclonal MAPK3 Primary Antibody pour WB - ABIN1881527
Munshi, Wu, Mukhopadhyay, Ottaviano, Sassano, Koblinski, Platanias, Stack et al.: Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth ... dans The Journal of biological chemistry 2004
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Chicken Polyclonal MAPK3 Primary Antibody pour ICC, FACS - ABIN361833
Boulton, Gregory, Cobb: Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase. dans Biochemistry 1991
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Chicken Monoclonal MAPK3 Primary Antibody pour IF, IP - ABIN967952
Boulton, Cobb: Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. dans Cell regulation 1991
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Human Polyclonal MAPK3 Primary Antibody pour IF (p), IHC (p) - ABIN744143
Zhao, Zhang, Liu, Zhang, Hao, Li, Chen, Shen, Tang, Min, Meng, Wang, Yi, Zhang: Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways. dans Scientific reports 2016
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Human Polyclonal MAPK3 Primary Antibody pour WB - ABIN2801963
McLaughlin, Kumar, McDonnell, Van Horn, Lee, Livi, Young: Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. dans The Journal of biological chemistry 1996
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Mouse (Murine) Polyclonal MAPK3 Primary Antibody pour IHC, WB - ABIN3020725
Fan, Zhang, Hu, Li, Zhang: Activation of AKT/ERK confers non-small cell lung cancer cells resistance to vinorelbine. dans International journal of clinical and experimental pathology 2014
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Human Polyclonal MAPK3 Primary Antibody pour IHC (p), IHC - ABIN152967
Nymoen, Hetland Falkenthal, Holth, Ow, Ivshina, Tropé, Kuznetsov, Staff, Davidson: Expression and clinical role of chemoresponse-associated genes in ovarian serous carcinoma. dans Gynecologic oncology 2015
Human Polyclonal MAPK3 Primary Antibody pour IHC (p) - ABIN2473492
: [Aleksandr Semenovich Iontov (on his 70th birthday)]. dans Arkhiv anatomii, gistologii i émbriologii 1978
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Human Monoclonal MAPK3 Primary Antibody pour ICC, FACS - ABIN969277
Karreth, DeNicola, Winter, Tuveson: C-Raf inhibits MAPK activation and transformation by B-Raf(V600E). dans Molecular cell 2009
The present study demonstrated that the downregulation of filaggrin (Montrer FLG Anticorps) in the epidermis by toluene is mediated by ERK1/2 and STAT3 (Montrer STAT3 Anticorps)-dependent pathways.
RASSF7 promotes cell proliferation through activating MEK1 (Montrer MAP2K1 Anticorps)/MEK2 (Montrer MAP2K2 Anticorps)-ERK1/ERK2 (Montrer MAPK1 Anticorps) signaling pathway in hepatocellular carcinoma.
SHP-2 (Montrer PTPN11 Anticorps) may augment the ERK1/2 activity and cell proliferation activity in IL-21 (Montrer IL17C Anticorps) signaling.
intact keratin filaments are regulators for PKB/Akt (Montrer AKT1 Anticorps) and p44 (Montrer GTF2H2 Anticorps)/42 activity, basal and in response to stretch.
Immune profiling of human prostate epithelial cells in health and pathology determined by expression of p38 (Montrer CRK Anticorps)/TRAF-6 (Montrer TRAF6 Anticorps)/ERK (Montrer EPHB2 Anticorps) MAP kinases pathways has been reported.
Integrated ERK1/ERK2 (Montrer MAPK1 Anticorps) response to B (Montrer TDO2 Anticorps)-cell receptor stimulation and SF3B1 (Montrer SF3B2 Anticorps) gene mutations refine prognosis in chronic lymphocytic leukemia.
These findings identified the relationship between ERK1/2 Snitrosylation and phosphorylation.
A cellular threshold for active ERK1/2 levels determines Raf (Montrer RAF1 Anticorps)/MEK (Montrer MAP2K1 Anticorps)/ERK (Montrer EPHB2 Anticorps)-mediated growth arrest versus death responses.
ERK1/2/p53 (Montrer TP53 Anticorps)/PUMA (Montrer BBC3 Anticorps) signaling axis is related to cisplatin-induced cell death in ovarian cancer cells.
results demonstrated that OEA exerts anti-inflammatory effects by enhancing PPARalpha (Montrer PPARA Anticorps) signaling, inhibiting the TLR4 (Montrer TLR4 Anticorps)-mediated NF-kappaB (Montrer NFKB1 Anticorps) signaling pathway, and interfering with the ERK1/2-dependent signaling cascade (TLR4 (Montrer TLR4 Anticorps)/ERK1/2/AP-1 (Montrer FOSB Anticorps)/STAT3 (Montrer STAT3 Anticorps)), which suggests that OEA may be a therapeutic agent for inflammatory diseases.
M-CSF (Montrer CSF1R Anticorps)-evoked ERK1/2 activation was decreased, whereas AKT (Montrer AKT1 Anticorps) activation was enhanced in SHP2 (Montrer PTPN11 Anticorps)-deficient BMMs. ERK1/2, via its downstream target RSK2 (Montrer RPS6KA3 Anticorps), mediates this negative feedback by negatively regulating phosphorylation of M-CSF (Montrer CSF1R Anticorps) receptor at Tyr721 and, consequently, its binding to p85 (Montrer ECM1 Anticorps) subunit of PI3K and PI3K activation.
Low ERK1 Phosphorylation is associated with low liver regeneration.
ERK5 provides a common bypass route in intestinal epithelial cells, which rescues cell proliferation upon abrogation of ERK1/2 signalling, with therapeutic implications in colorectal cancer.
In a retinitis pigmentosa mouse model, TrkC (Montrer NTRK3 Anticorps) activity generates phosphorylated Erk (Montrer EPHB2 Anticorps), which upregulates glial TNF-alpha (Montrer TNF Anticorps), causing selective neuronal death.
A. fumigatus increased PAR-2 expression and elevated disease, PMN infiltration, and proinflammatory cytokine expreERK1 Kinasession through PAR-2, which may be modified by p-ERK1/2.
ERK1 and ERK2 (Montrer MAPK1 Anticorps) play specific roles in beta cells. ERK2 (Montrer MAPK1 Anticorps) cannot always compensate for the lack of ERK1 but the absence of a clear-cut phenotype in Erk1 (-/-) mice shows that ERK1 is dispensable in normal conditions.
The Macrophage Activation Induced by Bacillus thuringiensis Cry1Ac Protoxin Involves ERK1/2 and p38 (Montrer CRK Anticorps) Pathways and the Interaction with Cell-Surface-HSP70 (Montrer HSP70 Anticorps).
hBD-1 potentiates the induction of in vitro osteoclastogenesis by RANKL via enhanced phosphorylation of the p44/42 MAPKs.
ERK1 role in the osteoclast differentiation.Insulin induces RANK expression via ERK1/2, which contributes to the enhancement of osteoclast differentiation.
Suppressing P38 (Montrer CRK Anticorps) promoted adipogenic trans-differentiation and intensified adipolytic metabolism in differentiated cells. However, inhibition of ERK1/2 had the opposite effects on adipogenesis and no effect on adipolysis. Blocking JNK (Montrer MAPK8 Anticorps) weakly blocked trans-differentiation but stimulated adipolysis and induced apoptosis.
MAPK3 role in the oocyte maturation
ERK1/2-Akt1 (Montrer AKT1 Anticorps) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (Montrer SH3GL1 Anticorps) plays an important role in the development of the myeloid cell through activation of the ERK1/ERK2 (Montrer MAPK1 Anticorps) pathway
ERK1 and ERK2 (Montrer MAPK1 Anticorps) target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK1 different specific genes involved in dorsal-ventral patterning and subsequent embryonic cell migration were identified.
These results demonstrate that induction of Hsp70 (Montrer HSPA1A Anticorps) in response to heat stress is dependent on ERK (Montrer MAPK1 Anticorps) activation in Pac2 (Montrer PSMG2 Anticorps) cells.
Data define distinct roles for ERK1 and ERK2 (Montrer MAPK1 Anticorps) in developmental cell migration processes during zebrafish embryogenesis.
MAPK3/1 is involved in luteinizing hormone-mediated decrease of C-type natriuretic peptide and this process is related to the EGFR (Montrer EGFR Anticorps) and MAPK3/1 signal pathways
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Thrombospondin 1 (Montrer THBS1 Anticorps), fibronectin (Montrer FN1 Anticorps), and vitronectin (Montrer VTN Anticorps) are differentially dependent upon RAS, ERK1/2, and p38 (Montrer MAPK14 Anticorps) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (Montrer EGR1 Anticorps) nuclear accumulation.
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
This study demonstrates for the first time that cyclic mechanical stretch induces the proliferation of bovine satellite cells and suppresses their myogenic differentiation through the activation of ERK (Montrer MAPK1 Anticorps).
findings indicate that exposure to DHEA, at concentrations found in human blood, causes vascular endothelial proliferation by a plasma membrane-initiated activity that is Gi/o and ERK1/2 dependent.
Results suggest that estrogen receptors and the ERK1/2 signaling pathway are involved in the anti-apoptotic action of LY117018 in vascular endothelial cells.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Pseudorabies virus glycoprotein gE-mediated ERK 1/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1/2 signaling is associated with degradation of the pro-apoptotic protein Bim (Montrer BCL2L11 Anticorps).
Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
CSF2 (Montrer CSF2 Anticorps) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK (Montrer MAPK1 Anticorps)-dependent MTOR (Montrer FRAP1 Anticorps) signal transduction cascades.
PGRN (Montrer GRN Anticorps) inhibits adipogenesis in porcine preadipocytes partially through ERK (Montrer MAPK1 Anticorps) activation mediated PPARgamma (Montrer PPARG Anticorps) phosphorylation.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (Montrer PRKAA1 Anticorps)/ERK (Montrer MAPK1 Anticorps)/TSC2 (Montrer TSC2 Anticorps)/mTOR (Montrer FRAP1 Anticorps) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (Montrer MAPK8 Anticorps)/2 dependent.
Saccharomyces cerevisiae inhibits the Enterotoxigenic Escherichia coli-induced expression of pro-inflammatory transcripts and this inhibition was associated to a decrease of ERK1/2 and p38 MAPK (Montrer MAPK14 Anticorps) phosphorylation
ERK1 phosphorylation in response to Insulin-like Growth Factor-1 (Montrer IGF1 Anticorps) does not require activation of the Insulin-like Growth Factor-1 receptor tyrosine kinase (Montrer IGF1R Anticorps)
The results suggest that the MPK-1 (Montrer MAPK1 Anticorps)/ERK (Montrer MAPK1 Anticorps) regulatory network, including FBF-1 (Montrer FBF1 Anticorps), FBF-2, and LIP-1 (Montrer CENPJ Anticorps), controls the number of sperm by regulating the timing of the sperm-oocyte switch in C. elegans.
Cek2 (Montrer FGFR3 Anticorps) has a cryptic role in cell-wall biogenesis and its role is not entirely redundant to Cek1.
knockdown of SUV420H1 (Montrer SUV420H1 Anticorps) reduced phosphorylated ERK1 and total ERK1 proteins, and interestingly suppressed ERK1 at the transcriptional level
Secreted aspartic protease-mediated proteolytic cleavage of Msb2 is required for activation of the Cek1 mitogen activated protein kinase (Montrer MAPK1 Anticorps) pathway in response to environmental cues.
The authors propose that a Msb2, Cek1 and Ace2 signalling pathway addresses PMT genes as downstream targets and that different modes of regulation have evolved for PMT1 and PMT2/PMT4 genes.
Msb2 is involved in the transmission of the signal toward Cek1 mediated by the Cdc42 (Montrer CDC42 Anticorps) GTPase (Montrer RACGAP1 Anticorps).
abscisic acid and jasmonate mediate inactivation of the immune-associated MAP kinases (MAPKs), MPK3 and MPK6 (Montrer MAPK6 Anticorps), in Arabidopsis thaliana ABA induced expression of genes encoding the protein phosphatases 2C (PP2Cs), HAI1 (Montrer SPINT1 Anticorps), HAI2 (Montrer SPINT2 Anticorps), and HAI3 through ABF/AREB transcription factors
Constitutive active-MPK3 plants are more resistant to the hemibiotrophic pathogen Pseudomonas syringae DC3000.
constitutively active (CA)-MPK3 crosses with summ1 and summ2, two known suppressors of mpk4 (Montrer MAPK4 Anticorps), resulted in a partial reversion of the CA-MPK3 phenotypes.
that MPK3/MPK6 (Montrer MAPK6 Anticorps) phosphorylate and destabilize ICE1, which negatively regulates CBF (Montrer CEBPZ Anticorps) expression and freezing tolerance in plants
Changes in PUB22 Ubiquitination Modes Triggered by MITOGEN-ACTIVATED PROTEIN KINASE3 Dampen the Immune Response
MPK3 role in ultraviolet induced stomatal closure
Study propose that the pathogen-responsive MPK3/MPK6 (Montrer MAPK6 Anticorps) cascade and ABA are two essential signaling pathways that control, respectively, the organic acid metabolism and ion channels, two main branches of osmotic regulation in guard cells that function interdependently to control stomatal opening/closure.
Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
Data show that the protein kinases MPK3 and MPK6 (Montrer MAPK6 Anticorps) can both interact with SPOROCYTELESS/NOZZLE (SPL (Montrer SGPL1 Anticorps)) in vitro and in vivo and can phosphorylate the SPL (Montrer SGPL1 Anticorps) protein in vitro.
MKK4 (Montrer MAP2K4 Anticorps), MKK5 (Montrer MAP2K5 Anticorps), MKK7 (Montrer MAP2K7 Anticorps), and MKK9, are responsible for the activation of MPK3 and MPK6 (Montrer MAPK6 Anticorps) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (Montrer MAPK1 Anticorps) signaling through MKK4 (Montrer MAP2K4 Anticorps)/5/7/9-MPK3/6 cascades.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
MAP kinase isoform p44
, MAPK 1
, extracellular signal-regulated kinase 1
, extracellular signal-related kinase 1
, insulin-stimulated MAP2 kinase
, microtubule-associated protein 2 kinase
, MAP kinase 3
, p44 MAP kinase
, pp42/MAP kinase
, mitogen-activated protein kinase 3
, MAP kinase 1
, MAPK 3
, mitogen-activated 3
, mitogen-activated protein kinase 1
, extracellular signal-regulated kinase-1
, likely protein kinase